Surface chemistry and particle interactions in materials and their impact on powder performance

Title : Surface chemistry and particle interactions in materials and their impact on powder performance

Abstract:

Surface and physico-chemical properties are critical in formulation and in processes involving the handling, processing, packaging, shelf-life and bioavailability of medicines. In this presentation, we will explore and discuss the intricate ways in which interactions at the surface chemistry of biomaterials and multicomponent systems dictate powder behaviour. Highlighting how the role of surface interactions, environmental conditions (%RH) can help or hinder powder flow through promoting particle agglomeration, mixing, and suppressing electrostatic charge on particle cohesion, adhesion to processing equipment, and friction between particles. This comprehensive analysis can deliver a fundamental insight into the critical factors for identifying powder behaviour problems. By understanding these interactions, we aim to formulate targeted strategies to enhance powder performance such as flow properties, prevent undesirable agglomeration, thereby overcoming formulation, processing, manufacturing, stability, release, dissolution and bioavailability challenges.
Audience Take Away Notes:

• The audience will gain awareness of characterization tools and understand the additional insights they offer.
• The audience may wish to explore further on the topic and perhaps, if appropriate, implemented it in their job
• This research could be utilized by other faculty to expand their research and teaching
• By having a robust understanding of their systems, it is possible to do it right first- time
• It is designed to improve design accuracy and provide new insights for design problems

Biography:

M. Teresa Carvajal is a Faculty Member at the Agricultural and Biological Engineering at Purdue University. She worked in the pharmaceutical industry, Roche, Bayer and Transave for a total of 14 years prior to joining Purdue. She graduated with a MS in Physical Pharmacy, from the University of Arizona, USA and with a PhD in Powder Pharmaceutical Technology at the University of Bath, UK. Tere’s research group on material sciences focuses on microstructure, surface/interface interactions and energetics, and their impact on powder bulk properties during formulation, processing and manufacturing. She has authored or co- authored more than 70 peer reviewed articles.