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Speaker at Pharma Conferences - Bhupendra Gopalbhai Prajapati
Ganpat University, India
Title : Self microemulsifying systems based topical lipstick of antifungal agent

Abstract:

Self-emulsifying system-based lipstick may prove to have potential of enhancing the moisturizing characteristics and deliver the hydrophobic drug antifungal drugs for the treatment of lip fungal infections. In this study, the self-emulsifying (SEDDs) mixture of Ketoconazole was obtained using Isopropyl myristate (Oil), Tween 80 (surfactant), and combination of Transcutol P and PEG 400 as co-surfactant. The medicinal lipstick was developed from the SEDDs by using waxes such as bees wax, carnauba wax, and lanolin along with cow ghee and castor oil. The lipstick formulations were assessed on the basis of physicochemical features, such as pH, spreadability, softening point, breaking point, content uniformity, and in vitro drug release. Furthermore, several discriminating tests were performed to evaluate the medicinal potential by performing tests such as skin irritation, ageing stability, and antifungal study. The optimized formulation showed exceptional results in physicochemical analysis and ~88% release of drug in 12 hours. The formulations displayed adequate stability for the period of 2 weeks at various conditions such as room temperature and refrigeration (2°C to 8°C) with no signs of irritation in the skin irritation study. The zone of inhibition produced by lipstick formulation was significantly higher as compared to reference standard (Ketoconazole in ethanol) which shows high antifungal activity. It was concluded form the outcomes that SEDDs based lipstick formulation showed a lot of promise as topical antifungal treatment option for lip fungal infections.

Biography:

Dr. Bhupendra Gopalbhai Prajapati is a Professor in the Department of Pharmaceutics at Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He is also acting as Adjunct Professor at Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, 73000, Nakhon Pathom, Thailand. With over 22 years of experience in academia, research, and industry, he specializes in lipid-based formulations, nano/microparticulate drug delivery, and bioavailability enhancement. A recipient of several prestigious awards, including the AICTE Young Teacher Award and Ganpat University's Staff Excellence honors, Dr. Prajapati has published over 320 research/review papers and has contributed to more than 150 book chapters. He actively mentors Ph.D. and PG scholars and serves as editor or section editor for several international publications in pharmaceutical sciences.

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