Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Divya Sharma
Delhi Pharmaceutical Sciences and Research University, India
Title : Development and in-vitro evaluation of K-carrageenan bead for sustained delivery of Repaglinide


Controlled drug delivery systems release drugs at a pre-set pace in order to maintain a constant drug concentration over a set period of time while minimising side effects. Repaglinide is a low-dose drug that is administered immediately before a meal to lower blood glucose levels by releasing insulin from pancreas, which acts on the cells. Since repaglinide is totally passed by bile, it is a healthy substitute for diabetic patients along impaired kidney function. To retain therapeutic concentrations of repaglinide in blood plasma and reduce side effects such like hypoglycaemia, kappa (κ)- carrageenan beads were used to establish a regulated and long-lasting drug delivery system. Drugs and enzymes, trapped using κ-carrageenan like a trapping medium. The Inotropic gelatin method is used to make micro beads. Optimized drug release formulation in vitro was tested in hydrochloric acid (0.1N) and phosphate buffer pH 7.4 using dissolution test apparatus. To learn drug release rate and process, in vitro data was fitted to zero and first order, Korsmeyer-Peppas and Higuchi models. Repaglinide adopted a method for controlling the release of microbead release control system, according to the Korsmeyer-Peppas model. This method eliminates the possibility of an alkaline microenvironment, which was previously created by using gastro-retentive drug delivery systems.


Divya Sharma has passed her M. Pharma from Kurukshetra University, Haryana, India. She has been awarded with a gold medal for having 1st Rank in her postgraduate programme. After that she joined Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India for pursuing her career in academic field where she has been appointed as an Assistant Professor. She has published research, review paper, book chapter in the various multidisciplinary fields. She also had a patent that too related to the nano-formulation called phytosome. Right now, she is pursuing her PhD from Delhi Pharmaceutical Sciences and Research University, New Delhi, India.