Abstract:
In this keynote talk, the traditional disc diffusion-test bioassay is revisited within the perspective of using a mathematical approach grounded on the standard as well as on the modified Hill model. Importantly, the Hill model was established in 1910 to account for the binding of oxygen molecules to hemoglobin and since then has been used as a standard model for evaluation of a wide plethora of experimental situations, including cell viability assays. As for the challenging material, Cu-doped tin oxide (SnO2) spherical nanoparticles (mean size 8.3 nm) will be tested against two bacteria cultures, namely the Gram positive Staphylococcus aureus (S. aureus) and the Gram negative Escherichia coli (E. coli). Although limited in terms of variety of challenging materials and bacteria cultures, the success of the proposed mathematical approach while explaining the experimental data is quite impressive. The outcomes of the present analysis point quite favorably toward the general use of it in the very near future. New concepts, such as the biological size and the biological size dispersity, for instance, will emerge naturally from the data analysis reported in the talk.
Biography:
Paulo C. DE MORAIS (H-60), PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013, Appointed as UnB’s Emeritus Professor (2014), Appointed as Guest Professor of Huazhong University of Science and Technology – China (2011), Visiting Professor at Huazhong University of Science and Technology (HUST) – China (2012-2015), Appointed as Distinguished Professor at Anhui University (AHU) – China (2016-2019), Appointed as Full Professor at Catholic University of Brasília (UCB) – Brazil (2018), Appointed as CNPq-1A Research Fellowship since 2010. 2007 Master Research Prize from UnB, 2008-member of the European ERA NET Nanoscience Committee, Member of the IEEE-Magnetic Society Technical Committee, Senior Member of the IEEE Society, 2012 China’s 1000 Foreign Expert Recipient, and 2012 Academic Excellence Award from Brazilian Professor’s Union. He held two-years (1987-1988) post-doc position with Bell Communications Research – New Jersey, USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais – Brazil. He graduated in both Chemistry (1976) and Physics (1977) at UnB. Professor Morais is member of the Brazilian Physical Society and the Institute of Electrical and Electronics Engineers – IEEE. He has served as referee for more than 50 technical journals, takes part of the Editorial Board of more than 15 technical journals and has conducted research on nanomaterials for over 40 years. He has delivered about 190 Invited Talks all over the World. He is known for his research in preparation, characterization and applications of nanosized materials (magnetic fluid, magnetoliposome, magnetic nanoemulsion, magnetic nanocapsule, magnetic nanofilm, magnetic nanocomposite, nanosized semiconductors, polymeric dots, carbon dots, and graphene quantum dots). With more than 500 published papers in peer reviewed journals, more than 13,000 citations, more than 200 international invited talks, and more than 15 filed patents, He has appeared in recent World ranking of top scientists, such as 2020-Stanford, 2022-Research.com, 2023-AD Scientific Index, 2023-Research.com, 2024-Elsevier, and 2025-AD Scientific Index.
