The full PDDS 2018 scientific program across 3 days — keynotes, oral presentations, and posters. Talks are ordered by program prominence within each day.
Day 1
- Keynote
Next generation of drug delivery system: Stimuli-sensitive combination nanopreparations
Vladimir P. Torchilin · Northeastern University, United States
Tumor therapy, especially in the case of multidrug resistant cancers, could be significantly enhanced by using siRNA down-regulating the production of proteins, which are involved in cancer cell resistance, such as Pgp…
- Keynote
Drug screening and targeting against the stem subpopulation of cancer cells
Esmaiel Jabbari · University of South Carolina, United States
A major contributing factor to mortality in cancer patients is relapse after therapy, and developing resistance. Cancer recurrence and resistance is related to the existence of a very small population of initiating stem…
- Keynote
Targeting nanomedicine to the vascular endothelium
Vladimir Muzykantov · University of Pennsylvania the Perelman School of Medicine, United States
Endothelial cells lining the vascular lumen represent an important therapeutic target in many dangerous maladies. Some of them have no effective pharmacotherapy, at least in part due to inadequate drug delivery to…
- Keynote
Nanoparticle delivery of mitochondria-associated microRNA regulating inflammation in the central nervous system
Joe E. Springer · University of Kentucky, United States
Traumatic brain injury (TBI) is a leading cause of long-term impairments in higher cognitive function. Ongoing destructive secondary injury events occur minutes to days after the initial insult characterized by a…
- Keynote
Signaling peptides for brain diseases: Delivery and action
Eugenia V Gurevich · Vanderbilt University, United States
Arrestins were discovered as the key proteins responsible for the shutoff of the G protein-dependent signaling by G protein-coupled receptors (GPCRs). Later it was discovered that arrestins regulate multiple signaling…
- Oral · In-Person
Understanding the Impact of nanoparticle structure on cellular response
Georgina Kate Such · The University of Melbourne, Australia
Nanoparticle delivery systems have potential for biomedical applications due to the ability of the nanoparticles to better target diseased cells or tissue, and therefore optimise the therapeutic payload to a treatment…
- Oral · In-Person
Overcoming the barriers to effective targeted drug delivery through stem cell-derived nano-ghosts
Marcelle Machluf · Technion – Israel Institute of Technology, Israel
Targeted drug and gene delivery technologies, mostly for oncological applications, have been extensively investigated for more than three decades. With only seven passively-targeted systems and just two…
- Oral · In-Person
Chimeric and multicompartment drug delivery systems: Lessons learned and future perspectives
Natassa Pippa · University of Athens, Greece
The aim of this investigation is to present the novel progress performed in recent years in the field of design and development of new nanocarriers used in pharmaceutical nanotechnology. Special attention is assigned to…
- Oral · In-Person
Delivery of siRNA in vivo to the liver using redox sensitive and ionizable lipids
Daniel Zucker · NOF Europe GmbH, Germany
A lipid nanoparticle (LNP) composed of a series of disulfide bridge cleavable and pH-reponsive lipid-like materials (COATOSOME SS-E-P4C2) was developed as a platform of a gene delivery system. The LNP showed good…
- Oral · In-Person
Getting health allies from agriculture enemies: Plant viruses as smart nanoparticles for vaccine/drug delivery
Selene Baschieri · Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Italy
Plant virus nanoparticles (pVNPs) might represent an ideal delivery tool in terms of biocompatibility and biodegradability. They have evolved to use plants as their reproductive hosts, and to this aim, have developed…
- Oral · In-Person
The influence of gut microbiota-mediated bile acid metabolism on the cellular response to therapeutics at the intestinal barrier
Elaine Frances Enright · University College Cork, Israel
Once regarded obscure, the cohabitation of man and microbe has gained increasing recognition as a determinant of the health status of the host. To date, pharmacokinetic research at the host-microbe interface has been…
- Oral · In-Person
Cyclodextrin-based photoactive liposomal nanoparticles for tumor targeting
Ilya Yakavets · Universite de Lorraine, France
Application of meta-tetra(hydroxyphenyl)chorin (mTHPC), one of the most potent photosensitizer (PS), in the photodynamic therapy (PDT) of solid tumors encounters several complications resulting from its insolubility in…
- Oral · In-Person
?rabinogalactan and Glycyrrhizic acid as promising agents for oral drug delivery
Mikhail V. Khvostov · N.N. Vorozhtsov Institute of Organic Chemistry SB RAS, Russian Federation
Oral drug delivery is the most popular route because of the low expenses and long-term compliance. However, this introduction route has several limitations for drug molecules. Some of them are low water solubility and…
- Oral · In-Person
Polyethylenimine-based nanoparticles decorated with small molecules mimicking RGD peptide for targeted plasmid DNA delivery
Ali Dehshahri · Shiraz University of Medical Sciences, Iran (Islamic Republic of)
Targeted delivery of polymer-based nanoparticles has been considered as an efficient approach to transfer genetic materials into cells. Considering the over expression of integrin αVβ3 receptor on tumor cells and the…
Day 2
- Keynote
Physicochemical characterization of co-crystals and cyclodextrin inclusion complexes of bioactive molecules
Mino R. Caira · University of Cape Town, South Africa
Significant reduction or elimination of unfavourable properties of both well-established drugs and new drug candidates (e.g. poor aqueous solubility, thermal instability, hygroscopicity) can often be achieved via…
- Keynote
Peptide Delivery to the brain: A novel treatment for migraine
Gillian Hutcheon · Liverpool John Moores University, United Kingdom
Migraine is an extremely common, disabling condition which ruins the lives of millions of patients worldwide and is hard to treat effectively. Existing migraine medications are only partially effective, they have…
- Oral · In-Person
Lipid based parenteral depots for biomolecules, an update on recent work
Gerhard Winter · LMU Munchen, Germany
A wide range of new data on recent work with solid and semisolid lipid based depot formulations will be presented. As an alternative to PLGA based implants, lipid based rods for long term delivery of protein drugs have…
- Oral · In-Person
The effects of drug encapsulation into gellan gum matrix by the example of roxithromycin, naproxen and meloxicam Tomasz Osmalek
Tomasz Osmalek · Poznan University of Medical Sciences (PUMS), Poland
Gellan gum is a linear, anionic biopolymer produced by the bacteria Sphingomonas elodea . Its chain consists of a tetrasaccharide repeating unit of L-rhamnose, D-glucose and D-glucuronate. Due to the unique structure…
- Oral · In-Person
5-Tiered (pre-) formulation approach to support toxicology studies
Marc Du Jardin · Janssen, Belgium
The Beerse developability groups provides physchem and formulation support to both discovery and toxicology teams within Janssen Belgium. In early discovery, it is essential to keep pace with the discovery teams and…
- Oral · In-Person
Porous biodegradable particles for efficient transfollicular drug delivery
Yulia Svenskaya · Saratov State University, Russian Federation
Porous calcium carbonate submicron particles are proposed as effective carriers for transdermal drug transportation. Administration of bioactive substances via skin appendages arouses a scientific interest regarding to…
- Oral · In-Person
Novel RNA-carbohydrate conjugates for modulation of LDLR and cholesterol by transcriptional silencing
Kira Astakhova · University of Southern Denmark, Denmark
The Low Density Lipoprotein receptor (LDLR) is a cell surface expressed protein that binds and internalizes low density lipoprotein (LDL), resulting in cholesterol being made available to the cell. A method to stably…
- Oral · In-Person
Myometrium-targeted liposomes for prevention of preterm labor
Biana Godin · Houston Methodist Research Institute, United States
Preterm labor, leading to preterm birth (birth prior to 37 weeks of pregnancy) is a leading cause of perinatal morbidity and mortality affecting estimated 15 million births worldwide annually. Since the fetus is not yet…
- Oral · In-Person
Poly (vinyl pyrrolidone) nanofibers as drug delivery of sildenafil citrate
Luis Jesus Villarreal Gomez · Universidad Autónoma de Baja California, Mexico
Pulmonary arterial hypertension (PAH) is one of the main risk factors for cardiovascular, cerebrovascular and heart failure diseases, which are important causes of mortality in Mexico. In just six years, between 2000…
- Oral · In-Person
The reversal of type 2 diabetes - The role of the Bile acids
Gerald H Tomkin · Beacon Hospital and Trinity College Dublin, Ireland
Type 2 diabetes is a complex disorder. A relative rather than an absolute lack of insulin allows blood sugar to rise above normal even though the patients secret excess insulin. This is termed insulin resistance and is…
- Oral · In-Person
New potential nanotechnology-based therapy with novel Gal-3 inhibitor for the treatment of rheumatoid arthritis
Nataliya Storozhylova · University of Santiago de Compostela, Spain
Intra-articular (IA) administration of drugs is an appealing therapy for the effective treatment of joint diseases; however, challenging due to premature elimination of injected drugs and drug delivery systems (DDSs)…
- Oral · In-Person
New aerosol treatment for human nasal cavity through numerical simulation
Hadrien Calmet · Barcelona Supercomputing Center (BSC-CNS), Spain
New treatment in aerosol medicine exhalation through the nose (ETN) is one of promising and comprehensive methods for Eosinophilic Chronic Rhinosinusitis (ECRS) with asthma. The patient inhales aerosol of inhaled…
- Oral · In-Person
Numerical evaluation of exhalation through the nose treatment for eosinophilic chronic Rhinosinusitis using computational fluid dynamics
Takahisa yamamoto · National Institute of Technology, Gifu College, Japan
Recently patients who suffer Eosinophilic Chronic Rhinosinusitis with asthma (ECRS) have significantly increased in Asia. This disease has been recognized as an incurable disease, and its symptoms are multiple nasal…
- Oral · In-Person
Case presentation: Patient with metastatic pancreatic adenocarcinoma treated with nanoliposomal irinotecan combination therapy
Matej Dobravc Verbic · University Medical Centre Ljubljana, Slovenia
Pancreatic cancer is the fourth most fatal cancer in both men and women. Patients usually remain asymptomatic until advanced stages of disease, and prognosis has not improved over the past 20 years. However, new…
- Oral · In-Person
Nanostructured biomaterials and technologies for bone regeneration
Marcelo Nacucchio · University of Buenos Aires, Argentina
New scaffolds and biomaterials will be presented with pharmaceutical characterization as well biological evaluation. For one bioceramic/polymeric new product clinical trials results will be presented. Prospectives…
- Oral · In-Person
Brain targeted nanotherapeutics: An enticing journey from ideation to product realization Vandana B Patravale
Vandana B. Patravale · Institute of Chemical Technology, India
Dementia (neurodegenerative ailments) accounts for over 50 million cases worldwide with estimated new 7.7 million cases every year. Neurodegenerative ailments associated progressive decline in clinical condition mainly…
- Oral · In-Person
Investigations on the cytotoxic effect of gold nanoparticles synthesized using Ferulic acid on human epidermoid carcinoma (A431) cells
Lonchin Suguna · Central Leather Research Institute, India
Nowadays, gold nanoparticles (AuNPs) are gaining wide attention in several areas including research and development and medical fields. Certain polyphenols have the property of converting the Au 3+ solution into AuNPs…
- Workshop
Challenges of in vitro drug release testing in case of advanced mucosal formulations
Mario Jug · University of Zagreb, Croatia (Hrvatska)
Mucosal route of drug delivery is recognised as suitable alternative to conventional drug administration routes (i.e. oral and parenteral), providing the possibility of more efficient local therapy with reduced systemic…
- Poster · In-Person
Discovering multiple drug binding sites and modes with Wrap ‘n’ Shake
Monika Eniko Balint · University of Pecs, Hungary
Blind docking has been widely used for fast mapping of binding sites on the entire surface of drug targets. Reliability of blind docking is limited by approximations of hydration models, simplified handling of molecular…
- Poster · In-Person
Thermoresponsive nanocarriers for doxorubicin delivery combined with hyperthermia
Ilya Yakavets · Universite de Lorraine, France
Due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, superparamagnetic iron oxide (SPIO) nanoparticles (NPs) can be used as multimodal cancer therapy…
- Poster · In-Person
In vivo siRNA delivery in whitefish: siRNA uptake and the efficacy of gene expression silencing
Pawel Brzuzan · University of Warmia and Mazury in Olsztyn, Poland
The delivery of therapeutic snippets of RNA (mainly siRNA) to the right cells at the right time is an essential step in the RNA mediated therapeutics, that in fish has not been studied in sufficient detail. Here we…
- Poster · In-Person
Unnatural amino acids derived peptidomimetics with potent anti-biofilm activity
Jeong Kyu Bang · Korea Basic Science Institute, Korea, Republic of
We present on the first chemical synthesis of ultra-short pyrazole-arginine based antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl-pyrazole amino acids. Through systematic tuning of…
- Poster · In-Person
Poly(glycolide-?-caprolactone) and poly(glycolide-?-caprolactone-D,L-lactide) coatings enriched with ciprofloxacin formed on metallic implants
Joanna Jaworska · Polish Academy of Sciences, Poland
Caprolactone-based polymers are willingly used as a biodegradable materials with desirable properties. They are frequently used as a drug delivery systems for controlled release of different active substances like…
- Poster · In-Person
Dual-targeted biodegradable micelles for anticancer drug delivery
Katarzyna Jelonek · Polish Academy of Sciences, Poland
Polymeric micelles have been widely studied and developed as drug carrier for targeting solid tumors. They are able to incorporate drugs of poor water solubility in the hydrophobic core while the hydrophilic corona…
- Poster · In-Person
PLGA nanoparticles co-delivering MDR1 and BCL2 siRNA for overcoming resistance of paclitaxel and cisplatin in recurrent or advanced ovarian cancer
Hyung Jun Ahn · Korea Institute of Sceince and Technology, Korea, Republic of
The inherent or acquired resistance to paclitaxel and cisplatin, which are commonly used chemotherapeutic agents for ovarian cancer treatment, remains an important issue in chemotherapy of multidrug resistant ovarian…
- Poster · In-Person
Non-invasive method for screening drug penetration in skin using different dermal drug delivery systems by Raman microscopy
Attila Gacsi · University of Szeged, Hungary
Dermal drug delivery systems are getting more attention nowadays because their application is beneficial in many conditions. Dermal application is advantageous due to a decrease in potential adverse reactions and the…
- Poster · In-Person
Eucommia ulmoides ameliorates glucotoxicity by suppressing advanced glycation endproducts in diabetic mice kidney
Sang Keun Ha · Korea Food Research Institute, Korea, Republic of
In this study, we evaluated the effects of EU on AGEs-induced renal disease and explored the possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice received EU extract…
- Poster · In-Person
Study of penetration and analgesic and antiinflamatory effects of indomethacin nanoemulsion
Anayanti Arianto · University of Sumatera Utara, Indonesia
Background: Indomethacin is a potential nonsteroidal anti-inflammatory drugs (NSIDs), but it can cause gastrointestinal irritation if it is given orally. The delivery system of indomethacin through skin can avoid the…
- Poster · In-Person
Quality evaluation of rifaximin tablets by an eco-friendly spectrophotometric method in the ultraviolet region
Ana Carolina Kogawa · Univ Estadual Paulista – UNESP, Brazil
Rifaximin, an oral antimicrobial, acts locally in the gastrointestinal tract with minimal systemic adverse effects. It is mainly used for the treatment of hepatic encephalopathy, but also in cases of ulcerative colitis…
- Poster · In-Person
Radiolabeled drug/ligand loaded Micelles: Exploring diagnostic and therapeutic potentials for glioma through the intranasal route
Prashant G. Upadhaya · Institute of Chemical Technology, India
Developing effective methods for drug delivery into the brain is one of the major challenges faced today. In the current arena the research fraternity is mostly involved in the drug discovery and chemical modification…
- Poster · In-Person
The most sensitive neurodevelopmental period for the effects of methamphetamine on creating predisposition to drug addiction in adulthood
Ivana Hrebickova · Charles University, Czech Republic
Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. Prenatal/neonatal MA exposure (5 mg/ml/kg) during gestation…
Day 3
- Keynote
Impact of inhalation manoeuvre parameters on drug delivery to the Lungs from dry powder inhalers in-vitro and Ex-vivo
El Hassane Larhrib · University of Huddersfield, United Kingdom
Inhaled therapy plays an important role in the management of airway diseases such as, asthma and chronic obstructive pulmonary disease (COPD). Peak inhalation flow has been considered for so many years by the inhalation…
- Keynote
Flexible analyses of population-based pharmaco-epidemiological studies of comparative effectiveness and safety of drugs
Michal Abrahamowicz · McGill University, Canada
Recent large governmental initiatives e.g. Canadian Drug Safety and Effectiveness Network or the US Sentinel program, emphasize the need to assess the real-life effectiveness and safety of drugs in populationbased…
- Oral · In-Person
HEA-HEMA hydrogels: Composition effect on physicochemical and pharmaceutical properties
Irina Ermolina · De Montfort University School of Pharmacy, United Kingdom
Hydrogels have attracted considerable attention due to their capability to be used for numerous pharmaceutical and biomedical applications (i.e. drug delivery systems, contact lenses and wound dressings). Hydrogels are…
- Oral · In-Person
Cyclic GMP-AMP: A new hope for metabolic disease?
Chaodong Wu · Texas A&M University, United States
Obesity is an ongoing pandemic which serves a causal factor of a wide range of metabolic diseases such as type 2 diabetes, non-alcoholic fatty liver disease, and atherosclerotic cardiovascular diseases. Accumulating…
- Oral · In-Person
Computational blind docking of ligands to drug targets: Methodology and applications
Csaba Heteny · University of Pecs, Hungary
Originally, computational blind docking (BD) was introduced as a fast approach for finding binding positions and conformations of ligand molecules via scanning the entire surface of target molecules. BD can find not…
- Oral · In-Person
The competitive binding studies of CMP inhibitor and polysialic acid (polySia) to the polybasic polysialyltransferase domain (PSTD) in the polysialyltransferase
Guo-Ping Zhou · Guangxi Academy of Sciences, China
Polysialic acid (polySia) is a novel glycan that posttranslationally modifies neural cell adhesion molecules (NCAMs) in mammalian cells. Up-regulation of polySia-NCAM expression is associated with tumor progression in…
- Oral · In-Person
The main trends in the developing novel therapeutics for alzheimer’s disease treatment
Sergey Bachurin · Russian Academy of Sciences, Russian Federation
Alzheimer’s disease (AD) is characterized by a chronic and progressive neurodegenerative process resulting from the intracellular and extracellular accumulation of fibrillary proteins: beta-amyloid and…
- Oral · In-Person
Casein-based nanovehicles for oral delivery of chemotherapeutic combinations to overcome multidrug resistance in gastric cancer
Maya Bar-Zeev · Technion – Israel Institute of Technology, Israel
Gastrointestinal cancers are the third leading cause of cancer-related deaths worldwide. Moreover, multidrug resistance (MDR) mediated by ATP-dependent efflux transporters remains a dominant obstacle toward curative…
- Oral · In-Person
Use of an inflating agent to engineer novel lactose carrier for inhalation and drug deposition in-vitro using three model drugs: Salbutamol, beclomethasone and fluticasone
Ursula Thevarajah · University of Huddersfield, United Kingdom
The aim of this study was to engineer a novel lactose carrier in the presence of an inflating agent in the crystallisation medium to produce large hollow spherical carrier particles for inhalation. Hollow spherical…
- Oral · In-Person
Characterization of lactose carrier for dry powder inhaler formulations
Faiza Naseer · University of Huddersfield, United Kingdom
Most dry powder inhalers are formulated by mixing micronized drugs with lactose as a carrier. Lactose is the major element in terms of weights in a dry powder inhaler formulation therefore, any changes in its…
- Oral · In-Person
EAAT3 proteins as a pharmacological target for the design of new antiepileptic drugs
Lourdes Amable Vega Rasgado · Escuela Nacional de Ciencias Biologicas del Instituto Politecnico Nacional, Mexico
people suffer from epilepsy, and 30% of them do not respond with traditional antiepileptic drugs. Thus, different strategies for seizures control in such patients are required. Seizures are the result of an imbalance…
- Oral · In-Person
Hard alginate capsules shell as enteric capsules
Hakim Bangun · University of Sumatera Utara, Indonesia
Most pharmaceutical capsules are made from gelatine. These material dissolve in the low pH gastric juices in the stomach. But, for certain purposes capsules are designed to pass through the stomach and into the…
- Oral · In-Person
Synthesis and cytotoxicity studies on novel piperazinylacetamides
Enise Ece Gurdal · Yeditepe University, Turkey
Cancer, characterized by uncontrolled cell growth, causes the death of about 7 million patients each year. Malignant cells can spread all over the body through the lymphatic and the circulatory systems. Side effects of…
- Oral · In-Person
Stability studies on the formulations of inclusion complex of tenoxicam in SBE7 ? cyclodextrin and beta cyclodextrin
K.V.R.N.S.Ramesh · RAK Medical & Health Sciences University, United Arab Emirates
The present study was carried out to evaluate the usefulness of sulfobutyl ether β-cyclodextrin (SBE7-β-CD), [captisol], in increasing the dissolution rate of tenoxicam. The efficacy of captisol in increasing the…
- Oral · In-Person
Development and evaluation of self micro emulsifying drug delivery systems of itraconazole
Hemant K. S. Yadav · RAK Medical & Health Science University, United Arab Emirates
During the presentation the presenter will be talking about the formulation and evaluation of self microemulsifying system of a poorly water soluble drug. The talk will include what are self microemulsifying systems and…
- Oral · In-Person
Microbiological pharmaceutical analysis: Better safe than sorry
Ana Carolina Kogawa · Univ Estadual Paulista – UNESP, Brazil
Rifaximin, an oral antimicrobial, is mainly used for the treatment of hepatic encephalopathy, but also in cases of ulcerative colitis, irritable bowel syndrome, Clostridium difficile, travelers' diarrhea and acute…
- Oral · In-Person
Nature of naproxen enantiomers medicinal activity difference. Study by using model systems and modern physical methods.
Tatyana V. Leshina · Voevodsky Institute of Chemichal Kinetics and Combustion SB RAS, Russian Federation
The difference in the medical properties of the enantiomers of many chiral drugs is a well-known fact. This is a big problem, since most drugs are still used in the form of racemates. The latter is connected with the…
- Oral · In-Person
Nanoparticles in receptor-mediated drug delivery to brain parenchyma
Mehrdad Azarmi Aghajan · Shahid Beheshti University, Iran (Islamic Republic of)
In RMT route, NPs are designed to target specific cells and cause cell death or induce a significant change in cellular behavior. Receptor?targeted therapeutics are developed to restrict the distribution of toxic drugs…
- Oral · In-Person
Methotrexate induced liver and renal toxicity management by cornus mas: Back to nature antioxidants in fighting drug side effects
Hassan Saeiahan · Iran University of Medical science, Iran (Islamic Republic of)
Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antineoplastic, antimetabolite and antifulate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the…
Present your research at PDDS 2027
Abstract submissions for the 2027 program are open · September 13–15, 2027 · Olympia Hotel, Events & Spa, Valencia, Spain.
Join the PDDS 2027 delegation
Valencia · September 13–15, 2027 · Hybrid · in-person & virtual
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