A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insu [....]
Toxic substances and secretions of animals such as snakes, spiders and scorpions have been used in traditional medicine for the treatment of several diseases. Despite of the inherent difficulty and high economic risk in [....]
Hypothesis: The transurethral prostatectomy syndrome (TURS) is defined as severe vascular hypotension reaction that complicates endoscopic surgery as a result of massive irrigating fluid absorption causing severe acute d [....]
Famotidine is an antacid drug given orally in management of benign gastric and duodenal ulceration, It is very slightly water soluble. The aim of work is to study the effect of hydrotropic agents (trisodium citrate dihyd [....]
Diabetes Mellitus (DM) is a severe chronic disease affecting a large population worldwide. Africa is rich in native medicinal plants with myriad health benefits, though less explored towards the development of specific d [....]
Transferrin receptors (TfRs) are overexpressed in tumor cells but are scarce in normal tissues, which makes TfR an attractive target for drug treatment of cancer. The objective of this study was to evaluate the potential [....]
Nitrile derivatives are known to cause toxicities like neurotoxicity, hepatotoxicity, cardiovascular, renal and gastrointestinal disorders. Nitriles collates a broad range of chemicals including Acetonitrile, Acrylonitri [....]
Design and development of biodegradable water-based poly (urethane-urea) dispersions, with poly(ε-caprolactone)–D-glucose polyester polyol as a central core for combining properties of end-functionalized st [....]
Shellac is a unique natural resin derived from the secretion of insects, widely used as an enteric coating in the pharmaceutical industry. Despite the high potential of shellac as a protective coating and in controlled e [....]
Background: Gas chromatography – mass spectrometry and high performance liquid chromatography are commonly used methods for determination of benzodiazepines. GC-MS is a specific method and is used for its sensitive [....]
Naturally isolated compounds have broad range of varieties in their structures than the synthetic ones. A large number of drugs approved by FDA (Food and Drug Administration) have derived from plants are natural co [....]
Crystallization of pharmaceutical ingredients, primarily those that possess several polymorphic forms, particle size and morphology critical properties, are among the most serious and least understood manufacturing proce [....]
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular pa [....]
The aim of this study is focused on the reproduction of a routinely used individual preparation, its physicochemical, accelerated and real-time stability testing to predict the rate of change at a proposed storage temper [....]
Pyrethroids are the synthetic insecticides, widely used in household, agricultural field etc to kill pests and insects. Their extensive and unrestricted usage leads to human exposure to these toxic chemicals. These compo [....]
The objective of this study was to evaluate preventive effects of Olea europaea L. leaves aqueous extract on subacute intoxication by lead acetate. Three groups of male rabbits were formed: a negative control, a group in [....]
In pharmaceutical research the transdermal route of drug has gain great interest, transdermal delivery has enhanced a novel vasicular drug carrier system called transferosome which composed of water, surfactant and phosp [....]
Diabetes is severe chronic metabolic disease characterized by high blood glucose levels leads to generation of reactive oxygen species that causes oxidative damage in kidney, liver and pancreas.The aim and purpose of pre [....]
This study was devoted to the learning changes in the structure of erythrocyte membranes at the level of molecular bonds during their storage at a positive temperature by means method of infrared spectroscopy (IR). Objec [....]
Drug Delivery to Stem Cells in Regenerative Medicine
Esmaiel Jabbari, University of South Carolina, USA
Translation of nanoscale discoveries from the laboratory to the clinic promises new diagnostic tools, drug targeting modalities, gene therapy platforms, and tissue constructs for patients. Tissue morphogenesis during fet [....]
Targeted nanoparticles for diagnostic and theranostic applications
Paul Millner, University of Leeds, UK
Targeted nanoparticles provide an exciting opportunity for delivery of drugs to specific tissue locations but also for imaging and sensing applications. Many drugs, and in particular chemotherapy agents, are too toxic to [....]
Nanostructured Formulations in Skin Cancer: Challenges and Perspectives
Daniela Monti, University of Pisa, Italy
The incidence of skin cancer, the most common malignant disease that mainly affects the Caucasian population, is increasing worldwide. There are three main types of skin cancers: basal cell carcinoma (BCC), squamous cel [....]
Introducing the Sorush Cancer Treatment Protocol (SCTP)
Sorush Niknamian, Violet Cancer Institute, USA
This research introduces Sorush Cancer Treatment Ptotocol (SCTP) based on successful cancer treatment methodology which has done by Dr. Somayeh Zaminpira and Dr. Sorush Niknamian in 54 cancer patients in Violet Cancer In [....]
Hydrogen Sulfide: A Stinky Gas….. and Novel Therapeutic Target for Inflammatory Disease
Madhav Bhatia, University of Otago, Newzealand
To be Updated Soon..
Assessment an umbilical cells induced neuroplasticity in patients with schizophrenia using functional MRI
Dmitry Ustyuzhanin, National Medical Research Center of Cardiology, Russia
Purpose. To evaluate changes in the brain activation patterns using fMRI in patients with schizophrenia underwent an umbilical cells injections. Materials and Methods. 15 patients (males, aged 20-40 years) with schizo [....]
Evaluation of drug permeability in blood-brain barrier in vitro models
Anna Caprifico, Kingston University, UK
Treatment of disorders of the central nervous system such as malignant brain tumours is hindered by the blood-brain barrier (BBB), whose role is to protect the brain from undesirable microorganisms, substances or drugs c [....]
Bryophyllum pinnatum Compounds Inhibit the Oxytocin-Induced Pathways in Human Myometrial Cells
Stefanie Santos, University Hospital Zurich, Switzerland
Bryophyllum pinnatum is a succulent perennial plant traditionally used in the treatment of premature labour, first in anthroposophic hospitals and, recently, in conventional settings as an add-on medication. Experimental [....]
Cancer: is there any hope?
Ranjita Shegokar, Capnomed GmbH, Germany
Cancer is a complex disease. Several drug delivery platforms are under development in academia and in industry to deliver therapeutic molecules and new chemical entities to the targeted site in body. Amongst them, nanote [....]
Process innovation in the production of smart lipid-polymeric release systems
Annalisa Dalmoro, University of Salerno, Italy
Liposomes are the most versatile carriers for the delivery of a large variety of both lipophilic and hydrophilic drug molecules, being biocompatible and biodegradable. Despite their great advantages, their tendency to de [....]
In vitro anticancer screening of crude plant polar extracts
Janice Mani, Central Queensland University, Australia
Numerous commercial pharmaceuticals – including anticancer, antiviral, and antidiabetic drugs have been developed from traditional plant-derived medicines. With approximately 25,000 species of flora occurring in Au [....]
Degradation-free intracellular delivery of nanomolar protein cargoes with a ganglioside GM1 specific recognition tag
Tamas A. Martinek, University of Szeged, Hungary
There is a pressing need to develop ways to deliver therapeutic macromolecules to their intracellular targets. Lipid raft-mediated/caveolar endocytosis is exploited by viruses (simian virus 40, murine polyoma virus and e [....]