The solid-state characterization of pharmaceutical compounds plays a pivotal role in understanding and controlling the physical and chemical properties of active pharmaceutical ingredients (APIs) and excipients. This work presents an integrated overview of analytical techniques a [....] » Read More
Understanding drug transport in plasma is pivotal to optimizing therapeutic outcomes, as it governs drug distribution, efficacy, and clearance. A key factor in this process is protein binding, where drugs reversibly interact with plasma proteins such as albumin and alpha-1-acid g [....] » Read More
This research explores the creation of a novel exosome delivery platform, termed Exo-ITC, tailored for use in dermatology. Exosomes, as extracellular vesicles, are pivotal in intercellular communication and exhibit substantial therapeutic potential in regenerative medicine and de [....] » Read More
In this keynote talk, the traditional disc diffusion-test bioassay is revisited within the perspective of using a mathematical approach grounded on the standard as well as on the modified Hill model. Importantly, the Hill model was established in 1910 to account for the binding o [....] » Read More
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Introduction: Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients with advanced fibrosis and poor cardiovascular outcomes. [....] » Read More
Psychedelic drugs acting upon the serotonergic receptors are currently considered to be not only substances of abuse, but also the hope of new therapies of mental problems such as depression, PTSD and eating disorders; pain; inflammations or even asthma. The main challenge in thi [....] » Read More
The morphology of nanosystems is one of the Critical Quality Attributes (CQAs) of the nanoformulations, affecting the interactions of cellular membranes as well as the release of the encapsulated active substances. Hybrid systems are mixed systems composed of different in-nature [....] » Read More
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D spending in 2026 are Roche, Johnson & Johnson, Merck & [....] » Read More
The advantages of 3D bioprinting, tissue engineering and regenerative medicine represent a powerful potential for everyone who wants to always be healthy, young or rejuvenate. Overcome the shortage of organs for implantation and personal hormone replacement therapy for everyone w [....] » Read More
Dibutyl phthalate and nonylphenol from endocring disruptors were removed photocatalycally with nanocomposites derivated from printed circuit board wastes. These wastes represent 3% of the total mass of waste electric and electronic equipment and have revealed the following compos [....] » Read More
In the realm of cerebrovascular incidents, the safeguarding of cerebral vasculature is recognized as a paramount goal. This talk will focus on the recent advances made in the domain of nanoparticle mediated drug delivery systems for cerebrovascular disorders. Worldwide in our eff [....] » Read More
This study investigated the therapeutic potential of phlorizin for Alzheimer's disease (AD) using an integrated computational and experimental pharmacology approach. The research aimed to determine how phlorizin modulates key AD biomarkers, including AChE, Bcl-2, caspase-3, a [....] » Read More
Antibiotic resistance is a global problem. The incidence and prevalence of antimicrobial-resistant-bacterial infections has attained incongruous levels during 21st century and threatens global public health as a silent pandemic, necessitating urgent interventions. Enzybiotics are [....] » Read More
Pharmaceuticals have undoubtedly lengthened life spans, cured millions from deadly diseases, and made life comfortable and free from pain. This very success has now led to their emergence as rapidly growing environmental pollutants and contaminants. Acetaminophen (4’-hudrox [....] » Read More
One of the primary challenges in pharmaceutical dosage form development is the poor solubility of certain drugs, particularly those classified as Biopharmaceutics Classification System (BCS) Class IV. These drugs exhibit low solubility and permeability, resulting in suboptimal ph [....] » Read More
Biopolymers play critical roles in structure, function, storage, and regulation of biological processes in living beings. Bacterial biopolymers, such as alginate, lipopolysaccharides (LPS), polyhydroxyalkanoates (PHAs), and exopolysaccharides (EPS), play a crucial role in the pat [....] » Read More
Mineral and metallic nanomedicines are a precious resource found in the Ayurvedic medical system. Rasashastra is an Ayurvedic branch that deals with the preparation and therapeutic use of nanomedicines. A weak interdisciplinary collaboration between science and Ayurveda ultimatel [....] » Read More
The increase in life expectancy has led to a rise in age-related disorders, including neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Oxidative stress (OS) plays a crucial role in the pr [....] » Read More
Syzygium balsameum Wight is shrubs or trees of the Myrtaceae family. The present study reports on the based-onand isolation of a flavonoid 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalconefrom the leaves of Syzygium balsameum and evaluation of the antioxidant [....] » Read More
The escalating demand for pharmaceuticals derived from natural sources has catalyzed extensive research aimed at optimizing the synthesis of secondary metabolites in plants. Secondary metabolites, including alkaloids, flavonoids, terpenoids, and phenolics, are crucial to contempo [....] » Read More
While multiple therapeutic options exist for melanoma, their overall responses in the majority of patients remain relatively low due to the interference of counter-regulatory mechanisms. This indicates the need to understand the underlying mechanisms and devise alternative approa [....] » Read More
Silver nitrate (AgNO3) nanoparticles have gained significant attention for their antimicrobial and anticancer properties. This study presents a green, sustainable, and cost-effective method for synthesizing AgNO3 nanoparticles via a honey-mediated technique, where the natural sug [....] » Read More
A large number of organic solvents (chloroform, hexane, methanol, dimethyl formamide, ethanol, benzene, toluene, carbon tetrachloride, methylene chloride, acetonitrile etc) are employed in various types of pharmaceutical analysis viz. HPLC, TLC, HPTLC, UV spectrophotometry, Titri [....] » Read More
This study presents a machine learning approach to classify diabetes status using the CDC BRFSS 2015 dataset, which includes over 250,000 self-reported health records across 22 variables. The goal was to develop a multi-class classification model to identify individuals as No, Ye [....] » Read More
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. However, the drug has the unintentional side effects of erectile dysfunction and infertility. The impact on [....] » Read More
For realizing pervasive and ubiquitous health and social care services, health and social care system have to undergo an organizational, methodological and technological transformation towards personalized, participative, preventive, predictive precision medicine. For designing a [....] » Read More
Hydrogen sulfide is a toxic gas, which is an environmental and industrial pollutant. In recent years, however, it has been shown that this gas is also synthesized in the body, and acts as a potent vasodilator. Substance P is an 11 amino acid neuropeptide from the tachykinin famil [....] » Read More
Prescribed drug abuse denotes the potential misuse of pharmacological formulations. Many regulatory agencies are working to improve rules for current and future drug formulations by using some level of abuse deterrent technologies. Opioids are often and widely misused substances [....] » Read More
Globally, Oral Squamous Cell Cancer(OSCC) is a significant public health burden in terms of health care costs as well as lost man-hours and school-hours. This form of neoplasia ranks 3rd both in terms of the number of cancers as well as in terms of the mortality data. Further, it [....] » Read More
The bioavailability crisis remains a major bottleneck in drug development, particularly for hydrophobic compounds such as paclitaxel and medroxyprogesterone acetate (MPA). Paclitaxel, a first-line chemotherapeutic, is extremely water-insoluble and is currently marketed mainly as [....] » Read More
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of highly promising characteristics that we are exploring towar [....] » Read More
Precision oncology plays an essential role for the treatment of solid cancers. Colorectal cancer has emerged as a disease condition where abnormal genetic mutations occur in a group of colorectal cancer patients. Patients with advanced colorectal cancers are often associated with [....] » Read More
Infected and chronic wounds represent a significant healthcare challenge due to their complex healing processes and the presence of persistent microbial biofilms that interfere with tissue repair. Conventional antimicrobial agents often present limitations, such as poor water sol [....] » Read More
Medication errors are a leading cause of preventable harm in healthcare systems worldwide, with significant implications for patient safety and therapeutic outcomes. Within the European Union (EU), addressing medication errors has become a key priority to enhance public health an [....] » Read More
The objective of this study was to assess the suitability of novel mucoadhesive hydrogel platforms for delivering therapeutics targeting gastrointestinal (GI) disorders. To this end, we developed and characterized novel hydrogels based on self-assembling lipopeptides namely MPD02 [....] » Read More
Adiponectin, a major cytokine from adipose tissue and hsCRP, a well established marker of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD), when levels fluctuate from the normal levels in the blood. Aims and objective: The aim of ou [....] » Read More
Penetration of immune cells into the brain, activation of glia and secretion of inflammatory mediators like cytokines and free radicals like nitric oxide (NO) play key role in Multiple sclerosis (MS); an autoimmune disease. Phytocannabinoidshave anti-inflammatory properties [....] » Read More
Over two decades, a large number of nucleosides have been synthesized, which demonstrated potent antiviral and antitumour activities and have become cornerstones of treatment for patients with cancer or viral infections. Oligonucleotide-based antisense strategies represent a uniq [....] » Read More
Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the DNA sequence, has revolutionized our understanding of complex biological processes and disease mechanisms. In drug development, epigenetics offers promising avenues for identifyi [....] » Read More
Drug delivery systems as a technological system formulate and store drug molecules into suitable forms of medications. Effective process development plays a key role in mitigating risk, accelerating time-to-market, and significantly reducing development costs for pharmaceutical c [....] » Read More
Ayurveda is science of the life. Maintenance of the health of healthy individuals and Treatment of the diseased are the main principles of Ayurveda management. Acharya Sushruta, The Father of Surgery, explained different types of surgeries and documented procedures in a sophistic [....] » Read More
Cancer remains a global health threat despite advances in research and technology. According to International Agency for Research on Cancer, the cancer burden will increase by about 77% by 2050, further straining health systems, people and communities. Although cancer chemotherap [....] » Read More
Pharmacopollution is a public health and environmental outcome of some active pharmaceutical ingredients(API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are the pharmaceutical industry, healthcare facilities (e.g., hos [....] » Read More
Personalized medicine has emerged as a transformative approach in healthcare, focusing on optimizing therapeutic outcomes by tailoring drug delivery systems to individual patient needs. Traditional drug administration methods often exhibit limitations such as systemic toxicity, p [....] » Read More
A comprehensive bioanalytical method was developed and validated for the simultaneous estimation of Linagliptin and Empagliflozin in fixed-dose combination formulations using UV spectrophotometry. This study emphasizes three distinct analytical approaches—Simultaneous Equat [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
The presence of genotoxic impurities like nitrosamine in pharmaceutical products has become a pressing global safety concern due to their potential carcinogenic and mutagenic e8ects. NAs, particularly N-nitroso compounds, are classified as probable human carcinogens, raising the [....] » Read More
In systemic inhalation delivery, the respiratory tract is used as a route of administration, allowing the active ingredient to enter the blood circulation directly through the alveoli. It is not for lung diseases, but for the treatment of other diseases of the body. As a po [....] » Read More
Title : Ectopically expressed olfactory receptors as an untapped family of drug targets and discovery of agonists and antagonists of OR51E1, an understudied G protein-coupled receptor
Vladlen Slepak, University of Miami Miller School of Medicine, United States
Over 30% of pharmaceuticals act on G protein-coupled receptors (GPCRs), the largest family of human genes (~800). About 50% of GPCRs (~400) are Olfactory receptors (ORs); these GPCRs were originally discovered in the nasal epithelium, where they mediate the sense of smell. [....] » Read More
Title : Innovative development and delivery of biologics for chronic obstructive pulmonary disease
Yong Xiao Wang, Albany Medical College, United States
It is well known that chronic obstructive pulmonary disease (COPD) is a common and devastating lung disease with a high mortality. The current therapeutics for this disease are neither specific nor very effective. Moreover, the pathogenesis mechanisms for this disease remain larg [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through de-sign-inspired biotech- & biopharma-driven applications and upgraded business mar-keting to secure the human healthcare and biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Traditionally, a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Macitentan/tadalafil combination– An additional value in pharmacotherapy of pulmonary arterial hypertension
Miroslav Radenkovic, University of Belgrade, Serbia
Pulmonary arterial hypertension (PAH) remains a devastating disease with high morbidity and mortality. It is uncommon, progressive and life-threatening blood vessel disorder differentiated by the constriction of minor pulmonary arteries and elevated blood pressure in the pulmonar [....] » Read More
Title : Identification of sulfonamide-based aromatase inhibitors in the breast cancer research
Barbara De Filippis, University of Chieti, Italy
Breast cancer (BC) represents the type of cancer that most frequently affects women and one of the leading causes of death among females worldwide. Approximately 70% of cases of BC are estrogen dependent (Hormone Receptor-Positive, HR+), since high levels of these hormones are ne [....] » Read More
Title : Pharmacology of chlorphenamine and pseudoephedrine use in the common cold
Rassa Pegahi, UPSA, France
The common cold is the most frequent upper respiratory viral infection. Although benign, it represents a high socioeconomic burden. Many over-the-counter drugs are available to manage the symptoms of this condition, with antihistamines and vasoconstrictors being the most widely u [....] » Read More
Title : Antibody-proteases as translational tools of the next-step generation to be applied for biopharmacy-related and precision medical practice
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
High impact of Ab-proteases is valuable to monitor both clinical and subclinical courses of chronic autoimmune inflammation to predict stepwise transformations of the course, starting from the pre-illness and to prognosticate the clinical illness finally. This information would a [....] » Read More
Title : Is paracetamol (acetaminophen) still a first line option for pain and fever in paediatrics?
Rassa Pegahi, UPSA, France
Background and Aim: Effective analgesia and fever management in children from birth remain crucial. This study aims to provide updated insights into the use of paracetamol in pediatric care. Methods: A comprehensive bibliographic search was conducted, focusing on clinical stud [....] » Read More
Title : Innovations in rivastigmine delivery: Nanostructured lipid carriers encapsulated in microneedles for enhanced transdermal delivery
Shereen M Assaf, Jordan University of Science and Technology, Jordan
Rivastigmine (RHT), used in the management of Alzheimer's disease, reduces acetylcholine degradation and enhances the cognitive function. Challenges in RHT delivery arise due to its limited ability to permeate the brain, short half-life, low bioavailability, and abdominal sid [....] » Read More
Title : Assessment of inulin content in Arctium Lappa l. root extract: Potential for nutritional and medicinal applications
Elena Donici, State University of Medicine and Pharmacy, Moldova, Republic of
Inulin, scientifically known as α-D-glucopyranosyl-β-D-fructofuranosyl-D-fructofuranoside, is a natural polysaccharide with diverse biological activities. It is widely used in the food and pharmaceutical industries as a soluble dietary fiber, sugar substitute, stabiliz [....] » Read More
Title : Evaluating Aronia Melanocarpa varieties for pharmaceutical applications based on polyphenolic content and antioxidant activity
Iulia Bozbei, State University of Medicine and Pharmacy, Moldova, Republic of
In recent years, the global community has been actively seeking plant-based sources with therapeutic and nutritional potential. The fruits of Aronia melanocarpa are widely recognized and utilized for these purposes. The challenges caused by global warming and changing climatic co [....] » Read More
Title : Therapeutic efficacy of nanostructured lipid carriers co-loaded with simvastatin and adenosine (NLC- SA) in a human epidermal model of diabetic chronic wound
Regina Gomes Dare, University of São Paulo, Brazil
Chronic wounds are characterized by persistent inflammation, elevated oxidative stress, and impaired tissue repair, posing a major clinical challenge, particularly in diabetic patients. In this study, we established a reconstructed human epidermis (RhE) model using primary neon [....] » Read More
Title : Advances in hydrophilic drug delivery: Encapsulation of biotin in alginate microparticles
Iria Naveira Souto, Reig Jofre | University of Barcelona, Spain
The encapsulation of hydrophilic drugs within microparticles has gained significant interest in drug delivery systems due to their potential to improve the stability, bioavailability, and controlled release of therapeutic agents. Biotin, a water-soluble vitamin, faces challenges [....] » Read More
Title : Formulation and characterization of buccal films based on sodium alginate and chitosan for using in parkinson's disease
Krisztian Pamlenyi, University of Szeged, Hungary
Parkinson's disease is the second most common neurodegenerative disease in the world, 16-20 thousand people suffer from this disease in Hungary and more than 10 million people worldwide. The symptoms can be various, both non-motor and motor symptoms can appear. The biggest pr [....] » Read More
Title : The promise of nanotechnology in personalized & precision medicine: Drug discovery & development being partnered with nanotechnologies via the revolution at the nanoscale
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
A new systems approach to subclinical, predictive and/or diseased states and wellness resulted in a new Hi Tech trend in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, despite breakthroughs in designed-driven research that have led to an in [....] » Read More
Title : GastroPlus® and ADMET Predictor driven predictive model for pharmacokinetic parameters of ENDOL® immediate-release capsule
Ayse Nur Oktay, University of Health Sciences-Gulhane Faculty of Pharmacy, Turkey
In silico tools have become indispensable for preclinical assessment of pharmacokinetic parameters of drug. Several commercial software platforms, such as GastroPlus®, PK-Sim®, Stella®, and GISim®, offer comprehensive simulation capabilities for drug absorption, [....] » Read More
Title : Design and computational analysis of a peptide analogue with a WXXW motif: A membrane-active and reversible drug binding peptide to overcome cancer drug resistance
Nurul Ain binti Mohammad Hamdi, University of Manchester, United Kingdom
Membrane-active peptides are known for their ability to transport therapeutic agents across cellular membranes, thereby enhancing intracellular delivery. In this study, we designed a membrane-active peptide analogue by incorporating a drug-binding sequence. This modification aims [....] » Read More
Title : Enhancing delivery of biopharmaceutics classification system class ii drugs through a novel carrageenan-alginate-oleogel matrix: A case study on praziquantel for improved therapeutic efficacy
Consolata Nsanzubuhoro, Stellenbosch University, South Africa
Schistosomiasis, a waterborne neglected tropical disease (NTD) prevalent in sub-Saharan Africa and South-East Asia significantly impacts socio-economic development. Praziquantel (PZQ) serves as the primary treatment, effective against all human schistosome species. However, PZQ&# [....] » Read More
Title : What Caffein brings to Paracetamol (Acetaminophen) in pain Management
Rassa Pegahi, UPSA, France
Background: Paracetamol is effective and safe in mild to moderate migraine attacks and episodes of tension-type headache (TTH). Few data are available on the use of paracetamol combined with caffeine, the aim of which is to achieve a higher analgesic efficacy of paracetamol [....] » Read More
Title : Enabling Active Pharmaceutical Ingredient Industry in Saudi Arabia
Waleed Mohammed Al Shaqha, Imam Muhammed Ibn, Saudi Arabia
The local production of active pharmaceutical ingredients (APIs) plays a vital role in strengthening national healthcare resilience by improving access to essential medicines and reducing dependence on imports and global supply chains. While the API industry is heavily driven by [....] » Read More
Title : Intelligent delivery of 5-fluorouracil using smart polymers
Mutaz S Salem, Jordan University of Science and Technology, Jordan
Colonic drug delivery systems have been utilized to treat a wide range of bowel illnesses, including colorectal cancer, ulcerative colitis, diverticulitis, Crohn's disease, and IBS. These systems can improve therapeutic efficacy by limiting undesired absorption in other parts [....] » Read More
Title : Astrotactin 2 as novel analgesic target candidate for cancer pain and opioid sparing: An exploratory genetic polymorphism analysis
Mizuho Sumitani, The University of Tokyo Hospital, Japan
Introduction: Cancer pain impairs not only physical functions but also social functions and roles. Neuronal protein astrotactin 2 (ASTN2) fulfills a function to regulate the release of neuronal adhesions to the glial fiber. Genetic variability in the ASTN2 gene was reportedly ass [....] » Read More
Title : Evaluating maleic anhydride derivatives as linkers for Ph-sensitive drug release
Mateusz Mlynek, NanoSanguis S.A., Poland
Cancer remains a persistent global health challenge. Current therapeutic strategies often fall short due to the adaptive nature of tumor cells, highlighting the urgent need for innovative drug delivery approaches. Recent advances emphasize improved drug selectivity through platfo [....] » Read More
Title : Evaluating maleic anhydride derivatives as linkers for Ph-sensitive drug release
Weronika Leszczynska , NanoSanguis S.A., Poland
Cancer remains a persistent global health challenge. Current therapeutic strategies often fall short due to the adaptive nature of tumor cells, highlighting the urgent need for innovative drug delivery approaches. Recent advances emphasize improved drug selectivity through platfo [....] » Read More
Title : Evaluating Maleic Anhydride Derivatives as Linkers for Ph-Sensitive Drug Release
Julia Macyszyn, NanoSanguis S.A., Poland
Cancer remains a persistent global health challenge. Current therapeutic strategies often fall short due to the adaptive nature of tumor cells, highlighting the urgent need for innovative drug delivery approaches. Recent advances emphasize improved drug selectivity through platfo [....] » Read More
Title : Liposomal formulation and quantitative HPLC analysis of random peptide mixtures for antibacterial drug development
Michal Szkop, NanoSanguis S.A., Poland
The rising antibiotic resistance among bacterial pathogens presents a growing global health concern, necessitating the exploration of novel therapeutic approaches. One promising alternative to traditional antibiotics is the use of peptides. Random peptide mixtures (RPMs), charact [....] » Read More
Title : Liposomal formulation and quantitative HPLC analysis of random peptide mixtures for antibacterial drug development
Marzena Kaliszewska Kozak , NanoSanguis S.A., Poland
The rising antibiotic resistance among bacterial pathogens presents a growing global health concern, necessitating the exploration of novel therapeutic approaches. One promising alternative to traditional antibiotics is the use of peptides. Random peptide mixtures (RPMs), charact [....] » Read More
Title : The Physicochemical, biopharmaceutical, and in vitro efficacy properties of diclofenac-loaded liposomes
Iria Naveira Souto, Reig Jofre | University of Barcelona, Spain
Diclofenac-loaded liposomes were developed as a tool to treat inflammatory skin disorders. Topical administration of this molecule is a challenge that can be addressed by encapsulation into drug delivery systems. The aim of the current study was to develop, purify and optimize th [....] » Read More