Speaker at Global Conference on Pharmaceutics and Drug Delivery Systems 2018 - Sang Keun Ha
Korea Food Research Institute, Korea, Republic of
Title : Eucommia ulmoides ameliorates glucotoxicity by suppressing advanced glycation endproducts in diabetic mice kidney

Abstract:

In this study, we evaluated the effects of EU on AGEs-induced renal disease and explored the possible underlying mechanisms using streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice received EU extract (200 mg/kg) orally for 6 weeks. EU treatment did not change blood glucose and glycated hemoglobin (HbA1c) levels in diabetic mice. However, the EU-treated group showed a significant increase in the protein expression and activity of glyoxalase 1 (Glo1), which detoxifies the AGE precursor, methylglyoxal (MGO). EU significantly upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) expression but downregulated that of receptor for AGE (RAGE). Furthermore, histological and immunohistochemical analyses of kidney tissue showed that EU reduced periodic acid–Schiff (PAS)-positive staining, AGEs, and MGO accumulation in diabetic mice.

Audience take away:

  • Pharmacuticals, glucotoxicity; advanced glycation end-product

Biography:

Korea Food Research Institute, 2011-present.

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