Speaker at Global Conference on Pharmaceutics and Drug Delivery Systems 2018 - Irina Ermolina
De Montfort University School of Pharmacy, United Kingdom
Title : HEA-HEMA hydrogels: Composition effect on physicochemical and pharmaceutical properties

Abstract:

Hydrogels have attracted considerable attention due to their capability to be used for numerous pharmaceutical and biomedical applications (i.e. drug delivery systems, contact lenses and wound dressings). Hydrogels are swellable polymeric materias capable of imbibing a large amount of liquid and, therefore, a large amount of drug. Recently we have described novel cross-linked 2-hydroxyethylacrylate-co-2-hydroxyethylmethacrylate (HEA-HEMA) hydrogels with different co-polymer compositions synthesized by three-dimensional free-radical copolymerisation. The aim of the present work is to characterize the physicochemical and pharmaceutical properties of HEA-HEMA hydrogels, which potentially can be used as sustain drug delivery systems. The effects of the hydrogel composition (HEA/HEMA ratios) and  liquid medium (aqueous PEG and glycerol solutions) on morphology, swelling and mechanical properties were examined using different analytical techniques. The molecular dynamics results for hydrogels were obtained by Broadband Dielectric Spectroscopy. The current study has been specifically focused on the analysis of the free/bound water redistribution in the hydrogels using thermoanalytical techniques. Also the effect of different methods of sterilization was studied with respect to the stability of hydrogels. The pramaceutical aspect of this study included the analysis of drug loading and release for the cases of low molecular weigth drugs (riboflavin) and proteins (lysozyme).  The results show that HEA-HEMA hydrogels can be used as a sustain drug delivery system for both small drugs and biomacromolecules. The variation of the HEA-HEMA composition as well as liquid medium permits controlling the properties of hydrogels allowing producing the hydrogels with the drug release rate desired.

Biography:

Irina Ermolina gained her PhD degree in 1995 in molecular physics at Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, following by postdoctoral studies at Hebrew University of Jerusalem, Glasgow University and Southhampton University. Currently, she is a senior lecturer at De Montfort University, Leicester, UK, teaching the pharmaceutical technology, pharmaceutical material sciences and analytical techniques. Dr Ermolina specializes in pharmaceutical and biopharmaceutical materials science; drug delivery systems (hydrogels and nanoparticles); PAT; formulation development and stability study of freeze-dried pharmaceuticals; dynamic structure of proteins in solutions and membrane films. She has published 49 peer reviewed articles.

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