OR51E1 is a G protein-coupled receptor that belongs to the family of olfactory receptors, but is found in a few tissues outside the nasal epithelium. It widely reported as a prostate cancer–associated marker, yet its functional role has remained unclear due to the lac [....] » Read More
For realizing pervasive and ubiquitous health and social care services, health and social care system have to undergo an organizational, methodological and technological transformation towards personalized, participative, preventive, predictive precision medicine. For designing a [....] » Read More
Raman and surface-enhanced Raman scattering spectroscopy have become valuable tools in pharmaceutical chemistry because they combine molecular selectivity, limited sample preparation and the possibility of analysing compounds in different physical states. This contribution presen [....] » Read More
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of highly promising characteristics that we are exploring towar [....] » Read More
Objective: The utilization of herbal medicines has risen globally. Recently, the possible adverse effects of certain herbs have been observed, particularly concerning hepatotoxicity associated with the consumption of herbal treatments. This review aims to assess the evidence [....] » Read More
The present talk will discuss experimental data regarding successful fabrication of a novel Cu2+-complex of nitrogen-rich polymer nanodots, with a mean diameter of about 20 nm extracted from transmission electron microscopy (TEM) micrographs and 350 nm obtained from dynamic light [....] » Read More
Diagnosis of lung cancer often occurs in its later disease stage. The prognosis for long term survival for patients with lung cancer is very poor. Early detection of lung cancers can be associated with a reduction in mortality and an improvement in patients’ health-related [....] » Read More
Silk fibroin (SF) and chitosan (CS) are promising biopolymers for biodegradable scaffolds in regenerative therapies. Here, we produced SF/CS composite plugs at 70:30 and 60:40 ratios and compared them to single-polymer controls to examine their physicochemical traits and prelimin [....] » Read More
The Medicines Discovery Catapult (MDC) is a UK-based national life sciences service, headquartered in Alderley Park, supporting innovators across the full drug discovery and early development pathway through R&D consultancy, Discovery Laboratories and National Programmes. Our [....] » Read More
Recently, multi-drug resistant (MDR) bacteria are responsible for a large number of infectious diseases that can be life-threatening. Globally, new approaches are targeted to solve this essential issue. This study aims to discover novel antibiotic alternatives by using the whole [....] » Read More
Plant polyphenols comprise several major classes, including flavonoids, phenolic acids, stilbenes, lignans, and related compounds. Beyond their classical role as antioxidants, they act as pleiotropic modulators of interconnected signaling, metabolic, and epigenetic pathways, incl [....] » Read More
Tea tree oil (TTO), derived from Melaleuca alternifolia, exhibits antimicrobial, antifungal, antiviral, and anti-inflammatory properties. However, its effectiveness is limited due to its susceptibility to oxidation, volatility, and thermolability. In pharmaceutical applications, [....] » Read More
The development of modern therapeutics relies heavily on Quantitative Structure-Activity Relationship (QSAR) methodologies to guide rational drug design, optimize lead compounds, and minimize empirical trial-and-error. This presentation provides a comprehensive review of QSAR ana [....] » Read More
This presentation focuses on the design, evaluation, and computational analysis of thiazolo[4,5-b]pyridine-2-one derivatives, with particular emphasis on in silico approaches used to predict their biological activity. While synthetic and pharmacological studies were performed, th [....] » Read More
Cannabinoids are the primary active compounds in Cannabis sativa, which has been used for over 4000 years as a recreational drug. The main psychoactive constituent of hemp is Δ9-tetrahydrocannabinol (Δ9-THC). In plants, it occurs as the non-psychoactive tetrahydrocann [....] » Read More
Intranasal drug administration has gained considerable attention as a non-invasive approach for delivering therapeutic agents directly to the central nervous system (CNS). This route provides the potential to bypass the blood–brain barrier and improve drug targeting to the [....] » Read More
Solar ultraviolet (UV) radiation is a major environmental toxicant that contributes to inflammation, immunosuppression, and carcinogenesis. Previous studies suggest that UVB-induced oxidative stress generates oxidized lipids with platelet-activating factor (PAF) agonistic activit [....] » Read More
Background & Rationale: Regulatory agencies including the FDA, EMA, and ICH are increasingly recognizing the value of Artificial Intelligence (AI) and Digital Twin (DT) technologies in pharmaceutical development. FDA's Emerging Technology Program and guidance on Phar [....] » Read More
Introduction: Burn wound management remains a considerable clinical challenge, particularly in cases where rapid tissue regeneration, effective infection control, and the prevention of excessive scar formation are required. Disruption of the skin barrier markedly increases the ri [....] » Read More
This study presents a machine learning approach to classify diabetes status using the CDC BRFSS 2015 dataset, which includes over 250,000 self-reported health records across 22 variables. The goal was to develop a multi-class classification model to identify individuals as No, Ye [....] » Read More
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder in the world. While it primarily hinders motor functions, PD also causes cognitive dysfunctions which can progress to severe conditions like dementia. Despite the significant impacts of cognitive [....] » Read More
Sepsis is a major health problem worldwide. It is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-related deaths represent 19·7% of deaths from all causes worldwide. Outcomes for patients suffering from sepsis are p [....] » Read More
The incidence rate of skin cancer is very high around the globe, making melanoma and non-melanoma skin cancer serious concerns to the community at large. Current methods used for managing these cancers are limited by problems such as toxicity of drugs to other body organs, inabil [....] » Read More
Binding of drugs to plasma proteins plays a critical role in determining pharmacokinetics, bioavailability, and therapeutic efficacy. Among plasma proteins, Human Serum Albumin is the primary carrier responsible for transporting a wide range of endogenous compounds and pharm [....] » Read More
Based on existing diagnostic data, Breast Cancer (BC) stands second globally and is also a significant contributor to cancer-related deaths in women1 in several countries including India, necessitating research endeavours in terms of identifying mechanistically relevant targets a [....] » Read More
Conventional antibiotic efficacy metrics fail to capture the mechanopharmacology of bladder infections, where pathogens persist within protected intracellular and subepithelial reservoirs that drive chronic disease. The bladder uroepithelium is a stratified, mechanosensitive barr [....] » Read More
A series of novel 3-spiro-2-oxindoline derivatives incorporating an aromatic hydrazide linker were rationally designed and synthesized as potential VEGFR-2 inhibitors. This work specifically aimed to evaluate the influence of linker rigidity on biological activity, in comparison [....] » Read More
An effective nucleic acid therapeutic delivery system must ensure consistent performance across both healthy and diseased liver conditions, support repeat dosing without inducing toxicity, and minimize immunogenic responses. In hepatic applications, clinical validation of two key [....] » Read More
Hypertension is a lifestyle disorder. Mostly the disorder is asymptomatic until it gets diagnosed. Hypertension for a longer duration if gets uncontrolled can cause the problems to the eye, kidney blood vessels, and other organs. It may cause heart attack, kidney failure, or [....] » Read More
Hypertension is a major chronic cardiovascular disorder requiring prolonged pharmacotherapy and consistent maintenance of therapeutic plasma concentrations to achieve optimal clinical outcomes. Conventional immediate-release antihypertensive formulations often result in fluctuati [....] » Read More
Formulating plasma proteins as liquid dosage forms is challenging due to limited excipients and risks of physical and chemical instability, including aggregation and loss of efficacy. Strategies such as DoE, QbD, and rational design approaches, combined with stabilizers, buffers, [....] » Read More
Pharmaceuticals are essential for maintaining human health and have become an indispensable part of modern life. However, their widespread and often uncontrolled use has led to growing concerns about environmental contamination and potential risks to human health. In recent years [....] » Read More
Oxazolone derivatives have gained significant attention due to their wide spectrum of biological activities, particularly anticancer potential. Breast cancer remains a leading cause of mortality among women, highlighting the need for novel therapeutic agents. In this study, 36 de [....] » Read More
Background: Cannabis has been employed medicinally across nearly all ancient civilizations, with references in the Vedas and classical Ayurvedic texts. Traditionally, it was advocated for acute and chronic pain management, insomnia, and anxiety. However, during the rise of modern [....] » Read More
Otitis media remains one of the most common ear infections in young children, and conventional otic formulations often suffer from short residence time and rapid drainage from the ear canal, limiting therapeutic efficacy. This work aimed to develop and evaluate a herbal in-situ t [....] » Read More
Background: Arteether (ART) is a potent antimalarial drug, but its clinical utility is limited due to low aqueous solubility and poor oral bioavailability. This study aimed to develop an ART-loaded nanoemulsion (ART-NE) to improve systemic exposure and antimalarial efficacy [....] » Read More
Purpose: Paediatric tuberculosis (TB) treatment is challenged by the need for age-appropriate dosage forms, flexible dose adjustment, and improved patient adherence. Three-dimensional (3D) printing has become an attractive technology for the production of customized drugs th [....] » Read More
Nanotechnology has emerged as a transformative approach in pharmaceutics and drug delivery systems, enabling precise targeting, controlled drug release, and improved bioavailability of therapeutic agents. This presentation explores recent advancements in nanoparticle-based drug d [....] » Read More
Title : Tailored cellular environments to enable drug design
Lan Wang, Paretor LLC, United States
Over the past 50 years, drug delivery has evolved from localized injection to basic pharmacokinetic optimization to targeted intracellular delivery of therapeutics. While these advancements have been critical for supporting therapeutic efficacy and minimizing off-target effects, [....] » Read More
Title : Application of quality by design for pulmonary liposomes: Preliminary study to nano in-microparticle
Lucas Amaral Machado, University of Sao Paulo State – UNESP, Brazil
Introduction: Pulmonary surfactants in liposomes production became relevant components due to their compatibility with the pulmonary environment. However, the understanding of critical process parameters (CPP) needs to be elucidated. Thus, Quality by Design (QbD) combined with a [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model based on design-inspired biotech- & biopharma-driven applications to secure the human healthcare and biosafety
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, InMedStar and Biona, Russian Federation
Despite breakthroughs in research that have led to an increased understanding of PPM-based human disease, the translation of discoveries into therapies for patients has not kept pace with medical need. Modern drugs are crucial in the field of PPM-guided drug therapy and are curre [....] » Read More
Title : Structure-based discovery of kinetic stabilizers for transthyretin amyloidosis
Salvador Ventura, Universitat Autònoma de Barcelona, Spain
Transthyretin amyloidosis (ATTR) is a group of fatal protein misfolding disorders caused by the dissociation and aggregation of the transthyretin (TTR) tetramer. Tetramer destabilization, driven by aging or pathogenic mutations, precedes amyloid formation, making native-state [....] » Read More
Title : An injectable CarboCell depot technology for local, sustained dual-antibiotic delivery in bone infections
Niranjan G Kotla, Technical University of Denmark (DTU), Denmark
Chronic bone infections remain difficult to treat, as systemic antibiotic therapy often fails to achieve sufficient local drug concentrations in poorly vascularized, infected bone while simultaneously exposing patients to systemic toxicity risk. Carbohydrate-derived lipophilic ma [....] » Read More
Title : Novel fabrication of adaptive transdermal technologies for drug delivery
Zeeshan Ahmad, University of Manchester, United Kingdom
Transdermal drug delivery systems (and technologies) have undergone substantial transformations over the last decade due to advances in 3D Printing, Micromoulding and other novel processing technologies. This presentation will focus on selected developments; detailing how emergin [....] » Read More
Title : Rational optimization of antibody–cyanine bioconjugates for targeted theranostic drug delivery and photo/sono activation
Amartya Sanyal, Ariel University, Israel
Photodynamic therapy (PDT) is a well-established treatment modality; however, its clinical translation is limited by poor light penetration in deep tissues. Sonodynamic therapy (SDT), which utilizes ultrasound as an external trigger, offers a promising alternative due to its abil [....] » Read More
Title :
Ignacia Paz Torres Fredes, University of Chile, Chile
Will be Updated Soon...
Title : Design and characterization of gum arabic buccal films for protein drug delivery
Krisztian Pamlenyi, University of Szeged, Hungary
Oral mucoadhesive drug delivery systems, particularly buccal films, have gained increasing attention as promising alternatives to conventional dosage forms. These flexible systems adhere to the oral mucosa for extended periods without causing discomfort, thereby enhancing the abs [....] » Read More
Title : Biocompatible synthesis of non crystalline iron oxide nanoparticles with stable colloidal properties
Lan Wang, Paretor LLC, United States
Biocompatible iron oxide nanoparticles (IONPs) are widely used in targeted and responsive delivery, yet conventional formulations adopt crystalline spinel phases that generate magnetic interactions and aggregation, constraining spaciousness and colloidal stability. To overcome th [....] » Read More
Title : Design and optimization of a nanotechnological platform for future delivery of Sarcomphalus joazeiro (Mart.) extract in dental bleaching
Lucas Amaral Machado, University of Sao Paulo State – UNESP, Brazil
Although effective in removing stains from teeth, peroxides can trigger severe side effects, such as gum inflammation and dental hypersensitivity, due to free radical penetration into dentinal tubules. In this scenario, Sarcomphalus joazeiro stands out as a promising alternative; [....] » Read More
Title :
Ignacia Paz Torres Fredes, University of Chile, Chile
Will be Updated Soon...
Title : Antibody proteases as translational tools of the next step generation to be applied for biopharmacy related and precision medical practice
Sergey Suchkov, N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, InMedStar and Biona, Russian Federation
High impact of Ab-proteases is valuable to monitor both clinical and subclinical courses of chronic autoimmune inflammation to predict stepwise transformations of the course, starting from the pre-illness and to prognosticate the clinical illness finally. This infor-mation would [....] » Read More
Title : Non-crystalline stabilization of iron-oxide nanoparticles enables a versatile platform for carrier-dependent and carrier-free drug delivery
Lan Wang, Paretor LLC, United States
We investigated alternative routes for tuning nanoparticle drug-delivery behavior by deliberately disrupting spinel lattice formation during iron-oxide: magnesium synthesis. Under constrained, automation-compatible co-precipitation conditions, defective ferrite assembly prevented [....] » Read More
Title : Azobenzene-enriched PEG-PLGA micelles as a light-responsive drug delivery platform: Effect of light on biological activity
Mila Radan, University of Split, Croatia (Hrvatska)
Azobenzene derivatives have the potential to enable light-induced modulation of biological activity. In this study, azobenzene-enriched PEG-PLGA micelles were developed as a delivery system for a selected anticancer agent, with the aim of improving its delivery properties and ena [....] » Read More