Crystallographic in pharmaceutical filed: new frontiers

Title : Crystallographic in pharmaceutical filed: new frontiers

Abstract:

Most commonly produced and marketed drugs are formulated with the pharmacologically active ingredient in solid form (crystalline or amorphous). The solid form is carefully chosen for its characteristics, to increase the stability of the drug, facilitate its formulation, optimize its dosage and simplify the use method. Now the importance of research (aimed at identifying, preparing and formulating new drugs) is recognized, both in the academic and productive fields, the pharmaceutical chemist is delegated with the task of finding new and rapid methods of investigation of solid forms. In this study, some aspects of the theory of crystal chemistry of drugs, techniques for identification and characterization are discussed and some examples of crystallization and characterization of drugs are reported. The frontier of knowledge in the development of new "crystallographic" theories constitutes the powerful numerical algorithms for data analysis. Today synchrotrons, computing power and new approaches to the structural problem in the pharmaceutical field are starting to have a new vision in the pharmaceutical crystal chemistry.
Keywords: crystallographic, chemical characterization pharmaceutical solid forms, algoritms.
Audience Take Away Notes:

• Knowledge of aspects of the theory of crystal chemistry of drugs
• Increase in knowledge of characterizations of pharmaceutical compounds
• Knowledge in the frontier of the development of new "crystallographic" theories

Biography:

Maria Cristina Gamberini is a tenured researcher in Pharmaceutical Chemistry and Technology at the Department of Life Sciences, University of Modena and Reggio Emilia. She holds a PhD in Pharmaceutical Sciences and has extensive experience in the structural characterization of bioactive and pharmaceutical compounds. Her research focuses on Raman and SERS spectroscopy, DFT calculations, molecular docking, polymorphism, co-crystals, antimicrobials and drug–metal interactions. She has published more than 90 peer-reviewed papers and obtained the Italian National Scientific Qualification for Associate Professor in Pharmaceutical Chemistry and Technology.