Title : Drug design for the development of long-acting injectables
Abstract:
Long-acting injectable (LAI) medications represent the combination of a powerful drug substance and an injectable drug formulation that guarantees that the affected tissue is consistently exposed to the active molecule for an extended therapeutic treatment period without eliciting unwanted side effects. Many marketed LAI drugs owe their success to a formulation principle that is perfectly tailored to the drug substance, yet to date there is no comprehensive overview of how drug molecules can be designed in a smart way to facilitate and accelerate technical formulation development at a later stage. This presentation will summarize the key properties of low-molecular weight drugs that are predestined for different LAI formulations and suggest design principles as well as operational flow chart elements to streamline preclinical research and development (R&D) at the interface of chemical and pharmaceutical sciences.
Audience Take Away Notes:
- Design principles of injectable drug products for patient compliance and safety
- Properties of injectable vs. oral drug substances
- Guidance for the discovery and optimization of long-acting injectables (LAI)
- Practical aspects of LAI research (flow charts and assays)
- Importance of early collaboration between Research and Development
