Objective: The utilization of herbal medicines has risen globally. Recently, the possible adverse effects of certain herbs have been observed, particularly concerning hepatotoxicity associated with the consumption of herbal treatments. This review aims to assess the evidence [....] » Read More
The present talk will discuss experimental data regarding successful fabrication of a novel Cu2+-complex of nitrogen-rich polymer nanodots, with a mean diameter of about 20 nm extracted from transmission electron microscopy (TEM) micrographs and 350 nm obtained from dynamic light [....] » Read More
The Medicines Discovery Catapult (MDC) is a UK-based national life sciences service, headquartered in Alderley Park, supporting innovators across the full drug discovery and early development pathway through R&D consultancy, Discovery Laboratories and National Programmes. Our [....] » Read More
Oral mucoadhesive drug delivery systems, particularly buccal films, have gained increasing attention as promising alternatives to conventional dosage forms. These flexible systems adhere to the oral mucosa for extended periods without causing discomfort, thereby enhancing the abs [....] » Read More
Introduction: Pulmonary surfactants in liposomes production became relevant components due to their compatibility with the pulmonary environment. However, the understanding of critical process parameters (CPP) needs to be elucidated. Thus, Quality by Design (QbD) combined with a [....] » Read More
Although effective in removing stains from teeth, peroxides can trigger severe side effects, such as gum inflammation and dental hypersensitivity, due to free radical penetration into dentinal tubules. In this scenario, Sarcomphalus joazeiro stands out as a promising alternative; [....] » Read More
This investigation aimed to formulate and comprehensively evaluate matrix-type transdermal drug delivery systems incorporating Methotrexate (MTX) for sustained therapeutic release in Rheumatoid Arthritis management and chemotherapeutic regimens. MTX-loaded transdermal patches wer [....] » Read More
Alkaline-earth-metal functionalization (Mg²+ and Ca²+) enhances the drug loading capacity and photothermal performance of black phosphorene (BP) for cancer theranostics. Density Functional Theory and TD-DFT analyses show that metal coordination significantly strengthens [....] » Read More
Background: Oral insulin delivery remains a long-standing challenge due to enzymatic degradation and poor intestinal permeability. Glucose-responsive smart polymeric nanocarriers represent an emerging strategy to enable self-regulated insulin release while improving bioavail [....] » Read More
Psoriasis is a chronic inflammatory skin disorder that requires effective and well-tolerated anti-inflammatory therapies. A dendrimer-based system with promising immunomodulatory properties has been explored; however, its clinical potential remains limited by insufficient skin pe [....] » Read More
Glioblastoma (GBM) is an aggressive and highly invasive brain tumor characterized by poor prognosis and limited therapeutic success due to the presence of the blood–brain barrier (BBB) and intrinsic treatment resistance. Conventional treatment strategies, including surgery, [....] » Read More
Background: Arteether (ART) is a potent antimalarial drug, but its clinical utility is limited due to low aqueous solubility and poor oral bioavailability. This study aimed to develop an ART-loaded nanoemulsion (ART-NE) to improve systemic exposure and antimalarial efficacy [....] » Read More
Heavy metal-free quaternary semiconductor nanoparticles have recently emerged as a promising agent for biomedical applications owing to their tunable optical properties, enhanced biocompatibility and reduced toxicity. In this study, Cu–In–Zn–S (CIZS) nanoparticl [....] » Read More
Neisseria gonorrhoeae AniA and its homologs in other Gram-negative bacteria are significant targets due to their roles in electron transport, anaerobic survival, and pathogenic persistence, rendering them significant for anti-virulence strategies. The conserved structural charact [....] » Read More
Background: Kaolin is made up of the clay mineral kaolinite, soft white or yellowish lumps, insoluble in water. Kaolin contains 47% silica, 40% alumina, and 13% water. Its adsorption properties allow it to act as a drying and antidiarrheal agent. This study aims to determine the [....] » Read More
Internationally, more than 70 million people’s diagnosed with chronic hepatitis C virus. Treatment of Hepatitis C is done by administration of direct-acting antiviral, Entecavir. Entecavir exhibits poor aqueous solubility, which significantly limits its clinical appli [....] » Read More
Advanced drug delivery systems are designed to address key limitations of conventional formulations, particularly poor solubility, limited bioavailability, and lack of controlled release. γ-Cyclodextrin-based metal organic frameworks (γ-CD-MOFs) have recently emerged [....] » Read More
Papaver species are recognized as valuable sources of biologically active alkaloids with diverse pharmacological properties. However, the phytochemical composition and biological activities of Papaver umbonatum Boiss. remain largely unexplored. The present study investigated the [....] » Read More
Introduction: Anticancer drugs exert harmful side effects on healthy tissues of the body. Cardiac adverse effects are mainly associated with certain agents, particularly anthracyclines. Clinical Observation: A 44-year-old woman with a history of right breast carcinom [....] » Read More
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of highly promising characteristics that we are exploring towar [....] » Read More
For realizing pervasive and ubiquitous health and social care services, health and social care system have to undergo an organizational, methodological and technological transformation towards personalized, participative, preventive, predictive precision medicine. For designing a [....] » Read More
Sepsis is a major health problem worldwide. It is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-related deaths represent 19·7% of deaths from all causes worldwide. Outcomes for patients suffering from sepsis are p [....] » Read More
Silk fibroin (SF) and chitosan (CS) are promising biopolymers for biodegradable scaffolds in regenerative therapies. Here, we produced SF/CS composite plugs at 70:30 and 60:40 ratios and compared them to single-polymer controls to examine their physicochemical traits and prelimin [....] » Read More
Binding of drugs to plasma proteins plays a critical role in determining pharmacokinetics, bioavailability, and therapeutic efficacy. Among plasma proteins, Human Serum Albumin is the primary carrier responsible for transporting a wide range of endogenous compounds and pharm [....] » Read More
Solar ultraviolet (UV) radiation is a major environmental toxicant that contributes to inflammation, immunosuppression, and carcinogenesis. Previous studies suggest that UVB-induced oxidative stress generates oxidized lipids with platelet-activating factor (PAF) agonistic activit [....] » Read More
Lipid nanoparticles (LNPs) have gained traction in recent years due to their use in the COVID-19 vaccine. They are able to deliver nucleic acids, enabling cells to transiently acquire novel therapeutic functions. Yet, one persistent problem remains: the inability to achieve cell- [....] » Read More
Polydopamine (PDA) has attracted significant interest as a multifunctional material for advanced drug delivery systems due to its bioinspired catechol amine chemistry, excellent biocompatibility, and strong surface adhesion. The rich chemical functionality of PDA enables versatil [....] » Read More
Intranasal drug administration has gained considerable attention as a non-invasive approach for delivering therapeutic agents directly to the central nervous system (CNS). This route provides the potential to bypass the blood–brain barrier and improve drug targeting to the [....] » Read More
Cannabinoids are the primary active compounds in Cannabis sativa, which has been used for over 4000 years as a recreational drug. The main psychoactive constituent of hemp is Δ9-tetrahydrocannabinol (Δ9-THC). In plants, it occurs as the non-psychoactive tetrahydrocann [....] » Read More
Colorectal cancer (CRC) progression is critically driven by its hydrogen sulfide (H?S)-rich tumor microenvironment, which paradoxically confers chemoresistance by stabilizing redox homeostasis while promoting immune evasion. To transform this vulnerability into a therapeuti [....] » Read More
Hypertension is a lifestyle disorder. Mostly the disorder is asymptomatic until it gets diagnosed. Hypertension for a longer duration if gets uncontrolled can cause the problems to the eye, kidney blood vessels, and other organs. It may cause heart attack, kidney failure, or [....] » Read More
Hypertension is a major chronic cardiovascular disorder requiring prolonged pharmacotherapy and consistent maintenance of therapeutic plasma concentrations to achieve optimal clinical outcomes. Conventional immediate-release antihypertensive formulations often result in fluctuati [....] » Read More
Formulating plasma proteins as liquid dosage forms is challenging due to limited excipients and risks of physical and chemical instability, including aggregation and loss of efficacy. Strategies such as DoE, QbD, and rational design approaches, combined with stabilizers, buffers, [....] » Read More
Pharmaceuticals are essential for maintaining human health and have become an indispensable part of modern life. However, their widespread and often uncontrolled use has led to growing concerns about environmental contamination and potential risks to human health. In recent years [....] » Read More
The synchronization of drug delivery with the body’s circadian rhythm has emerged as a transformative approach in pharmaceutical drug development. Conventional dosage forms largely ignore biological time-dependent variations, often leading to sub-optimal therapeutic outcome [....] » Read More
A series of novel 3-spiro-2-oxindoline derivatives incorporating an aromatic hydrazide linker were rationally designed and synthesized as potential VEGFR-2 inhibitors. This work specifically aimed to evaluate the influence of linker rigidity on biological activity, in comparison [....] » Read More
Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue. This study aims to discover novel antibiotic alternatives by using the whole [....] » Read More
Drug Development or exploration of new lead compounds is always remain a fundamental field in health sciences. Other than engineering side which is generally for human comfort and convenience, the biological sciences is very crucial due to its direct involvement in human health. [....] » Read More
Background: Sudan is among the richest African countries in plant diversity, hosting thousands of flowering species used for centuries in traditional medicine to treat a wide range of ailments. Despite this extensive biodiversity and deep ethnopharmacological heritage, the pharma [....] » Read More
Developing age appropriate dosage forms is critical for effective pharmaceutical therapy, particularly chronic conditions like paediatric tuberculosis (TB) requiring prolonged treatment. The world health organization recommends the use of Fixed dose combination (FDCs) of first li [....] » Read More
Artificial Intelligence (AI) has emerged as a transformative tool in drug discovery, significantly reducing the time, cost, and complexity associated with traditional pharmaceutical research. From a pharmacy perspective, AI applications span multiple stages of drug development, i [....] » Read More
Oxazolone derivatives have gained significant attention due to their wide spectrum of biological activities, particularly anticancer potential. Breast cancer remains a leading cause of mortality among women, highlighting the need for novel therapeutic agents. In this study, 36 de [....] » Read More
This study presents a machine learning approach to classify diabetes status using the CDC BRFSS 2015 dataset, which includes over 250,000 self-reported health records across 22 variables. The goal was to develop a multi-class classification model to identify individuals as No, Ye [....] » Read More
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder in the world. While it primarily hinders motor functions, PD also causes cognitive dysfunctions which can progress to severe conditions like dementia. Despite the significant impacts of cognitive [....] » Read More
The blood-brain barrier (BBB) is a highly selective and protective interface that regulates the transport of substances between the bloodstream and the central nervous system (CNS). Astrocytes, a major component of the neurovascular unit, play a critical role in maintaining BBB i [....] » Read More
The recent developments in the pharmaceutical field have shown major drawbacks regarding the traditional drug delivery system such as the lack of bioavailability, non-specific distribution, and dose-related systemic toxicity. Stimuli-responsive smart drug delivery systems (SDDS) [....] » Read More
The problem of microplastic pollution has become one of the most significant and significant environmental and toxicological issues, and the evidence of its occurrence in human tissues increases. Recent observations of microplastics in human testicular tissue have brought about s [....] » Read More
Title : From marker to mechanism: Ligand discovery enables functional analysis of OR51E1, an ectopic olfactory receptor, in prostate cancer
Vladlen Slepak, University of Miami, United States
OR51E1 is a G protein-coupled receptor that belongs to the family of olfactory receptors, but is found in a few tissues outside the nasal epithelium. It widely reported as a prostate cancer–associated marker, yet its functional role has remained unclear due to the lac [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model based on design-inspired biotech- & biopharma-driven applications to secure the human healthcare and biosafety
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Despite breakthroughs in research that have led to an increased understanding of PPM-based human disease, the translation of discoveries into therapies for patients has not kept pace with medical need. Modern drugs are crucial in the field of PPM-guided drug therapy and are curre [....] » Read More
Title : Biocompatible synthesis of non crystalline iron oxide nanoparticles with stable colloidal properties
Lan Wang, Paretor LLC, United States
Biocompatible iron oxide nanoparticles (IONPs) are widely used in targeted and responsive delivery, yet conventional formulations adopt crystalline spinel phases that generate magnetic interactions and aggregation, constraining spaciousness and colloidal stability. To overcome th [....] » Read More
Title : A NAMs-compatible mechanopharmacological model of drug penetration in the urinary bladder
Kunal Sharma, University of Bern, Switzerland
Conventional antibiotic efficacy metrics fail to capture the mechanopharmacology of bladder infections, where pathogens persist within protected intracellular and subepithelial reservoirs that drive chronic disease. The bladder uroepithelium is a stratified, mechanosensitive barr [....] » Read More
Title : Antibody proteases as translational tools of the next step generation to be applied for biopharmacy related and precision medical practice
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
High impact of Ab-proteases is valuable to monitor both clinical and subclinical courses of chronic autoimmune inflammation to predict stepwise transformations of the course, starting from the pre-illness and to prognosticate the clinical illness finally. This infor-mation would [....] » Read More
Title : Nebulized mesenchymal stem cell-derived exosomes encapsulating interferon-α2b: A synergistic strategy for targeted treatment of severe viral
Liu Yan, Ruijin Hospital, China
Background: Severe viral pneumonias, particularly those caused by influenza A virus, respiratory syncytial virus (RSV), and emerging coronaviruses, continue to pose formidable challenges to global public health. While Interferon-alpha (IFN-α) remains a cornerstone of antivi [....] » Read More
Title : Notch-targeted tumor microenvironment-responsive drug delivery for efficient treatment of metastatic colorectal cancer by remodeling its signal dynamics
Dake Chu, Xian Jiaotong University, China
The incidence of colorectal cancer has been rising steadily, with the Notch signaling pathway playing a crucial oncogenic role in its pathogenesis. Targeted modulation of this pathway represents a promising therapeutic strategy. However, current Notch pathway inhibitors frequentl [....] » Read More
Title : Co-delivery of antiviral and anti-inflammatory agents via dry powder inhalation for viral pneumonia
Chang Ren, School of Pharmacy, Henan University, China
Viral pneumonia remains a significant global health challenge, with current therapeutic approaches often limited by inadequate drug delivery to the primary infection site and the need to address both viral replication and excessive inflammation simultaneously. We present an innov [....] » Read More
Title : Fabrication of anti-EGFR-grafted lipid nanoparticles for effective delivery of anti-cancer drug: A multifaceted approach combating breast cancer
Charu Misra, Suresh Gyan Vihar University, India
Background: Cabazitaxel, US-FDA synthetic taxane has been highly recognized in treatment of metastatic prostate cancer. Clinical evidences show the drug also exhibit potency in treatment of breast cancer. Despite numerous advantages this drug undergoes various challenges like low [....] » Read More
Title : Non-crystalline stabilization of iron-oxide nanoparticles enables a versatile platform for carrier-dependent and carrier-free drug delivery
Lan Wang, Paretor LLC, United States
We investigated alternative routes for tuning nanoparticle drug-delivery behavior by deliberately disrupting spinel lattice formation during iron-oxide: magnesium synthesis. Under constrained, automation-compatible co-precipitation conditions, defective ferrite assembly prevented [....] » Read More
Title : Azobenzene-enriched PEG-PLGA micelles as a light-responsive drug delivery platform: Effect of light on biological activity
Mila Radan, University of Split, Croatia (Hrvatska)
Azobenzene derivatives have the potential to enable light-induced modulation of biological activity. In this study, azobenzene-enriched PEG-PLGA micelles were developed as a delivery system for a selected anticancer agent, with the aim of improving its delivery properties and ena [....] » Read More
Title : Electrospun mucoadhesive nanofiber platform incorporating functionalized gold nanorods for nose to brain drug delivery
Ignacia Paz Torres Fredes, Univeristy of Chile, Chile
The development of effective strategies for central nervous system (CNS) drug delivery remains a major challenge due to the presence of the blood brain barrier and the limited bioavailability of many therapeutic compounds. Intranasal administration has emerged as a promising non [....] » Read More
Title : Self-assembled DNA-collagen bioactive scaffolds for enhanced cellular uptake and neuronal differentiation
Nihal Singh, Indian Institute of Technology Gandhinagar, India
Different modalities of DNA-Collagen complexes have been utilized primarily for gene delivery studies. However, very few studies have investigated the potential of these complexes as bioactive scaffolds. Further, no studies have characterized the DNA-Collagen complex formed from [....] » Read More
Title : Ultrasound responsive bioactive microbubbles for enhanced drug delivery
Niyati Shah, Indian Institute of Technology Gandhinagar, India
In recent years, enzyme powered micro/nanomotors have emerged as ideal platforms for realizing various biological applications due to their multifunctionality and specificity in operation under complex conditions. However, most motors developed so far suffer from issues pertainin [....] » Read More
Title : Ligand-directed and pH-responsive liposomal systems for advanced pulmonary drug delivery
Abhinav Mehta, R C Patel Institute of Pharmaceutical Education and Research, India
Pulmonary drug delivery has emerged as an attractive approach for achieving localized and systemic therapeutic effects while minimizing systemic exposure. The present study focuses on the development of a multifunctional liposomal delivery platform integrating ligand-mediated tar [....] » Read More
Title : Easily injectable, organic solvent free self assembled hydrogel platform for endoscope mediated gastrointestinal polypectomy
Hitasha Vithalani, IIT Gandhinagar, India
Endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are widely employed for removing small, flat gastrointestinal (GI) lesions, but their success depends on creating a durable submucosal cushion. Conventional injectables such as saline and hypertonic dex [....] » Read More
Title : Overcoming the PEG dilemma via tris-Based surface engineering for acidic microenvironment-responsive tumor-specific uptake and Intracellular delivery
Susumu Hama, Musashino University, Japan
Background: The clinical success of cancer nanomedicines depends on their ability to overcome the “PEG dilemma.” While modification with polyethylene glycol (PEG) is the gold standard for achieving prolonged systemic circulation and enhanced tumor accumulation via the [....] » Read More
Title : Road to relief: Managing varicose vein in labour and professional drivers
Prasanta Bera, KLE College of Pharmacy, India
Background: Varicose veins (VV) are prevalent among labour workers and drivers due to prolonged standing or sitting, leading to increased venous pressure. Objective: This study aims to investigate the correlation between occupational factors and the incidence of varicose veins [....] » Read More
Title : Pharmacovigilance in Algeria: Current status, challenges and future perspectives
Benhaddou A I, University of Djillali Liabes Sidi Bel Abbes, Algeria
Background: Pharmacovigilance plays a fundamental role in ensuring drug safety by detecting, assessing, understanding, and preventing adverse drug reactions (ADRs). In Algeria, pharmacovigilance has progressively evolved within the healthcare system, particularly following t [....] » Read More