Speaker at Global Conference on Pharmaceutics and Drug Delivery Systems 2018 - Ana Carolina Kogawa
Univ Estadual Paulista – UNESP, Brazil
Title : Quality evaluation of rifaximin tablets by an eco-friendly spectrophotometric method in the ultraviolet region

Abstract:

Rifaximin, an oral antimicrobial, acts locally in the gastrointestinal tract with minimal systemic adverse effects. It is mainly used for the treatment of hepatic encephalopathy, but also in cases of ulcerative colitis, irritable bowel syndrome, travelers' diarrhea and acute diarrhea. Rifaximin tablets do not present an ecologically correct method by spectrophotometry in the ultraviolet region neither in official compendiums nor in literature. The analytical techniques for determination of rifaximin reported in the literature require large amount of time to release results and are significantly onerous. Furthermore, they use toxic reagents both for the operator and environment and, therefore, can not be considered environmentally friendly analytical techniques. The objective of this work was to develop and validate an eco-friendly spectrophotometric method in the ultraviolet region to quantify rifaximin in tablets. The method was validated by linearity, selectivity, precision, accuracy and robustness. It was linear over the concentration range of 10-30 mg mL-1 with correlation coefficients greater than 0.9999 and limits of detection and quantification of 1.39 and 4.22 mg mL-1, respectively. The validated method is useful and applied for the routine quality control of rifaximin in tablets, since it is effective, low cost and fast in the release of results, it optimizes analysts and equipment and uses environmentally friendly solvents. The quality of a pharmaceutical product is directly related to the health of patients and a practical analysis method and reliable can be the first step in the rational use of pharmaceuticals. In this context, universities have executed a fundamental role serving as research centers for the development and validation of analytical methods.

Audience take away:

  • The audience will take away from my presentation a useful and applied method for the routine quality control of rifaximin tablets.
  • It showed linearity, selectivity, accuracy, precision, robustness and adequate detection and quantification limits in the range 10 to 30 µg mL-1.
  • The developed and validated method is effective, fast in the release of results, low cost, it optimizes analysts and equipment, uses environmentally friendly solvents, being considered a green method, which does not prejudice either the operator or the environment.
  • The quality of a pharmaceutical product is directly related to the health of patients and a practical analysis method and accurate can be the first step in the rational use of pharmaceuticals.

Biography:

Ana Carolina Kogawa graduated in Pharmacy-Biochemistry (2008), Master (2012) and PhD in Pharmaceutical Sciences (2015) from “Universidade Estadual Paulista – UNESP” (Brazil). She has experience in managing people, lectures, quality tools and pharmaceuticals activities of industry with emphasis on Quality Control. Currently she conducts a project financed by Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp) with the drug rifaximin for the development of her Postdoctoral research at the School of Pharmaceutical Sciences of Araraquara, Brazil.

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