Acne is the 8th most commonly prevailing chronic skin disorder affecting more than 9.4% population worldwide. Its pervasiveness has been predominant in juveniles especially in males during adolescence. However, acne dominance in females is higher during adulthood. The market today is flooded with the pool of anti-acne medications (allopathic/herbal; oral, topical/systemic) that contain either single therapeutic agent or multi targeted agents acting over multiple pathological factors. Conversely, incidence of bacterial resistance, drug targeting, skin penetrability, toxicity and other pharmaceutical issues limits the clinical applicability of these commercial therapies. Thus, the therapy opted besides considering drug therapeutic and safety profile should take into account patient’s related factors i.e. lesion type and severity, pre-existing medical conditions, patient’s endocrine history and the desired treatment mode. This warrants the extensive understanding and research of skin physiology under normal and diseased condition so that newer, safer and effective medication could be devised. In order to ensure the safety and efficacy of innovative cosmeceuticals/drugs for acne, various acne models are implemented and analyzed. This review is an attempt to provide insight of various acne models and would provide the researcher with the varied evaluation parameters for formulating palliative acne therapies and comparative profiling of test formulation with standard commercial preparations.