Introduction: Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients with advanced fibrosis and poor cardiovascular outcomes. There [....] » Read More
In this keynote talk, the traditional disc diffusion-test bioassay is revisited within the perspective of using a mathematical approach grounded on the standard as well as on the modified Hill model. Importantly, the Hill model was established in 1910 to account for the binding o [....] » Read More
This research explores the creation of a novel exosome delivery platform, termed Exo-ITC, tailored for use in dermatology. Exosomes, as extracellular vesicles, are pivotal in intercellular communication and exhibit substantial therapeutic potential in regenerative medicine and de [....] » Read More
Understanding drug transport in plasma is pivotal to optimizing therapeutic outcomes, as it governs drug distribution, efficacy, and clearance. A key factor in this process is protein binding, where drugs reversibly interact with plasma proteins such as albumin and alpha-1-acid g [....] » Read More
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D spending in 2026 are Roche, Johnson & Johnson, Merck & [....] » Read More
The morphology of nanosystems is one of the Critical Quality Attributes (CQAs) of the nanoformulations, affecting the interactions of cellular membranes as well as the release of the encapsulated active substances. Hybrid systems are mixed systems composed of different in-nature [....] » Read More
One of the primary challenges in pharmaceutical dosage form development is the poor solubility of certain drugs, particularly those classified as Biopharmaceutics Classification System (BCS) Class IV. These drugs exhibit low solubility and permeability, resulting in suboptimal ph [....] » Read More
Mineral and metallic nanomedicines are a precious resource found in the Ayurvedic medical system. Rasashastra is an Ayurvedic branch that deals with the preparation and therapeutic use of nanomedicines. A weak interdisciplinary collaboration between science and Ayurveda ultimatel [....] » Read More
Background: Neurodegenerative diseases, such as Alzheimer’s disease (AD), are marked by the accumulation of proteins with altered physicochemical properties in the brain and other tissues, leading to progressive neuronal decline. This study explores the therapeutic potentia [....] » Read More
Doxorubicin (DXR) is a powerful chemotherapeutic drug commonly used to treat cancers such as breast cancer, bladder cancer, Kaposi's sarcoma, and lymphoma. However, its clinical use is often limited by severe side effects, including cardiomyopathy, bone marrow suppression, an [....] » Read More
Title : Ectopically expressed olfactory receptors as an untapped family of drug targets and discovery of agonists and antagonists of OR51E1, an understudied G Protein-Coupled Receptor
Vladlen Slepak, University of Miami Miller School of Medicine, United States
Over 30% of pharmaceuticals act on G protein-coupled receptors (GPCRs), the largest family of human genes (~800). About 50% of GPCRs (~400) are Olfactory receptors (ORs); these GPCRs were originally discovered in the nasal epithelium, where they mediate the sense of smell. [....] » Read More
Title : Emerging formulation and delivery applications of Vitamin E TPGS
Andreas M Papas, Antares Health Products, United States
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through design-inspired biotech- & biopharma-driven applications and upgraded business marketing to secure the human healthcare and biosafety
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Macitentan/Tadalafil Combination– An additional value in pharmacotherapy of pulmonary arterial hypertension
Miroslav Radenkovic, University of Belgrade, Serbia
Pulmonary arterial hypertension (PAH) remains a devastating disease with high morbidity and mortality. It is uncommon, progressive and life-threatening blood vessel disorder differentiated by the constriction of minor pulmonary arteries and elevated blood pressure in the pulmonar [....] » Read More
Title : The promise of nanotechnology in Personalized & Precision Medicine: Drug discovery & development being partnered with nanotechnologies via the revolution at the nanoscale
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
A new systems approach to subclinical, predictive and/or diseased states and wellness resulted in a new Hi Tech trend in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, despite breakthroughs in designed-driven research that have led to an in [....] » Read More
Title : Antibody-proteases as translational tools of the next-step generation to be applied for biopharmacy-related and precision medical practice
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
The identification, impact and implementation of diagnostic, predictive and prognostic biomarkers of the next step generation becomes the Holy Grail of platforms, algorithms and protocols, which are the crucial for Personalized & Precision Medicine (PPM). High impact of Ab-pr [....] » Read More
Title : Navigating the regulatory landscape for nanotechnology-based pharmaceuticals: challenges and strategies for harmonization
Srividya Narayanan, Northeastern University, United States
Nanotechnology has revolutionized pharmaceutical and biomedical applications, offering a plethora of opportunities in drug delivery, medical imaging, and cancer therapy. However, the unique properties of nanomaterials present significant regulatory challenges that must be address [....] » Read More
Title : Strategies for addressing latent HIV-1 microglial cell reservoirs in adolescents and young adults with Neuro-HIV: Steps towards an HIV cure
Aarti V Belgamwar, Shri Vile Parle Kelvani Mandal’s Institute of Pharmacy, India
Although successful strides have been made in the HIV-1 response, ending AIDS threat by 2030 is a significant challenge, as HIV-1 infections among adolescents and young adult have not decreased fast enough to curb the epidemic. Globally, of the estimated 39.0 million people livin [....] » Read More
Title : Proposomes as a promising approach for topical application of Allantoin intended against ultraviolet induced photoaging
Eman Shalaby, National Research Centre, Egypt
Photoaging is one of the most common issues in the world, affecting nearly all women. The term "photoaging" describes the early aging of skin brought on by excessive exposure to ultraviolet radiation. Our study's objective was to evaluate Allantoin proposomes' a [....] » Read More
Title : Trends in antimicrobial resistance in Gaza Strip, 2020-2022
Hashem M Mansour, Indonesian Hospital, State of Palestine
Background: In this study, we analysed the data on antimicrobial resistance in the bloodstream. This study aims to evaluate the bacterial resistance in the Gaza Strip and compare with that in other countries. Methods: This study was conducted retrospectively in the Indonesian [....] » Read More
Title : Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce enos phosphorylation in vascular endothelial cells
Haitham A Saleh, Qatar University, Qatar
Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as atherosclerosis, coronary artery disease, and hypertension. [....] » Read More