Title : An innovative gastric floating microsponge system for controlled drug release.
Abstract:
Joint inflammation caused by arthritis is characterized by warmth, discomfort, tenderness, and swelling. A high concentration of inflammatory cells, including granulocytes, macrophages, and lymphocytes, will irritate the joints during inflammation. As a result, the synovium will enlarge, and the bones and joints will get damaged. Nonsteroidal anti-inflammatory medicines (NSAIDs) can be used to relieve the pain and inflammation associated with arthritis. Indomethacin is a very strong, non-selective COX inhibitor that inhibits B- and T-cell proliferation and neutrophil migration. One of the most popular medications for treating gouty arthritis is indomethacin, which is used instead of colchicine. The suggested dosage of indomethacin as an anti-inflammatory is 50–70 mg three times a day, with a half-life of around 4-5 hours. It is poorly soluble in water and, as a weak acid, is well absorbed in the upper gastrointestinal tract. A patient with rheumatoid arthritis (RA) may benefit from indomethacin's ability to quickly enter and spread throughout the synovial fluid. Additionally, there is a new indomethacin formulation that uses the Quasi Emulsion Diffusion Method to create a colon-targeted pulsing cap drug delivery system. To the best of my knowledge, no research has been published on the use of an innovative gastroretentive microsponge to treat gouty arthritis. One of the most recent matrix gastroretentive systems is the microsponge system, which is made up of spherical microparticulate structures made of interconnecting channels that combine to provide a large porous surface and a rigid, long-lasting structure. These microparticulate structures feature pores smaller than 0.25 μm and a diameter of 5–300 μm. Compared to other gastroretentive systems, microsponge systems have shown superior advantages, such as reduced dose dumping, self-sterilization, high entrapment efficiency (50–60%), sustained and controlled release, enhanced drug thermal, chemical, and physical stability, free-flowing characteristics, and compatibility with a variety of ingredients. In addition to pharmacological benefits, this approach has economic advantages. The microsponge system is thought to be more affordable than other systems, such as liposomes and nanocapsules. The goal of my research is to create a gastric floating microsponge dosage form for indomethacin that will improve its solubility, stability, and formulation flexibility while lowering its toxicity and extending its anti-arthritic effects.
