Mucoadhesive systems for the fast delivery of drugs

Title : Mucoadhesive systems for the fast delivery of drugs

Abstract:

The necessity of new systems for drug delivery in children and specific procedures is clearly needed, in the case of children the difficulty of the correct dose administration is a problem when the drug carrier is not easy to administrate by a non-specialized adult. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in the oral cavity due to their capacity to release pharmaceutical drugs at a fast and sustained rate.  Electrospun fibers have many characteristics that make them ideal drug carriers for local delivery. Mucoadhesives fibrous systems of poly (vinyl alcohol) and poly (vinyl pyrrolidone) loaded with propranolol and dexamethasone phosphate will be discussed for their potential application in the oral cavity. Physicochemical (SEM, FTIR, TGA, DSC) and biological (MTT assay) characterization will be described in order to present the morphology, chemical composition, and thermal behaviour of the fibrous mats, and cytotoxicity in fibroblast will be visualized, drug delivery rate, mucoadhesive and degradation rate will be also discussed. The evaluated mucoadhesive loaded fibers presented potential characteristics to be used in the oral cavity, where successfully tridimensional fibrous scaffolds were fabricated with an average fiber diameter of about 368 ± 161 nm, thermal stability higher than 250^oC, fibers were degraded completely before 15 min and high mucoadhesive and biocompatibility in fibroblast were observed. All these results give potential characteristics to these systems and promote the continuing evaluation at higher levels such as in animals and clinical studies. Poly (vinyl pyrrolidone) loaded fibers with dexamethasone phosphate are proposed for endodontic procedures avoiding injection of the anti-inflammatory drug and poly (vinyl alcohol) loaded fibers with propranolol for the treatment of hemangiomas in children.

Biography:

Dr. Luis Villarreal is a research professor at the Faculty of Engineering Sciences and Technology, Autonomous University of Baja California, Tijuana, Baja California, Mexico, member of the National System of Researchers SNII-CONAHCyT Level 2, and a member of the academic body Applied Bioengineering "In Consolidation". To date, Dr. Villarreal has published 51 indexed articles, with a total of 1,134 citations in Scopus. Currently, Research and Graduate Coordinator of the Faculty, General Coordinator of MyDAUD-Multicampus. He has participated in more than 70 national and international conferences. Founder and Editor-in-Chief of the Revista de Ciencias Tecnológicas (RECIT) (only 5 official ones at UABC), organizing president of the main international conferences of the Faculty FCITEC and member of the editorial committee of important publishers such as Bentham, MDPI, Hindawi, Wiley. He is a member of the editorial advisory board of the journal “Current Drug Delivery” and a referee for more than 210 articles participating in publishers such as Elsevier, Wiley, Springer, MDPI and Hindawi among others. He also participates as an evaluator of research projects for funding in Mexico, Italy, Malaysia and Peru. He has contributed to the generation of human resources with 10 undergraduate theses, 10 master's theses and 5 doctoral theses. His research lines in the area of Biomaterials are in Tissue Engineering, Drug Release Systems and Biotechnology, among others. The improvement in the treatment of infants is his primary objective.