Biography:
Prof. Brzuzan leads a team that focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology.The team has skills in using both experimental fish (whitefish, rainbow trout) and cell cultures to study perturbations of molecular responses to environmental pollutants. His present interest is in disease states featuring microRNA in drug induced liver toxicity as well as current understanding of microRNAsas therapeutic targets in cancer. He looks also if bioactive cyanobacterial metabolites have molecular abilities to modulate regulatory elements of cell processes (RNA, protein), thus becoming important tools for clarifying the mechanisms of these cell processes and serving as lead structures for the development of new therapeutic agents.
Title : In vivo siRNA delivery in whitefish: siRNA uptake and the efficacy of gene expression silencing