Chemo-enzymatic Synthesis of bridged nucleosides

Title : Chemo-enzymatic Synthesis of bridged nucleosides

Abstract:

Over two decades, a large number of nucleosides have been synthesized, which demonstrated potent antiviral and antitumour activities and have become cornerstones of treatment for patients with cancer or viral infections. Oligonucleotide-based antisense strategies represent a unique paradigm for the treatment of a wide variety of human diseases. In order to discover new class of nucleoside derivatives with enhanced biological activities, the modifications in the sugar moietiy have been attempted, which provide a remarkable level of control over nucleoside sugar puckering and its biological activity. Herein, we report; (a) the selective biocatalytic acetylation studies on modified 3′-azido-4′-C-hydroxymethylated sugar derivatives with an aim to develop an efficient and easy method for the synthesis of ribo-azido/amino LNA monomers and xylo-azido/amino spiro-oxetano nucleosides and (b) the selective biocatalytic deacetylation studies on modified 3′-azido-4′-C-acetoxymethylated sugar derivatives with an aim to develop an efficient and easy method for the synthesis of ribo-azido/amino spiro-oxetano nucleosides and xylo-azido/amino LNA monomers.

Biography:

Dr. Rajesh Kumar received his Master of Science degree in organic chemistry from the University of Delhi in 2010. He joined the same department for a PhD and completed his Ph.D. in 2017 and during his Ph.D., Dr. Kumar visited the University of Southern Denmark as a Research Assistant for nine months.  After completion of Ph., he joined as Assistant Professor in Chemistry at B.R.A. Bihar University, India. He has published 25 research papers in reputed national and international journals such as The Journal of Organic Chemistry, Theranostics, Carbohydrate Research, RSC Advances, etc. His research interest lies in Nucleic acid chemistry, Biotransformations, Catalysis, Green Chemistry, and heterocyclic chemistry.