Hybrid compounds: A useful strategy to overcome limited pharmaceutical profile

Title : Hybrid compounds: A useful strategy to overcome limited pharmaceutical profile

Abstract:

Hybrid compounds are artificial scaffolds made of two or more pharmacophores that are jointed or overlapped in a single chemical entity. The strategy of combining two different and independently acting compounds into one covalently linked hybrid compound aims to increase the pharmacokinetic and pharmacodynamic profiles with respect to the sum of each individual moiety. Hybrid compounds find application in many areas of medical interest:  oncology, microbiology, cardiology, neurology, anti-inflammatory, anti-infectious, platelet anti-aggregating, analgesic, cardio- and neuroprotective properties.
In this presentation the results obtained in a recent research work in the field of wound healing are reported. Starting from the well-known biological properties of the caffeic acid and the antimicrobial activity of heterocycles such as quinolines, twelve novel molecular hybrids were designed and synthesized by combination through an ester or an amide linker. The detailed synthetic process, the in vitro biological properties are described, as well as the improved pharmacokinetic profile and chemical and thermal stability. An interesting SAR is discussed to suggest a promising multi-targeted approach for enhanced wound healing.
Audience Take Away Notes:

• The advantages and practical application of hybrid drugs in different medical fields
• Information on the validity of the use of molecular hybrids in the pharmaceutical research
• Description of the design and results obtained in a concrete case of scientific application of natural phenol hybrids
• Interesting ideas for the design of novel molecules of pharmaceutical interest, not limited to the regenerative medicine field only
• Description of the rationale of the project as a starting point and practical suggestions on the synthesis technique

Biography:

Prof. Barbara De Filippis got her PhD in Pharmaceutical Sciences at the University of Chieti (Italy) and is currently an Associate Professor in Medicinal Chemistry. Her research work is focused on the design and synthesis of small molecules with anticancer and antimicrobial activities. Her studies are related on derivatives of natural phenols, as resveratrol and caffeic acid. She is author/co-author of many international papers and guest editor and reviewer for many journals.