Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Essa Abdullah Aldulaym
Clinical Pharmacy Student, Saudi Arabia
Title : Antibiotic and phytoconstituent combination loaded gastric floating microsponge for the effective eradication of Helicobacter Pylori infection: Formulation, physicochemical and microbiological assessments

Abstract:

The present investigation aimed to develop an antibiotic and a phytoconstituent combination loaded gastric floating microsponge for the effective eradication of Helicobacter pylori infection by the synergistic effects of the loaded drugs. The microsponge formulations were prepared by quasi-emulsion method, and then the prepared formulations were assessed for various parameters including in vitro drug release study and in vitro anti H. pylori activity. The production yield, drug content, and entrapment efficiency of the microsponges were increased on increasing the polymer and the drugs amounts. All microsponges were exhibited prolonged in vitro floating time (?12 h), and controlled in-vitro drug release (for 24 hours). The surface morphology imaging study revealed that the microsponge was spherical in shape and has a porous surface with interconnecting channels. DSC study demonstrated the absence of drug-drug and drug-polymer interactions. The in vitro MIC results showed that the anti H. pylori activity of the microsponge containing both drugs was showing synergistic and more prolonged effect than the microsponge containing single drugs. Thus, it could be concluded that the loading of two synergistic drugs in a gastric floating microsponge could be an excellent option to effectively eradicate H. pylori infection and the pharmacokinetic and pharmacodynamic assessments of our microsponge formulation can be expected to provide a rewarding outcome.

Biography:

Essa Aldulaym, Clinical pharmacy student, Imam Abdulrahman Bin Faisal University, Entrepreneur of EdTech platform, Part-time Project manager of Founders2Founders company.

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