Abstract
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Adiponectin, a major cytokine from adipose tissue and hsCRP, a well established marker of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD), when levels fluctuate from the normal levels in the blood.
Aims and objective: The aim of our study was to evaluate the levels of these parameters and determine their correlation with glycemia in order to assess the cardiovascular risks in the patients with type 2 diabetes mellitus
Materials and methods: The study was conducted in the department of Biochemistry, Santosh Medical college, Ghaziabad with 25 type 2 diabetic patients and 25 age and sex matched controls. Ethical clearance from the institution and informed consent from the patients were taken prior the study. Adiponectin was analysed by ELISA and blood sugar and CRP were estimated by kit based method.
Results: Fasting blood sugar (FBS, 158.2±37.2) and hsCRP (3.97±1.54) were significantly high, adiponectin was significantly low in the patients with diabetes compared to controls (80.52±9.72, 1.27±0.75 and 10.78±1.69 respectively, p<0.05). Adiponectin showed negative correlation with FBS (r=-0.427) and hsCRP (r=-0.336) but the correlation was significant only in case of FBS (p<0.05). hsCRP positively correlated with FBS (r=0.568) and was statistically significant.
Conclusion: The results of our study further support the role of adiponectin and hsCRP as predictive biomarker of CVD risks in the patients suffering from type 2 diabetes.
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