Title : Biodegradable ribbon for Roll Porous Scaffold 3D bioprinting technology
Abstract:
The advantages of 3D bioprinting, tissue engineering and regenerative medicine represent a powerful potential for everyone who wants to always be healthy, young or rejuvenate. Overcome the shortage of organs for implantation and personal hormone replacement therapy for everyone with the help of printed endocrine glands. Accelerate targeted therapy, personalized medicine with simultaneous testing of many methods and drugs of treatment, determining the most effective with minimal toxicity. 3D biomodels "organ on a chip" allow to replace parallel testing of new substances on animals. It is logical that the key to rejuvenation is not in nutrition and climate, because if a grandmother, even from the Forbes list, lives with her granddaughter in the "Blue Zones" (the Mediterranean or Okinawa), eats the same fresh food, drinks the same water from the purest mineral springs, then the first will continue to age, and the second will flourish. Hormone replacement therapy has long proven that the best way to restore youth is to restore hormone levels. No hormonal gels, pills, injections, etc. can compare with your own young endocrine glands, created for each person, based on his DNA and will prevent rejection. However, the current progress of bioprinting is not enough to create complex organs. These objects require precise multicellular systems with vascular integration, which is currently impossible with traditional bioprinting methods. Modern development of technologies does not allow the production of microvessels, but only macrovessels with limited mechanical integrity. Bioprinting of small capillaries is now a difficult task, since modern patented methods can make organoids and vessels Ø> 100 μm at a speed of ~ 1 cm3/hour. The support material of the bioink must retain its shape after printing in order to obtain sufficient dimensional integrity and mechanical strength. Accordingly, the new 3D bioprinting technology, which surpasses all currently dominant indirect analogs, is very relevant. Roll Porous Scaffold is proposed to quickly and effectively overcome the listed difficulties without using too expensive laser-polymer gels and launching printers into space. During the implementation of the 1st stage of the grant "Fund for Assistance to Innovations" the following results were achieved.
- The composition of the film material based on biocompatible high-molecular compounds was developed.
- Film samples for laser perforation were manufactured.
- Optimal parameters of laser perforation specifications were selected.
For the first time, dozens of multi-colored water-soluble films with the possibility of laser burning were created, films with a thickness of ~50−60 μm were made, perforated with cells of 30−160 μm. A laboratory sample of a tape porous composite material of the following dimensions was manufactured: 100×100×(0.02−0.1) mm, 0.1−0.7 g.
