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Speaker at Pharma Conferences - Bhupendra Gopalbhai Prajapati
Ganpat University, India
Title : Abuse-deterrent dosage form technique utilizing a fusion of innovative pharmaceuticals and ion exchange resin

Abstract:

Prescribed drug abuse denotes the potential misuse of pharmacological formulations. Many regulatory agencies are working to improve rules for current and future drug formulations by using some level of abuse deterrent technologies. Opioids are often and widely misused substances because of their prevalent availability on the market. Prevalent abuse tactics encompass the use of excessive pills or modification of dose types. Regulatory bodies mandate that dosage forms have mechanisms to inhibit these techniques. The physical and chemical alterations include several methods, such as pulverization, inhalation, chemical extraction, and syringe delivery. A self-regulating pharmaceutical dosage form was developed using an ion exchange resin and Tapentadol HCl as a model drug. The formulation was developed by integrating a medication with an ion exchange resin complex and other excipients. This approach produces a robust dose form that withstands many physical and chemical methods employed in drug misuse. The final product underwent water extraction at both standard and elevated temperatures (exceeding 90°C) to evaluate its extraction efficacy. The compressive strength of the combination was validated using both a domestic coffee grinder and a laboratory mortar and pestle. The gelation characteristic of Polyox inhibited the solution's potential for intravenous abuse. The formulation was evaluated using an in vitro dissolution study, as specified in the advice for industry issued by the US Food and Drug Administration (FDA). The study compared the dissolution of a single capsule to that of many capsules (more than four) to validate the abuse-resistant properties of the drug-ion exchange resin-based formulation.

Biography:

Dr. Bhupendra Gopalbhai Prajapati is a Professor in the Department of Pharmaceutics at Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He is also acting as Adjunct Professor at Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, 73000, Nakhon Pathom, Thailand. With over 22 years of experience in academia, research, and industry, he specializes in lipid-based formulations, nano/microparticulate drug delivery, and bioavailability enhancement. A recipient of several prestigious awards, including the AICTE Young Teacher Award and Ganpat University's Staff Excellence honors, Dr. Prajapati has published over 320 research/review papers and has contributed to more than 150 book chapters. He actively mentors Ph.D. and PG scholars and serves as editor or section editor for several international publications in pharmaceutical sciences.

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