Speaker at Pharmaceutics and Drug Delivery Systems 2021 - Esmaiel Jabbari
University of South Carolina, United States
Title : Drug Delivery to Stem Cells in Regenerative Medicine


Translation of nanoscale discoveries from the laboratory to the clinic promises new diagnostic tools, drug targeting modalities, gene therapy platforms, and tissue constructs for patients. Tissue morphogenesis during fetal development is highly dependent on spatial and temporal expression of multiple morphogens targeting different progenitor cells. During fetal development, mesenchymal stem cells (MSCs) and endothelial colony forming cells (ECFCs) are implicated in bone formation coupled by paracrine signalling between the two progenitor cells. The invading ECFCs secrete osteogenic morphogens (BMP2) to stimulate cell differentiation and mineralization whereas the differentiating MSCs release vasculogenic morphogens (VEGF) to further stimulate capillary formation for the metabolically active osteoblasts. I will present in my seminar novel drug delivery strategies and tissue models for timed and localized release of morphogens using self-assembled nanogels in a micro-patterned co-culture system to stimulate paracrine signalling and coupling osteogenesis to vasculogenesis.


Esmaiel Jabbari is Tenured Professor of Chemical and Biomedical Engineering at University of South Carolina. Prof. Jabbari’s laboratory specializes in the creation of multi-cellular tissue models for skeletal tissue engineering and cancer drug delivery. He received Berton Rahn Award in 2012 from AO Foundation and Stephen Milam Award in 2008 from Oral and Maxillofacial Surgery Foundation. He was elected to the College of Fellows of American Institute for Medical and Biological Engineering in 2013. Prof. Jabbari has authored >250 articles and presented >100 invited lectures. He serves as the Academic Editor for PLOS ONE and Associate Editor of Gels.