Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Bhupendra Gopalbhai Prajapati
Ganpat University, India
Title : Self microemulsifying systems based topical lipstick of antifungal agent

Abstract:

Self-emulsifying system-based lipstick may prove to have potential of enhancing the moisturizing characteristics and deliver the hydrophobic drug antifungal drugs for the treatment of lip fungal infections. In this study, the self-emulsifying (SEDDs) mixture of Ketoconazole was obtained using Isopropyl myristate (Oil), Tween 80 (surfactant), and combination of Transcutol P and PEG 400 as co-surfactant. The medicinal lipstick was developed from the SEDDs by using waxes such as bees wax, carnauba wax, and lanolin along with cow ghee and castor oil. The lipstick formulations were assessed on the basis of physicochemical features, such as pH, spreadability, softening point, breaking point, content uniformity, and in vitro drug release. Furthermore, several discriminating tests were performed to evaluate the medicinal potential by performing tests such as skin irritation, ageing stability, and antifungal study. The optimized formulation showed exceptional results in physicochemical analysis and ~88% release of drug in 12 hours. The formulations displayed adequate stability for the period of 2 weeks at various conditions such as room temperature and refrigeration (2°C to 8°C) with no signs of irritation in the skin irritation study. The zone of inhibition produced by lipstick formulation was significantly higher as compared to reference standard (Ketoconazole in ethanol) which shows high antifungal activity. It was concluded form the outcomes that SEDDs based lipstick formulation showed a lot of promise as topical antifungal treatment option for lip fungal infections.

Biography:

Dr.Bhupendra works as Professor in Department of Pharmaceutics, Shree S.K.Patel College of Pharmaceutical Education and Research, Ganpat University, North Gujarat, India. He did his Ph.D. from Hemchandracharya North Gujarat University, Patan. He did his PG and UG from M.S.University, Baroda. He has 19 years of experience in academic/industry (17+2). He awarded with Carrier Award for Young Teacher by AICTE, New Delhi in 2013. He also awarded for Distinguished Associate Professor by in TechNExt India 2017 by CSI, Mumbai. He claims on his name more than fifty national and international publication. He fetched grant for Research Projects, Staff Development Programs, Seminars, Conferences and Travel Grants from National and State Government agencies. He is also given his guidance in few industrial consultancy projects conducted at institute. Currently he is working in the field of lipid-based drug delivery and nanotech formulations. He guided 7 Ph.D. and 45 PG research scholars supervised. 5 Ph.D and 3 PG research scholars are currently working under his guidance in the field of Nanoparticulate Drug Delivery and Bioavailability Enhancement.

Watsapp