Mathematical modeling the disc diffusion test: Antibacterial activity of copper-doped SnO2

Title : Mathematical modeling the disc diffusion test: Antibacterial activity of copper-doped SnO2

Abstract:

In this keynote talk, the traditional disc diffusion-test bioassay is revisited within the perspective of using a mathematical approach grounded on the standard as well as on the modified Hill model. Importantly, the Hill model was established in 1910 to account for the binding of oxygen molecules to hemoglobin and since then has been used as a standard model for evaluation of a wide plethora of experimental situations, including cell viability assays. As for the challenging material, Cu-doped tin oxide (SnO₂) spherical nanoparticles (mean size 8.3 nm) will be tested against two bacteria cultures, namely the Gram positive Staphylococcus aureus (S. aureus) and the Gram negative Escherichia coli (E. coli). Although limited in terms of variety of challenging materials and bacteria cultures, the success of the proposed mathematical approach while explaining the experimental data is quite impressive. The outcomes of the present analysis point quite favorably toward the general use of it in the very near future. New concepts, such as the biological size and the biological size dispersity, for instance, will emerge naturally from the data analysis reported in the talk.

Biography:

Professor Paulo César De Morais (H61), PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013. Appointed as UnB’s Emeritus Professor (2014); Visiting Professor at the Huazhong University of Science and Technology (HUST) – China (2012-2015); Distinguished Professor at the Anhui University (AHU) – China (2016-2019); Full Professor at the Catholic University of Brasília (UCB) – Brazil (2018); CNPq-1A Research Fellow since 2010; 2007 Master Research Prize from UnB. He held two-years (1987-1988) post-doc position with Bell Communications Research, New Jersey – USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais (UFMG) – Brazil. With more than 14,000 citations, He has presented more than 250 invited talks (35 countries), published more than 500 papers (Web of Science) and filed 16 patents.