A wide range of new data on recent work with solid and semisolid lipid based depot formulations will be presented. As an alternative to PLGA based implants, lipid based rods for long term delivery of protein drugs have been studied in detail. The depot systems consist only of bio [....] » Read More
Gellan gum is a linear, anionic biopolymer produced by the bacteria Sphingomonas elodea. Its chain consists of a tetrasaccharide repeating unit of L-rhamnose, D-glucose and D-glucuronate. Due to the unique structure and beneficial properties, gellan is broadly described as a [....] » Read More
The Beerse developability groups provides physchem and formulation support to both discovery and toxicology teams within Janssen Belgium. In early discovery, it is essential to keep pace with the discovery teams and assure timely delivery of solubility results using Semi High Thr [....] » Read More
Porous calcium carbonate submicron particles are proposed as effective carriers for transdermal drug transportation. Administration of bioactive substances via skin appendages arouses a scientific interest regarding to reduced systemic toxicity in terms of targeted delivery. A dr [....] » Read More
The Low Density Lipoprotein receptor (LDLR) is a cell surface expressed protein that binds and internalizes low density lipoprotein (LDL), resulting in cholesterol being made available to the cell. A method to stably over-express LDLR could result in an increased removal of LDL f [....] » Read More
Preterm labor, leading to preterm birth (birth prior to 37 weeks of pregnancy) is a leading cause of perinatal morbidity and mortality affecting estimated 15 million births worldwide annually. Since the fetus is not yet fully developed before 37 weeks of pregnancy, health problem [....] » Read More
Pulmonary arterial hypertension (PAH) is one of the main risk factors for cardiovascular, cerebrovascular and heart failure diseases, which are important causes of mortality in Mexico. In just six years, between 2000 and 2006, HBP prevalence increased 19.7% to one in three Mexica [....] » Read More
Type 2 diabetes is a complex disorder. A relative rather than an absolute lack of insulin allows blood sugar to rise above normal even though the patients secret excess insulin. This is termed insulin resistance and is preceded by a hyperinsulinaemia phase where blood sugar [....] » Read More
Intra-articular (IA) administration of drugs is an appealing therapy for the effective treatment of joint diseases; however, challenging due to premature elimination of injected drugs and drug delivery systems (DDSs) from the synovial cavity. Aiming at increased retention and [....] » Read More
New treatment in aerosol medicine exhalation through the nose (ETN) is one of promising and comprehensive methods for Eosinophilic Chronic Rhinosinusitis (ECRS) with asthma. The patient inhales aerosol of inhaled corticosteroid (ICS) medicine from mouth using portable inhaler. Th [....] » Read More
Recently patients who suffer Eosinophilic Chronic Rhinosinusitis with asthma (ECRS) have significantly increased in Asia. This disease has been recognized as an incurable disease, and its symptoms are multiple nasal polyps, excessive rhinorrhea, rhinostenosis and asthma. The diff [....] » Read More
Pancreatic cancer is the fourth most fatal cancer in both men and women. Patients usually remain asymptomatic until advanced stages of disease, and prognosis has not improved over the past 20 years. However, new treatment options for locally advanced and metastatic disease have e [....] » Read More
New scaffolds and biomaterials will be presented with pharmaceutical characterization as well biological evaluation. For one bioceramic/polymeric new product clinical trials results will be presented. Prospectives technologies associated with this field of bone regeneration will [....] » Read More
Dementia (neurodegenerative ailments) accounts for over 50 million cases worldwide with estimated new 7.7 million cases every year. Neurodegenerative ailments associated progressive decline in clinical condition mainly results from poor transport of therapeutic actives across blo [....] » Read More
Nowadays, gold nanoparticles (AuNPs) are gaining wide attention in several areas including research and development and medical fields. Certain polyphenols have the property of converting the Au3+ solution into AuNPs at an appropriate pH and at the same time binding to them. [....] » Read More
Significant reduction or elimination of unfavourable properties of both well-established drugs and new drug candidates (e.g. poor aqueous solubility, thermal instability, hygroscopicity) can often be achieved via relatively simple strategies such as co-crystallization with partne [....] » Read More
Migraine is an extremely common, disabling condition which ruins the lives of millions of patients worldwide and is hard to treat effectively. Existing migraine medications are only partially effective, they have unwanted side effects and some patients are resistant to any curren [....] » Read More
Blind docking has been widely used for fast mapping of binding sites on the entire surface of drug targets. Reliability of blind docking is limited by approximations of hydration models, simplified handling of molecular flexibility, and imperfect search algorithms. Wrap and [....] » Read More
Due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, superparamagnetic iron oxide (SPIO) nanoparticles (NPs) can be used as multimodal cancer therapy agent by combining chemotherapy and hyperthermia. Fe3O4 nanop [....] » Read More
The delivery of therapeutic snippets of RNA (mainly siRNA) to the right cells at the right time is an essential step in the RNA mediated therapeutics, that in fish has not been studied in sufficient detail. Here we report an efficient in vivo delivery of MiRNA92b-3p mimic to whit [....] » Read More
We present on the first chemical synthesis of ultra-short pyrazole-arginine based antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl-pyrazole amino acids. Through systematic tuning of hydrophobicity, charge, and peptide length, we can obtain the shortes [....] » Read More
Caprolactone-based polymers are willingly used as a biodegradable materials with desirable properties. They are frequently used as a drug delivery systems for controlled release of different active substances like: antibiotics, growth factors, and hormones. They are mostly copoly [....] » Read More
Polymeric micelles have been widely studied and developed as drug carrier for targeting solid tumors. They are able to incorporate drugs of poor water solubility in the hydrophobic core while the hydrophilic corona provides biocompatibility and prolonged circulation in blood afte [....] » Read More
The inherent or acquired resistance to paclitaxel and cisplatin, which are commonly used chemotherapeutic agents for ovarian cancer treatment, remains an important issue in chemotherapy of multidrug resistant ovarian cancer. Currently, it is still challenging to deal with the rec [....] » Read More
Dermal drug delivery systems are getting more attention nowadays because their application is beneficial in many conditions. Dermal application is advantageous due to a decrease in potential adverse reactions and the avoidance of first pass metabolism. However, the skin penetrati [....] » Read More
In this study, we evaluated the effects of EU on AGEs-induced renal disease and explored the possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice received EU extract (200 mg/kg) orally for 6 weeks. EU treatment did not change [....] » Read More
Background: Indomethacin is a potential nonsteroidal anti-inflammatory drugs (NSIDs), but it can cause gastrointestinal irritation if it is given orally. The delivery system of indomethacin through skin can avoid the side effect, but the skin has a major barrier that is stra [....] » Read More
Rifaximin, an oral antimicrobial, acts locally in the gastrointestinal tract with minimal systemic adverse effects. It is mainly used for the treatment of hepatic encephalopathy, but also in cases of ulcerative colitis, irritable bowel syndrome, travelers' diarrhea and acute [....] » Read More
Developing effective methods for drug delivery into the brain is one of the major challenges faced today. In the current arena the research fraternity is mostly involved in the drug discovery and chemical modification of pre-existing molecules which certainly do not facilitate en [....] » Read More
Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. Prenatal/neonatal MA exposure (5 mg/ml/kg) during gestation and/or lactation makes adult rats more sensitive to acute inject [....] » Read More
Mucosal route of drug delivery is recognised as suitable alternative to conventional drug administration routes (i.e. oral and parenteral), providing the possibility of more efficient local therapy with reduced systemic drug exposure as well as alternative application route for d [....] » Read More
Hydrogels have attracted considerable attention due to their capability to be used for numerous pharmaceutical and biomedical applications (i.e. drug delivery systems, contact lenses and wound dressings). Hydrogels are swellable polymeric materias capable of imbibing a large amou [....] » Read More
Obesity is an ongoing pandemic which serves a causal factor of a wide range of metabolic diseases such as type 2 diabetes, non-alcoholic fatty liver disease, and atherosclerotic cardiovascular diseases. Accumulating evidence has suggested inflammation as a factor underlying the p [....] » Read More
Originally, computational blind docking (BD) was introduced as a fast approach for finding binding positions and conformations of ligand molecules via scanning the entire surface of target molecules. BD can find not only primary binding sites but also allosteric or prerequisite o [....] » Read More
Polysialic acid (polySia) is a novel glycan that posttranslationally modifies neural cell adhesion molecules (NCAMs) in mammalian cells. Up-regulation of polySia-NCAM expression is associated with tumor progression in many metastatic cancers. Both members of the ST8Sia family of [....] » Read More
Alzheimer’s disease (AD) is characterized by a chronic and progressive neurodegenerative process resulting from the intracellular and extracellular accumulation of fibrillary proteins: beta-amyloid and hyperphosphorylated Tau. Over accumulation of these aggregates leads to [....] » Read More
Gastrointestinal cancers are the third leading cause of cancer-related deaths worldwide. Moreover, multidrug resistance (MDR) mediated by ATP-dependent efflux transporters remains a dominant obstacle toward curative cancer therapy. Furthermore, most chemotherapeutic agents are li [....] » Read More
The aim of this study was to engineer a novel lactose carrier in the presence of an inflating agent in the crystallisation medium to produce large hollow spherical carrier particles for inhalation. Hollow spherical Engineered carrier and tomahawk shaped commercial carrier (contro [....] » Read More
Most dry powder inhalers are formulated by mixing micronized drugs with lactose as a carrier. Lactose is the major element in terms of weights in a dry powder inhaler formulation therefore, any changes in its physicochemical properties can affect drug detachment from the surface [....] » Read More
people suffer from epilepsy, and 30% of them do not respond with traditional antiepileptic drugs. Thus, different strategies for seizures control in such patients are required. Seizures are the result of an imbalance between excitatory and inhibitory impulses on the central nervo [....] » Read More
Most pharmaceutical capsules are made from gelatine. These material dissolve in the low pH gastric juices in the stomach. But, for certain purposes capsules are designed to pass through the stomach and into the intestine before dissolving, such products are described [....] » Read More
Cancer, characterized by uncontrolled cell growth, causes the death of about 7 million patients each year. Malignant cells can spread all over the body through the lymphatic and the circulatory systems. Side effects of chemotherapeutic drugs being used for cancer treatment affect [....] » Read More
The present study was carried out to evaluate the usefulness of sulfobutyl ether β-cyclodextrin (SBE7-β-CD), [captisol], in increasing the dissolution rate of tenoxicam. The efficacy of captisol in increasing the dissolution when compared with beta cyc [....] » Read More
During the presentation the presenter will be talking about the formulation and evaluation of self microemulsifying system of a poorly water soluble drug. The talk will include what are self microemulsifying systems and how to prepare them along with their advantages. Approaches [....] » Read More
Rifaximin, an oral antimicrobial, is mainly used for the treatment of hepatic encephalopathy, but also in cases of ulcerative colitis, irritable bowel syndrome, Clostridium difficile, travelers' diarrhea and acute diarrhea. Rifaximin does not present microbiological methods d [....] » Read More
The difference in the medical properties of the enantiomers of many chiral drugs is a well-known fact. This is a big problem, since most drugs are still used in the form of racemates. The latter is connected with the difficulties of separation. One of the most prominent represent [....] » Read More
In RMT route, NPs are designed to target specific cells and cause cell death or induce a significant change in cellular behavior. Receptor?targeted therapeutics are developed to restrict the distribution of toxic drugs to only the pathologic cells, thus diminishing collateral sid [....] » Read More
Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antineoplastic, antimetabolite and antifulate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Disturbances in the normal redox stat [....] » Read More
Inhaled therapy plays an important role in the management of airway diseases such as, asthma and chronic obstructive pulmonary disease (COPD). Peak inhalation flow has been considered for so many years by the inhalation scientists as the most important parameter governing drug de [....] » Read More
Recent large governmental initiatives e.g. Canadian Drug Safety and Effectiveness Network or the US Sentinel program, emphasize the need to assess the real-life effectiveness and safety of drugs in populationbased studies. Increasing availability of large databases, generated thr [....] » Read More
Title : Understanding the Impact of nanoparticle structure on cellular response
Georgina Kate Such, The University of Melbourne, Australia
Nanoparticle delivery systems have potential for biomedical applications due to the ability of the nanoparticles to better target diseased cells or tissue, and therefore optimise the therapeutic payload to a treatment site. Self- assembled polymeric carriers have generated partic [....] » Read More
Title : Overcoming the barriers to effective targeted drug delivery through stem cell-derived nano-ghosts
Marcelle Machluf, Technion – Israel Institute of Technology, Israel
Targeted drug and gene delivery technologies, mostly for oncological applications, have been extensively investigated for more than three decades. With only seven passively-targeted systems and just two actively-targeted antibody-drug conjugates in oncological use, it seems, howe [....] » Read More
Title : Chimeric and multicompartment drug delivery systems: Lessons learned and future perspectives
Natassa Pippa, University of Athens, Greece
The aim of this investigation is to present the novel progress performed in recent years in the field of design and development of new nanocarriers used in pharmaceutical nanotechnology. Special attention is assigned to chimeric and multicompartment drug delivery systems. Chimeri [....] » Read More
Title : Delivery of siRNA in vivo to the liver using redox sensitive and ionizable lipids
Daniel Zucker, NOF Europe GmbH, Germany
A lipid nanoparticle (LNP) composed of a series of disulfide bridge cleavable and pH-reponsive lipid-like materials (COATOSOME SS-E-P4C2) was developed as a platform of a gene delivery system. The LNP showed good stability in the serum. The tertiary amine and disulfide bridge of [....] » Read More
Title : Getting health allies from agriculture enemies: Plant viruses as smart nanoparticles for vaccine/drug delivery
Selene Baschieri, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Italy
Plant virus nanoparticles (pVNPs) might represent an ideal delivery tool in terms of biocompatibility and biodegradability. They have evolved to use plants as their reproductive hosts, and to this aim, have developed infection strategies very different from those adopted by their [....] » Read More
Title : The influence of gut microbiota-mediated bile acid metabolism on the cellular response to therapeutics at the intestinal barrier
Elaine Frances Enright, University College Cork, Israel
Once regarded obscure, the cohabitation of man and microbe has gained increasing recognition as a determinant of the health status of the host. To date, pharmacokinetic research at the host-microbe interface has been primarily directed towards effects on metabolism. Microbial bil [....] » Read More
Title : Cyclodextrin-based photoactive liposomal nanoparticles for tumor targeting
Ilya Yakavets, Universite de Lorraine, France
Application of meta-tetra(hydroxyphenyl)chorin (mTHPC), one of the most potent photosensitizer (PS), in the photodynamic therapy (PDT) of solid tumors encounters several complications resulting from its insolubility in aqueous medium. It requires low light doses and concentration [....] » Read More
Title : ?rabinogalactan and Glycyrrhizic acid as promising agents for oral drug delivery
Mikhail V. Khvostov, N.N. Vorozhtsov Institute of Organic Chemistry SB RAS, Russian Federation
Oral drug delivery is the most popular route because of the low expenses and long-term compliance. However, this introduction route has several limitations for drug molecules. Some of them are low water solubility and poor bioavailability. To overcome these limitations “hos [....] » Read More
Title : Polyethylenimine-based nanoparticles decorated with small molecules mimicking RGD peptide for targeted plasmid DNA delivery
Ali Dehshahri, Shiraz University of Medical Sciences, Iran (Islamic Republic of)
Targeted delivery of polymer-based nanoparticles has been considered as an efficient approach to transfer genetic materials into cells. Considering the over expression of integrin αVβ3 receptor on tumor cells and the presence of the binding site for tetraiodothyroaceti [....] » Read More
Title : Next generation of drug delivery system: Stimuli-sensitive combination nanopreparations
Vladimir P. Torchilin, Northeastern University, United States
Tumor therapy, especially in the case of multidrug resistant cancers, could be significantly enhanced by using siRNA down-regulating the production of proteins, which are involved in cancer cell resistance, such as Pgp or survivin. Even better response could be achieved is such s [....] » Read More
Title : Drug screening and targeting against the stem subpopulation of cancer cells
Esmaiel Jabbari, University of South Carolina, United States
A major contributing factor to mortality in cancer patients is relapse after therapy, and developing resistance. Cancer recurrence and resistance is related to the existence of a very small population of initiating stem cells (CSCs) in the tumor tissue with high expression of ATP [....] » Read More
Title : Targeting nanomedicine to the vascular endothelium
Vladimir Muzykantov, University of Pennsylvania the Perelman School of Medicine, United States
Endothelial cells lining the vascular lumen represent an important therapeutic target in many dangerous maladies. Some of them have no effective pharmacotherapy, at least in part due to inadequate drug delivery to intended site of action. Coupling drugs and carriers with specific [....] » Read More
Title : Nanoparticle delivery of mitochondria-associated microRNA regulating inflammation in the central nervous system
Joe E. Springer, University of Kentucky, United States
Traumatic brain injury (TBI) is a leading cause of long-term impairments in higher cognitive function. Ongoing destructive secondary injury events occur minutes to days after the initial insult characterized by a cascade of pervasive biochemical and pathophysiological stressors i [....] » Read More
Title : Signaling peptides for brain diseases: Delivery and action
Eugenia V Gurevich, Vanderbilt University, United States
Arrestins were discovered as the key proteins responsible for the shutoff of the G protein-dependent signaling by G protein-coupled receptors (GPCRs). Later it was discovered that arrestins regulate multiple signaling pathways, including mitogen activated protein (MAP) kinase pat [....] » Read More