In the United States, it is estimated that depression costs the country over $210 billion each year in lost productivity, health care costs, and absenteeism. It is estimated that between 1 and 3 percent of adults suffer from depression, while about 6 percent suffer from major depression at some point in their lives. While antidepressants are not universally effective yet, research is revealing important information about their use that may help to limit the limitations of the current treatment approach. In the current research, nanoformulation was formulated with a novel biopolymer. Because of their unique shape, nanoparticles are not usually absorbed by the body on their own. ten formulations were prepared to vary the polymer ratio. The prepared formulation was evaluated for content uniformity, pH, in-vitro drug release Ex-vivo, and stability. The results revealed that the (1: 1) ratio was the best formulation on the basis of the response obtained.