Title : Evaluation of the wound healing activity of Hyoscyamus nigar seed powder on the wistar albino rats
Abstract:
Wounds remain a huge public health issue, at least in terms of morbidity and long-term disability, throughout the world, especially in developing countries. Plant-derived natural products are significant as sources of medicinal agents and models for the design of new remedies. This study was done to prove the effectiveness of Hyoscyamus niger on the management of wounds by evaluating the wound-healing activity of Hyoscyamus niger seed powder on wistar albino rats. Along with that compare the effectiveness of Hyoscyamus niger seed powder between male and female rates based on Unit Healing Time and wound closure rate. Wister albino rats weighing 200-250g were used for the experimental study. Animals were divided into three groups each with 6 animals. Each group consists of 3 male and 3 female rats. The animals of group A were left untreated and considered as control. Group B served as standard and it received cicatrix powder. Group C was considered as a test and treated with a prepared test drug. The independent t-Test analysis of the wound circumferences of the standard and the test drug initially showed a significant values of 0.374 and 0.305 which is much higher than the p-value of 0.05. Whereas the final readings of the wound circumference between the test drug and the standard drug showed a significant values of 0.001 and 0.004. In other words, which indicates that the test drug is much more effective in the treatment of wound healing than the standard drug. The present study revealed Hyoscyamus niger seed powder has a significant accelerating wound healing activity in excised wound models in wistar albino rats also readings show the female rats have a higher healing rate than the male rats. The readings of drug effectiveness and Unit Healing Time lead to the conclusion that, the test drug is more effective for wound healing than stranded.It confirms the potential value of Hyoscyamus niger seed powder to be considered as a natural product for wound healing.
