Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Long-acting injectable (LAI) medications represent the combination of a powerful drug substance and an injectable drug formulation that guarantees that the affected tissue is consistently exposed to the active molecule for an extended therapeutic treatment period without elicitin [....] » Read More
Hypertension is a common condition characterized by persistently high blood pressure (140/90 mmHg or higher). Lowering high blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. Regardless of outstanding result [....] » Read More
Most commonly produced and marketed drugs are formulated with the pharmacologically active ingredient in solid form (crystalline or amorphous). The solid form is carefully chosen for its characteristics, to increase the stability of the drug, facilitate its formulation, optimize [....] » Read More
Today’s biomaterials are harming the environment and left unchanged, are predicted to continue to harm the environment in the decades ahead at an alarming rate. Whether through a large carbon footprint during manufacturing, catheter waste, or extensive polymeric cell cultur [....] » Read More
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic mechanism of action (MoA) of paracetamol. A growing body of evidence [....] » Read More
Advances in genetic engineering vaccines have made DNA vaccines a highly promising option for hereditary and acquired illnesses. The main obstacle; nevertheless, is the absence of an ideal delivery system, which severely restricts DNA vaccines' capacity to generate an immune [....] » Read More
Hybrid compounds are artificial scaffolds made of two or more pharmacophores that are jointed or overlapped in a single chemical entity. The strategy of combining two different and independently acting compounds into one covalently linked hybrid compound aims to increase the phar [....] » Read More
Using of nanotechnologies requires detailed analysis of existing obstacles to technology translation. Here we consider some bio nanotechnologies for the treatment of human bones, including its musculoskeletal system, experiencing the maximum load during the functioning of a [....] » Read More
Apillet has developed a unique Oral drug delivery concept (APIVault) which enable targeted release in the intestine of Sensitive (bio)pharmaceuticals, Probiotics and Nutraceuticals. Such compounds are prone to degradation in the stomach and must be protected by a gastro-resistant [....] » Read More
Background: Enrofloxacin (enro) is a broad-spectrum fluoroquinolone antibiotic active against both Gram-positive and Gram-negative bacteria. It is used extensively in both animals and humans due to its high bioavailability and the wide range of susceptible infections. However the [....] » Read More
The formulation of cyclobenzaprine HCl contained in TNX-102 SL has been designed specifically for sublingual administration. Earlier clinical studies indicated that the addition of a basifying agent was necessary for optimal transmucosal absorption. The TNX-102 SL formulation wit [....] » Read More
In a multi-processes pharmaceutical continuous tablet production line such as ConsiGmaTM -25, the quality of the final tablet is a function of different processes and formulation parameters of different units. The effect significance of each unit depends not only on the unit itse [....] » Read More
Pharmaceutical cocrystal is one of the crystal engineering techniques to improve the solubility and bioavailability of active pharmaceutical ingredients (APIs). Cocrystal is a crystal composed of API and other molecules called as coformer. There are many fabrication techniques fo [....] » Read More
Eltrombopag olamine is the active substance of the innovator product Revolade, which is indicated for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and acquired severe aplastic anemia (SAA). The molecule of eltrombopag acquires 6 protonatable sites a [....] » Read More
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic Mechanism of Action (MoA) of paracetamol. A growing body of evidence [....] » Read More
Background: Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Paeoniflorin (PAE) is a monoterpene isolated from Traditional Chinese Medicine (TCM) Paeonia Alba, which has been used as an anti-inflammatory drug in clinical practice wit [....] » Read More
Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site. This paved the way for the development of a smart colonic dr [....] » Read More
Health and social care systems around the globe currently undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions, etc., in personal, soci [....] » Read More
Using a variety of spectroscopic methods and in silico analysis, the binding interactions between three antimalarial medications, mefloquine (MEF), lumefantrine (LUM), and pyrimethamine (PYR) and the primary plasma transporter, human serum albumin (HSA) were examined. Molecular d [....] » Read More
Pharmaceuticals are highly persistent towards hydrolysis, adsorption, biodegradation, and abiotic degradation .As a result, such pharmaceutical compounds are not effectively removed during sewage treatment. Furthermore, sewage effluents and hospital effluents are important point [....] » Read More
Introduction: Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients with advanced fibrosis and poor cardiovascular outcomes. There [....] » Read More
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of highly promising characteristics that we are exploring towar [....] » Read More
Wound dressings play a pivotal role in wound care by cleansing, shielding, and covering wounds, thereby influencing healing duration, cost-effectiveness, and patient comfort. Electrospun fibers emerge as a promising avenue in this field due to their diverse attributes, including [....] » Read More
Acute pancreatitis is a common clinical condition, for which there is no satisfactory treatment available at this time. Excessive systemic inflammatory response syndrome (SIRS) in acute pancreatitis leads to distant organ damage and multiple organ dysfunction syndrome (MODS), whi [....] » Read More
The present investigation is focused on the application of the Quality by Design (QbD) approach for the development and optimization of SLN formulation of Ivacaftor (IVF). IVF SLN was formulated with the help of homogenization and ultrasonication methods by incorporating Labrasol [....] » Read More
Background: The approach to hyponatremia is in a state of flux. Cerebral/renal salt wasting (RSW) is considered rare and presents with identical parameters as SIADH that create a diagnostic and therapeutic dilemma, whether to fluid-restrict water-logged patients with SIADH or adm [....] » Read More
Drug-coated balloon (DCB) treatment has recently emerged as an effective non-stent-based strategy for the treatment of atherosclerotic arteries in peripheral artery disease (PAD). DCBs are designed to dilate into the stenotic lesions while delivering antiproliferative drugs to lo [....] » Read More
The study was conducted to gather information to assess the extent of impact of antimicrobial stewardship (AMSP) practices on antimicrobial prescribing patterns and bacterial resistance profiles among indoor patients across ten ICU and non-ICU departments at the Institute of Post [....] » Read More
The forthcoming presentation will delve into the fundamental tenets of Green Chemistry, highlighting key methodologies such as Phase Transfer Catalysis (PTC), Ionic Liquids (IL), Sonochemistry, and Microwave Irradiation (MWI). These cutting-edge approaches epitomize the evolution [....] » Read More
In vitro drug dissolution is a laboratory test of drug tablets to assess product quality. The test measures drug release (i.e. drug dissolution) from tablets. There are numerous scenarios during drug development, as well in post-market life-cycle management, when there are manufa [....] » Read More
Controlled-release drug delivery systems exhibit a gamut of benefits, including improved therapeutic efficacy, reduced side effects, improved patient compliance, and optimized medicine use. For this reason, there is versatility in drug formulation for controlled release purposes. [....] » Read More
Target/Structure-based drug design needs the presence of the target structure to move forward in the drug discovery process. However, the number of macromolecule structures available in the available data banks is limited relative to the high macromolecule sequence release. Homol [....] » Read More
Background: Mesenchymal Stromal Cells (MSCs), a multipotent stem cell population which can efficiently be obtained from different tissue sources, exert key specific regenerative and immunomodulatory properties. However, MSCs require priming through binding of IFN-γ to the r [....] » Read More
The present study aimed to formulate rivaroxaban nanosuspension by nanoprecipitation with the ultrasonication method and was stabilized by different concentrations of Fenugreek Seed Mucilage, Microcrystalline Cellulose and Carboxymethyl Cellulose. The formulated nanosuspensions w [....] » Read More
Introdution: 1, 3, 4-oxadiazole is a five membered heterocyclic aromatic compound containing two nitrogen atom at position three and four and one oxygen atom present at position one. 1, 3, 4 oxadiazole is thermally stable than other oxadiazoles, these oxadiazole are very&nbs [....] » Read More
In recent years, various types of natural polymers have gained prominence in drug delivery systems due to their biocompatibility, biodegradability, and ease of modification. Recent research has further enhanced the capabilities of these polymers, expanding their functions in drug [....] » Read More
Among the fungal genera, members of the genus Candida are most common causal organisms of human infections. In recent years, increasing drug resistance in fungal pathogenic strains specifically, clinical strains require immediate attention to develop alternative antifungal agents [....] » Read More
Infectious diseases especially associated with multidrug resistant pathogens in critically ill patients is an area of global research and concern for healthcare professionals across both private and public sector. Sulbactam and Durlobactam have been approved as a combination drug [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Human Papillomavirus (HPV) vaccines are vaccines used for vaccination against human papillomavirus infection. HPV vaccines prevent infection from different types of human papillomavirus which cause risk for cervical cancer. Vaccination with different types of HPV has an impact [....] » Read More
Despite the widespread use of hypodermic needles in intradermal medication delivery, they remain a source of pain and trauma in patients young and old. The research introduces a novel approach to active medication delivery using microneedle arrays, utilizing the high swellability [....] » Read More
Pregnant women are exposed to a variety of environmental pollutants – pesticides, drugs, substances of abuse or cosmetic raw materials that enter the body of a mother-to-be by a variety of routes - oral (with contaminated food or water), through skin or mucous membranes or [....] » Read More
The calculated specifications of Roll Porous Scaffold (RPS) are orders of magnitude superior to all currently dominant 3D bioprinters in speed, volume, and print density without the use of expensive equipment and components: print density of 10−15 µm cells u [....] » Read More
MDR-bacteria causes sepsis and death in patients due to their power to inactivate antibiotics like ampicillin, cefotaxime, tetracycline, streptomycin, chloramphenicol, erythromycin and ciprofloxacin. The mdr genes (amp, blaCTX-M, blaNDM1, cat, aac2’/3’/6’, strAB [....] » Read More
Introduction: Preeclampsia(PE) is pregnancy related syndrome which is mainly by gestational hypertension with proteinuria. it affects 2 to 10 % of pregnant women. Improper maternal spiral artery remodelling leads to decreased perfusion to the placenta. Hypoxic placental orga [....] » Read More
To develop and validate a simple and sensitive UV spectrophotometric method for Quantification of Hesperidin in bulk and Ayurveda formulation including plant extracts using chromogenic compound Gibb’s reagent (2, 6-Dichloro quinone 4-Chloroimide). Chromogenic method was dev [....] » Read More
Background: Lawsonia inermis L. (Lawsone) was reported to contain carbohydrates, proteins, flavonoids and phenolic compounds, alkaloids, terpenoids. The plant has also been reported to have hepatoprotective, anti-inflammatory, antiviral, antifungal and anticancer properties. Laws [....] » Read More
Psoriasis, an incurable chronic inflammatory skin disease, is characterised by enhanced angiogenesis, abnormal keratinocyte differentiation, and immune cell invasion. Angiogenesis, a critical factor in endothelial cell proliferation, adhesion, and migration, is driven by the ov [....] » Read More
Medicinal plants have been fundamental in both traditional and modern medicine, offering a wide array of bioactive compounds crucial for therapeutic purposes. The escalating impact of climate change presents notable risks to the accessibility and effectiveness of these essential [....] » Read More
Extracts from plant sources have been mined for their anti-cancer potential. The n-butanolic extract of the leaves of A.muricata exhibited a higher cytotoxic potential in MDA-MB-435s & HaCaT cells in comparison with normal hepatic cells. The free radical scavenging potential [....] » Read More
Pharmaceuticals are essential to ensure the high standards of human health and wellbeing. Extensive and uncontrolled usage under different classes such as antibiotics, analgesics, antipyretics, antidepressant, anticonvulsants, beta-blockers, and steroids, etc. pose high environme [....] » Read More
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D spending in 2026 are Roche, Johnson & Johnson, Merck [....] » Read More
Cancer remains a global health threat despite advances in research and technology. According to International Agency for Research on Cancer, the cancer burden will increase by about 77% by 2050, further straining health systems, people and communities. Although cancer chemotherap [....] » Read More
Surface and physico-chemical properties are critical in formulation and in processes involving the handling, processing, packaging, shelf-life and bioavailability of medicines. In this presentation, we will explore and discuss the intricate ways in which interactions at the surfa [....] » Read More
The overprescription of pharmaceuticals, a phenomenon known as medicationalization, has led to unintended environmental consequences, contributing to the rising issue of pharmacopollution. This article explores the intricate relationship between medicationalization and pharmacopo [....] » Read More
Membrane proteins constitute 30% of the genome in organisms and are involved in numerous physiological processes. ABC transporters is a class of membrane proteins which are ubiquitously present in all organisms, bind and hydrolyze ATP to power the solute transport and are associa [....] » Read More
An electro magneto elastic actuator is electro magneto mechanical device intended for actuation of mechanisms, systems based on the piezoelectric, electrostriction, piezomagnetic, magnetostriction effects, converts electric or magnetic signals into mechanical movement and force. [....] » Read More
Objective: The surge in incidents of acute poisoning from pharmaceuticals and chemicals necessitates the exploration of effective and safe treatment alternatives. This review aims to evaluate the efficacy, underlying mechanisms, and safety profiles of plant-based detoxifying agen [....] » Read More
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Title : Personalized and precision medicine (PPM) as a unique healthcare model to be set up via biodesign, bio- and chemical engineering, translational applications, and upgraded business modeling to secure the human healthcare and biosafety
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Pharmacokinetic properties of TNX-102 SL, a sublingual formulation of cyclobenzaprine hydrochloride
Bruce Daugherty, Tonix Pharmaceuticals, United States
TNX-102 SL is a sublingual formulation for cyclobenzaprine (CBP) hydrochloride (HCl) designed for bedtime dosing that is being developed for fibromyalgia (FM) via improvement in sleep quality. TNX-102 SL is a eutectic formulation of CBP and D-mannitol (see companion abstracts, Fo [....] » Read More
Title : Mannitol as eutectic forming agent for improved sublingual delivery of Cyclobenzaprine HCl
Marino Nebuloni, University of Insubria, Italy
In solid drug product formulation, the knowledge of possible interactions between the drug substance and the excipients is a crucial point for the prediction of chemical and physical stability. Often, an excipient(s) can modify the biological activity and chemical stability of th [....] » Read More
Title : Clinical decision making in advanced and metastatic breast cancer cases between PARP inhibitors and CDK4/6 inhibitors
Priya Hays, Hays Documentation Specialists, LLC, United States
Background: PARP inhibitors and CDK 4/6 inhibitors have been studied extensively as model targeted agents for advanced and metastatic breast cancer with hormone receptor positive/HER2 negative molecular subtype, the most common in the patient population. Both agents have been eva [....] » Read More
Title : Gastrointestinal performance simulation system for the analysis of eltrombopag formulations
Stella Kafkala, Genepharm Pharmaceutical Company, Greece
Eltrombopag olamine is the active substance of the innovator product Revolade, which is indicated for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and acquired severe aplastic anemia (SAA). The molecule of eltrombopag acquires 6 protonatable site [....] » Read More
Title : Microemulsion based in situ gel of Erythromycin for Ocular Ailments
Dasharath Muljibhai Patel, Gujarat Technological University, India
Background: Conventional preparation of erythromycin ointment is available in the market as an ocular formulation. Ointment dosage form is linked to many side effects, including transient blurred vision, irritation and redness of the eye. Ointment dosage form also shows very low [....] » Read More
Title : Preparation and characterization of inhaled luteolin nano-liposomes for the potential management of pulmonary arterial hypertension
Fatma Haddad, University of Bradford, United Kingdom
Luteolin is a natural flavonoid abundant in several fruits, vegetables, and medicinal herbs. Although luteolin has numerous pharmacological activities, its low water solubility and bioavailability restrict its therapeutic efficacy. This work aims to overcome these limitations by [....] » Read More
Title : Supercritical microfluidic system for production of nanoparticles and liposomes for pharmaceutical formulation
Yusuke Shimoyama, Tokyo Institute of Technology, Japan
Pharmaceutical formulation techniques have been developed as achieving controlled-release system and high bioavailability of active pharmaceutical ingredients (APIs). Formation of the pharmaceutical suspension with nanoparticles or liposomes is one of the dosage forms to increase [....] » Read More
Title : The promise of nanotechnology in personalized & precision medicine: Drug discovery & development being partnered with nanotechnologies via the revolution at the nanoscale
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
A new systems approach to subclinical, predictive and/or diseased states and wellness resulted in a new Hi Tech trend in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, despite breakthroughs in designed-driven research that have led to an i [....] » Read More
Title : Development and evaluation of prolonged-release dutasteride transdermal delivery system
Shereen M Assaf, Jordan University of Science and Technology, Jordan
Benign prostatic hyperplasia (BPH), an enlargement of the prostate affecting older men, leads to urinary complications. Oral administration of Dutasteride (DTS) is a common treatment, but it poses challenges for the elderly, including difficulty in taking the medication by mouth, [....] » Read More
Title : Potential bruton tyrosine kinase (BTK) inhibitors determined by virtual screening, molecular docking, and molecular dynamics simulation studies
Alper Onder, Canakkale Onsekiz Mart University, Turkey
Bruton tyrosine kinase (BTK) is a downstream mediator of the B cell receptor (BCR) signalling pathway and affects B cell proliferation and differentiation. Evidence showing BTK expression in the majority of hematological cells has led to the hypothesis that BTK inhibitors such as [....] » Read More
Title : In silico, synthesis, and in vitro studies of novel FOXM1 Inhibitors for targeted triple negative breast cancer therapy
Ferah Comert Onder, Canakkale Onsekiz Mart University, Turkey
Triple-negative breast cancer (TNBC) is subtype of breast cancer is known for aggressive, leading to early relapses, metastasis and poor clinical prognosis. Significant heterogeneity and drug resistant phenotype and lack of effective targeted therapeutics contribute to poor patie [....] » Read More
Title : Design and assessment of transdermal delivery system containing Levodopa-Loaded Nanoparticles
Shereen M Assaf, Jordan University of Science and Technology, Jordan
Levodopa, an essential precursor of dopamine, was widely used to address motor disorders in the early stages of Parkinson's disease. However, its effectiveness was hindered by a short plasma half-life, enzymatic conversion in the systemic circulation, limited absorption in th [....] » Read More