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Speaker at Pharmaceutics and Novel Drug Delivery Systems 2023 - Alireza Kamali
Arak University of Medical Sciences, Iran (Islamic Republic of)
Title : Comparison of dexmedetomidine and propofol with ketofol in sedation of candidates for cataract surgery


Introduction: Cataract is the most common cause of vision loss in the world and about 30 to 40 million people in the world are scientifically blind, about 45% of which is cataract. A cataract is one of the most common surgeries performed in the elderly. The purpose of prescribing anesthetics to patients undergoing surgery is to create sedation in the patient by maintaining safety and achieving the desired outcome. The aim of this study was to compare the effects of dexmedetomidine and propofol/ketofol on the sedation of patients undergoing cataract surgery.

Materials and Methods: This randomized, double-blind clinical trial was performed on patients undergoing cataract surgery at Amirkabir Hospital in Arak, Iran. Patients were randomly divided into three groups using random allocation software and block pattern to receive dexmedetomidine, propofol/ketamine or propofol. Baseline systolic and diastolic blood pressure, heart rate, and oxygen saturation were measured and recorded every 2 minutes to 10 minutes, and then every 5 minutes until the end of surgery and at recovery time. Sedation, pain and surgeon satisfaction levels in patients were measured and recorded. Finally, the information was analyzed using SPSS software version 22.

Results: The duration of surgery, oxygen saturation percentage and surgeon satisfaction were not statistically significant between the three groups (P <0.05). The heart rate in the dexmedetomidine group was lower than the other two groups from 4 minutes (P <0.05).  The pain was recorded to be lower in the dexmedetomidine group (P <0.05). Furthermore, the Ramsey scale was higher in the dexmedetomidine group (P <0.05).

Conclusion: Our result demonstrated that dexmedetomidine reduced pain and reduced heart rate. Furthermore, dexmedetomidine provided a high level of sedation. Dexmedetomidine can be applied effectively for sedation and pain management according to the patient's condition. But there was no difference between the three drugs in terms of surgical satisfaction, and all three drugs were suitable for surgery.


Dr. Alireza Kamali, specialist and associate professor of anesthesia and special care at Arak University of Medical Sciences, Iran. He is 47 years old and has been a member of the academic staff of the university since 2012, and my specialty is cardiac anesthesia. Since 2010, he has been the head of the cardiac and anesthesia ICU department of the university, and since the same year, he has many research projects and articles in the field of anesthesia and cardiac anesthesia. During these almost 10 years, he has had 73 articles in the Scopus profile and 145 articles in the Google Scholar profile, 56 articles in the PubMed profile and 52 articles in the ISI profile in the field of anesthesia and special care and cardiac anesthesia.