Title : Effect of the medicinal plant extracts on the crystallization of the phosphate urinary stones
Abstract:
Brushite (DCPD) is considered one of the most important types of phosphate kidney stones, it easily forms large, well-developed crystals well suited for morphological studies. The extracts effect of medicinal plants on brushite crystallization was studied in vitro for some species used in Algerian Sahara traditional pharmacopoeia, Experiments were carried out at 37°C with acidic pH (6.5). The initial pH, temperature, agitation and concentration of constituents were kept constant during a reaction time of 6 h. The effect of aqueous and organic extracts of the selected plants on the morphology of brushite crystals was studied by optical polarizing microscopy, image analysis, micrometric measurement, FTIR spectroscopic analysis. The selected plant extracts showed a significant inhibitory effect on brushite crystallization presented as total inhibition of all crystallization phases. For the other extracts, the effect manifested in the decrease of the size and the number of crystals and aggregates brushite.
