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Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Keerti Maheshwari
Delhi pharmaceutical sciences research and university, India
Title : Formulation, development and evaluation of chronotherapeutic drug delivery system for the treatment of Nocturnal Asthma


Nocturnal asthma mainly known as nighttime asthma, it is mainly occur during sleep. The mechanism of this is related to the circadian rhythms that may influence mediators and inflammatory cells, cholinergic tone and hormonal changes. Chronotherapeutics is defined as a treatment system where the in vivo drug availability has been timed in accordance to cyclic rhythms of drug-related biological phenomena to create maximum benefit minimizing harm. Salbutamol Sulphate is used drug for the relief from several respiratory system-associated problems such as asthma, bronchitis, apnoea, and other respiratory tract infection. Salbutamol Sulphate may be useful in the treatment of nocturnal asthma. This study is to especially design and evaluate for the Pulsatile drug dosage delivery system and oral site-specific containing Salbutamol Sulphate, which is knowingly targeted the colon in pH time-dependent and to regulate the drug deliver level with the circadian rhythm of nocturnal asthma. In this study, we mainly focus on have attempted to develop chrono pharmaceutical approach using a novel drug dosage form and microsphere dosage form, that drug is taken during night with a programmed start of drug deliver early in the morning time, that could prevent sharp increment in the effective time of asthmatic attacks during the morning time, and time where the asthmatic attack chances are larger. The subsequent idea to design a novel to treat with the high potential benefits by the drug dosage novel drug delivery system. Based on the concept that at the pH of the colon various polymers release the drug due to their solubility at specified pH, a designed pH time-dependent activity pulsatile novel drug delivery dosage system. The main specific objective of this research is to treat the nocturnal symptoms of asthma by the drug delivery system of salbutamol sulphate by exploring the feasibility of time and pH time-dependent activity colon specific, of the chronotherapeutic drug delivery system. A satisfactory conclusion was made to develop new chronotherapeutic microsphere formulation using polymers chitosan and Eudragit S100 and evaluated for In vitro characterization studies.


Keerti Maheshwari has done M. pharma in pharmacology from Jayoti Vidyapeeth women” s university, Jaipur in 2017-19,B.pharma from Jayoti Vidyapeeth women’s university, Jaipur in 2013-17.After that Joined as a Junior technical officer in National institute of pharmaceutical education and research, Raebareli in 2019-2021.After that joined as a JRF in Centre for precision medicine and pharmacy in Delhi pharmaceutical sciences and research university, New delhi.