HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
Speaker at Drug Delivery Events -  Andreas M Papas
Antares Health Products, United States
Title : Emerging formulation and delivery applications of vitamin E TPGS


Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glycoprotein mediated drug efflux and other mechanisms which reduce first-pass metabolism and facilitate its transport, cell uptake and function. The safety and efficacy of TPGS expanded research and development in major areas.

The presentation will review emerging applications of vitamin E TPGS which include:

• Multi-drug resistance and first-pass metabolism and their effect on drug efficacy, especially in cancer chemotherapy.
• Formation of prodrugs and drug conjugates and their role on drug efficacy and adverse effects.
• Synthesis of TPGS based polymers and their role in drug encapsulation, intracellular uptake, therapeutic effects, and safety.
• Excipient in nanomedicine and targeted drug delivery systems for increased therapeutic effect and reduced toxicity.
• Interactions with active pharmaceutical ingredients through antioxidant function and other mechanisms.
• Function as active pharmaceutical ingredient by selective induction of apoptosis of some cancer cells lines.
• Parenteral administration, a major component of the emerging applications of drug formulation including mRNA, peptide, and other novel drug categories.


Dr. Papas is Adjunct Professor of the College of Medicine, East Tennessee State University and CEO and member of the Board of Directors of Antares Health Products, Inc. A Fulbright Scholar, Dr. Papas is a graduate of the University of Illinois and author of The Vitamin E Factor paperback and editor of the scientific book Antioxidant Status, Diet, Nutrition and Health. Dr Papas also founded YASOO Health and led the company as President and Chair of the Board of Directors. He developed product concepts and managed successful commercialization including formulation, clinical evaluation supported by the National Institutes of Health and the Cystic Fibrosis Foundation, stability and safety testing, pilot, and commercial production.