Title : Pharmaceutical continuous manufacturing: The interaction between different units and tablet properties
Abstract:
In a multi-processes pharmaceutical continuous tablet production line such as ConsiGmaTM -25, the quality of the final tablet is a function of different processes and formulation parameters of different units. The effect significance of each unit depends not only on the unit itself but also on the overlapping between different units. In this study, different process parameters of each unit within ConsiGmaTM -25 and Modul P tablet press were changed within a wide range and the effect of this change on the tablet strength was investigated and compared. It was found that some units have more effect than others. In terms of process parameters effect, the tablet press has the highest effect on tablet properties followed by the fluidized bed dryer then twin screw granulator then mill, and blender. The study also covers the effect of formulation parameters such as liquid-to-solid ratio (L/S) and using different formulations such as different percentages of excipients which also could affect the tablet strength and whole manufacturing process.
Audience Take Away Notes:
- How to control the product quality
- Tablet manufacturing is widespread in many pharmaceutical industries
- Understanding the relation between critical process/formulation parameters and critical quality attributes is useful in designing the particle and tablet properties
