Study of serum adiponectin and hsCRP in diabetic patients

Title : Study of serum adiponectin and hsCRP in diabetic patients

Abstract:

Adiponectin, a major cytokine from adipose tissue and hsCRP, a well established marker of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD), when levels fluctuate from the normal levels in the blood.

Aims and objective: The aim of our study was to evaluate the levels of these parameters and determine their correlation with glycemia in order to assess the cardiovascular risks in the patients with type 2 diabetes mellitus

Materials and methods: The study was conducted in the department of Biochemistry, Santosh Medical college, Ghaziabad with 25 type 2 diabetic patients and 25 age and sex matched controls. Ethical clearance from the institution and informed consent from the patients were taken prior the study. Adiponectin was analysed by ELISA and blood sugar and CRP were estimated by kit based method.

Results: Fasting blood sugar (FBS, 158.2±37.2) and hsCRP (3.97±1.54) were significantly high,  adiponectin was significantly low in the patients with diabetes compared to controls (80.52±9.72, 1.27±0.75 and 10.78±1.69 respectively, p<0.05). Adiponectin showed negative correlation with FBS (r=-0.427) and hsCRP (r=-0.336) but the correlation was significant only in case of FBS (p<0.05). hsCRP positively correlated with FBS (r=0.568) and was statistically significant.

Conclusion: The results of our study further support the role of adiponectin and hsCRP as predictive biomarker of CVD risks in the patients suffering from type 2 diabetes.

Biography:

Motivating and talented Biochemistry Professor, driven to inspire students to pursue academic and personal excellence. Exceptional track record of research success with multiple published articles. Dr. Preeti Sharma is currently working at Autonomous State Medical College, Fatehpur, UP, India, deeply involved in teaching and research. Her area of research has been interdisciplinary including Drug Metabolism, Pharmacokinetics and Inflammatory Markers, Immunology. She has more than 140 publications with high citation and few in phase of communication. She also wrote 2 books, and guided and coguided many MD and Ph.D students. She is member of various professional bodies and has participated and presented number of papers in national and international conferences.  She is frequently invited as international speaker. She is awarded with many international and National Scientific Awards for exceptional contribution to research & teaching.