Inflammation is a normal adaptive response to traumatic, infectious, post-ischemic, toxic or autoimmune injury. Uncontrolled inflammation, however, results in disease, and most of diseases have been shown to have an inflammatory component. Identifying biological molecules that me [....] » Read More
Vaccines and vaccination are important for the prevention of infectious diseases. In the history of vaccination, we have savings of lives of people of different ages from children aged 0 days and the very old people. The vaccine against rotavirus: Before using the rotavirus vacci [....] » Read More
Self-emulsifying system-based lipstick may prove to have potential of enhancing the moisturizing characteristics and deliver the hydrophobic drug antifungal drugs for the treatment of lip fungal infections. In this study, the self-emulsifying (SEDDs) mixture of Ketoconazole was o [....] » Read More
Harnessing the power of the immune system to target cancer has been the aim of scientific research for over centuries. The irruption of immune checkpoint inhibitors (ICI) in 2011 has changed the therapeutic landscape of several tumors and, consequently, the prognosis of cancer pa [....] » Read More
A dinuclear Cu(II) species [Cu2L2(H2O)2(N3)](NO3)2 (L = 2,6-bis(N-ethylpyrrolidine-iminomethyl)-4-methyl-phenolato) where two Cu centers are bridged by phenoxido and l1,1-azido bridges with Cu–Cu separation of 3 Å have been synthesized with the view to explore t [....] » Read More
The present work aims to develop a self-micro emulsifying drug delivery system (SMEDDS) to improve in-vitro dissolution of Clopidogrel Bisulfate an Anti-platelet agent, belonging to BCS class II. Initially, solubility studies were performed to identify the solvents showing the hi [....] » Read More
Diabetes is a metabolic disorder characterized by hyperglycemia and affecting more than 460 million people worldwide. Uncontrolled diabetes can lead to secondary complications such as non-healing diabetic foot ulcers (DFUs) due to ischemia and peripheral neuropathy. Non-healing D [....] » Read More
Butea monosperma (Family Fabaceae) popularly known as ‘dhak’ or ‘palas’, commonly known as ‘Flame of forest’ is an important plant and is extensively utilized for lac cultivation. Lac cultivation plays an important role in the tribal economy. B [....] » Read More
FDF is also knows as oral wafers which is bunch of thin polymeric film which is now gaining widespread interest in pharmaceutical industry. It is novel formulation and now accepted by various customers for supplying vitamins and self-care products specially. In present day, it is [....] » Read More
Asthma and COPD are among the most common chronic non-communicable diseases. Many different environmental and individual factors are involved in their development. The main goals of treatment are to prevent symptoms of the disease, reduce the risk of exacerbations, and improve th [....] » Read More
Paraphenylenediamine (PPD) is a chemical substance that is used in hair dye because it is a permanent dye that gives a natural look, and the dyed hair can also be shampooed or permed without losing its colour. PPD-containing hair dyes have been associated with canc [....] » Read More
Starch is known to be one of the most abundant carbohydrate molecules found in tropical roots and tubers, grains, and cereals. Various botanical sources of starch, including maize, potato, corn, wheat, etc., have been used as a staple food for millions of people for centuries. Th [....] » Read More
A series of fifteen (Z)-N-substituted-4-(pyridin-2-yl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-2-amine, was designed, screened computationally and synthesized. Structures of the compounds (1-15) were elucidated using spectroscopic methods like FT-IR, NMR (1H & 13C), and ma [....] » Read More
The antibiotic resistance of bacterial strains evolves continuously. The nosocomial infections and the infections of immune-compromised patients put a lot of pressure on healthcare professionals. Very often the source of infection remains unclear but the hospital environmen [....] » Read More
The main aim of this research is to provide literature of the Ocimum plant, to know the significance of the Ocimum species carried out by pharmacognostical study and experimental design for GC-MS.Ocimum genus is very important for its therapeutic potential. among the most importa [....] » Read More
Malignancies located in the brain are difficult to treat, because most therapeutic agents are unable to enter the brain parenchyma from the circulation, due to the obstacle placed by the blood-brain barrier (BBB). Intranasal delivery of anticancer agents holds potential as a more [....] » Read More
Asthma is a chronic disease that causes inflammation of the airways and makes it difficult to breathe. The best way to manage asthma is to avoid triggers, take medication to prevent symptoms, and control asthma attacks. The inhalation route is frequently used to administer drugs [....] » Read More
The most effective method of treating allergic diseases is allergen-specific immunotherapy (SIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems such as liposomes, dendrimers, nanoparticles, etc. can be used. Today [....] » Read More
Since the success of immune checkpoint blockade and chimeric antigen receptor T cell therapy, over a dozen immunotherapies have been approved in the past few years, and thousands of immunotherapeutics are currently in the development pipeline. However, immunotherapy benefits only [....] » Read More
The necessity of new systems for drug delivery in children and specific procedures is clearly needed, in the case of children the difficulty of the correct dose administration is a problem when the drug carrier is not easy to administrate by a non-specialized adult. Mucoadhesive [....] » Read More
Nocturnal asthma mainly known as nighttime asthma, it is mainly occur during sleep. The mechanism of this is related to the circadian rhythms that may influence mediators and inflammatory cells, cholinergic tone and hormonal changes. Chronotherapeutics is defined as a treatment s [....] » Read More
Psoriatic arthritis is an autoimmune disease of the joints; it can lead to persistent inflammation, joint damage and disability. Apremilast (APR) was the first FDA-approved oral anti-psoriatic arthritis drug. It APR immediate release tablets Otezla® have 20-33% bioavailabilit [....] » Read More
The present investigation aimed to develop an antibiotic and a phytoconstituent combination loaded gastric floating microsponge for the effective eradication of Helicobacter pylori infection by the synergistic effects of the loaded drugs. The microsponge formulations were prepare [....] » Read More
FP (fluticasone propionate) is a synthetic fluorinated cortisol derivative with a strong anti-inflammatory effect. In inhaled form, it is used to treat asthma, and less frequently, to treat COPD. Typically the DPI inhaler used for administering dose of drug is provided in the sta [....] » Read More
Title : Development and Evaluation of Structured Strategic Approach for successful accomplishment of Risk-Based Monitoring model from clinical trial inception to completion at clinical trial organization.
Heema Desai, Texila American University, India
International Conference on Harmonization guideline E6 requires clinical trial sponsors to conduct monitoring oversight to ensure the protection of rights, safety and welfare of the clinical trial subjects. In 1988, the FDA released a guideline for Monitoring Clinical Investigati [....] » Read More
Title : Latest trends in Bio-degradation of Xenobiotics for cleaning up the environment
Neha Agarwal, University of Lucknow, India
The release of Xenobiotics into the environment is a matter of global concern, as the harmful chemicals when reach in the environment; are stable over a prolonged period resulting in their accumulation in the environment. A gargantuan acceleration in the release of xenobioti [....] » Read More
Title : Acetylcholinesterase and ATPases: Targets of biologically active compounds
Mirjana B. Colovic, University of Belgrade, Serbia
Acetylcholinesterase is a serine hydrolase whose key biological role is the termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. The reversible inhibition of brain acetylcholinesterase is the major therapeutic targ [....] » Read More
Title : Understanding the issues with recruitment in pediatric clinical trials in India as cited by key stake holders and to draw down the strategies for better recruitment
Tanvi S Kabre, Texila American University, India
A steep rise is seen in conduct of clinically trials not just globally but in India as well over the years. Through this pharma industry is striving to serve high-quality treatments and procedure options catering to all classes of populations and including those for complex disea [....] » Read More
Title : An insight to anti-acne potentials: In-vitro, ex-vivo and in-vivo models
Deepinder Singh, Chitkara University, India
Acne is the 8th most commonly prevailing chronic skin disorder affecting more than 9.4% population worldwide. Its pervasiveness has been predominant in juveniles especially in males during adolescence. However, acne dominance in females is higher during adulthood. The market toda [....] » Read More
Title : Advanced cancer diagnosis and therapy using carbon nanodots/tetrapyrrolic macrocycles conjugates
Gil Goncalves, University of Aveiro, Portugal
Carbon is one of the most relevant elements on earth to all forms of life and presents a wide range of natural allotropic forms with high economic potential. Inspired by nature, scientists started to design synthetic strategies for the development of novel allotropic carbon nanom [....] » Read More
Title : API characterization – why dissolution testing can help you learn more about Active Ingredient.
Samir Haddouchi, Sotax Pharma Services, France
Dissolution is a critical parameter of pharmaceutical dosage forms. It is indeed an extremely powerful tool to acquire knowledge about pharmaceutical products. The dissolution techniques can also be used to learn more about the properties of the Active Pharmaceutical Ingredient ( [....] » Read More
Title : Chlorine dioxide as root canal irrigation solution in endodontic treatment
Hilal Erdogan, Nevsehir University, Turkey
Root canal treatment applied to inflamed teeth is a dental treatment method that aims to keep the natural tooth in the mouth by fulfilling its functional, phonetic, and aesthetic functions. For this purpose, the removal of all vital or necrotic tissues, microorganisms, and microb [....] » Read More
Title : Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs) and Amino acid esters as novel non-cyclooxygenase inhibitors for colorectal cancer chemoprevention
Tarek Aboul Fadl, Assiut University, Egypt
A structure-based medicinal chemistry strategy was applied to design new NSAID prodrugs that show growth inhibitory activity against human colon tumor cells through cyclooxygenase (COX)-independent mechanism. In vitro testing of the synthesized compounds against the human HT-29 c [....] » Read More
Title : Continuous glucose monitors impact on glycemic control among American Indian and Alaskan Natives: Single center, pre- post- comparison
Alena Korbut, IHS/Cherokee Nation, United States
Introduction: Continuous glucose monitors (CGM) technology provides insight into a complete picture of a person’s blood glucose levels throughout the day and the full effect insulin has on the blood glucose trends. The data generated by CGM can be used to make real-tim [....] » Read More
Title : Formulation and evaluation of Escitalopram loaded bio nanosuspension for brain specificity.
Deepika Raina, Graphic Era Hill University, India
In the United States, it is estimated that depression costs the country over $210 billion each year in lost productivity, health care costs, and absenteeism. It is estimated that between 1 and 3 percent of adults suffer from depression, while about 6 percent suffer from majo [....] » Read More
Title : Medicine waste pollution: A Brazilian view about pharmacopollution and public health
Andre Luiz Pereira, Hemominas Foundation, Brazil
Pharmacopollution is a public health and environmental outcome of some active pharmaceutical ingredients(API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are the pharmaceutical industry, healthcare facilities (e.g., hos [....] » Read More
Title : Understanding ABC transporters to navigate human diseases
Ruchika Bajaj, University of California San Francisco, United States
Membrane proteins constitute 30% of genome in organisms and are involved in numerous physiological processes. ABC transporters is a class of membrane proteins which are ubiquitously present in all organisms, bind and hydrolyze ATP to power the solute transport and are associated [....] » Read More
Title : APE-1 redox activity inhibition impacts dopaminergic system in inflammatory pain condition
Amira Zaky, Alexandria University, Egypt
Apurinic/Apyrimidinic Endonuclease 1/Redox Effector- 1 (APE1/Ref-1) is a negative regulator of inflammatory response via several mechanisms in neuronal cells. APE1’s redox activity stimulates the DNA-binding activity of several transcription factors. We investigated targeti [....] » Read More
Title : Critical issues related to plant and pharmaceutical biotechnologies to achieve nations' development and welfare
Eman A. Alam, Al-Azhar University, Egypt
In recent years, biotechnology has expanded too much in its scope and applicability. Now biotechnology is well known for its great role in the field of medicine and is also used in many other areas such as food and fuel. Via using plant and pharmaceutical biotechnologies, we can [....] » Read More
Title : Development and in-vitro evaluation of K-carrageenan bead for sustained delivery of Repaglinide
Divya Sharma, Delhi Pharmaceutical Sciences and Research University, India
Controlled drug delivery systems release drugs at a pre-set pace in order to maintain a constant drug concentration over a set period of time while minimising side effects. Repaglinide is a low-dose drug that is administered immediately before a meal to lower blood glucose levels [....] » Read More
Title : Method for tailoring diabetes simulator for optimal in silico trial in target populations
Roberto Visentin, University of Padova, Italy
Treatment of type 2 diabetes (T2D) involves a variety of medications, related to the stage of T2D progression. In silico trials can be helpful in this context, speeding up the drug development process and supporting treatment optimization. We recently proposed a T2D simulator (T2 [....] » Read More
Title : Drug Delivery to the Brain using Engineered Protein Capsules (EnPCs®)
Victoria Demina, NEUWAY Pharma GmbH, Germany
The blood brain barrier (BBB) is both a blessing and a curse: On the one hand, the tightly connected endothelial cells covering the cerebral blood vessels protect the brain from harmful large molecules. On the other hand, they are the obstacle to treat severe central nerve system [....] » Read More
Title : Arsenate target specific cell death mechanism in normal and tumoral breast cancer cell lines
Cornelia Braicu, Iuliu Hațieganu University of Medicine and Pharmacy, Romania
Arsenate was demonstrated to be implicated in a wide range of cellular and molecular pathways. These multiple actions of arsenate highlight the need for additional mechanistic studies to determine which actions mediate the diverse biological effects of this compound as an e [....] » Read More
Title : Cardiac myosin inhibitors – New pharmacological approach for obstructive hypertrophic cardiomyopathy treatment
Miroslav Radenkovic, University of Belgrade, Serbia
The modern knowledge of hypertrophic cardiomyopathy (HCM) rapidly evolved over the past twenty years, where the thorough understanding of HCM pathophysiology, combined with innovative therapeutic solutions, finally allowed us to achieve some excellent outcomes, including in obstr [....] » Read More