Title : Eco-friendly hydrotropic technology in pharmaceutical analysis precluding the use of hazardous organic solvents
Abstract:
A large number of organic solvents (chloroform, hexane, methanol, dimethyl formamide, ethanol, benzene, toluene, carbon tetrachloride, methylene chloride, acetonitrile etc) are employed in various types of pharmaceutical analysis viz. HPLC, TLC, HPTLC, UV spectrophotometry, Titrimetry etc. Organic solvents are volatile. The vapours of organic solvents are inhaled by the persons involved in such analysis. Several ill effects caused by vapours of these organic solvents include neurological disorders, liver damage, renal failure, mutagenesis disorder, bad effects on vision etc. In the present lecture, it shall be clear that solubilizing properties of safe and economic solids shall be used to carryout such analysis. Aqueous solutions of safe and economic solids shall replace harmful organic solvents. Aqueous solutions of hydrotropic agents like sodium benzoate, sodium citrate, niacinamide, urea, sodium acetate, sodium salicylate etc shall be used as solvent systems to carryout such analysis without the employment of organic solvents. Mixed hydrotropic solutions are also used in place of organic solvents in pharmaceutical analysis. Hydrotropic and mixed hydrotropic solutions are cheap and harmless.
