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Speaker at Global Conference on Pharmaceutics and Drug Delivery Systems 2018 - Hakim Bangun,
University of Sumatera Utara, Indonesia
Title : Hard alginate capsules shell as enteric capsules


Most pharmaceutical capsules are made from  gelatine. These material dissolve in the low pH gastric juices in the stomach. But, for certain purposes capsules are designed to pass through the stomach and into the intestine before dissolving,  such products are described by a variety of terms, including gastric resistant, entero soluble,  delayed release, and enteric capsules. Enteric capsules are used when the drug may irritate the gastric mucosa. Enteric capsules also used when the drug is  inactivated by gastric fluid (such as stomach acid). 
    In this sesion  it will be discussed about the hard alginate capsule shell.  Hard alginate capsules are  made from sodium alginate.  Sodium alginate is a sodium salt of alginic acid. Alginic acid  is a polysaccharide that is derived from seaweed (brown algae) and it is non-toxic, biodegradable, and biocompatible. 
       The preparation, physical properties, and the application of hard alginate capsules shell as enteric capsules. The physical properties of hard alginate capsules shell  such gastric resistance in vitro and in vivo, disintegration in vitro, britleness, equilibrium moisture content, water vapour permeability, and drug release will be discussed. Furthermore,  drug biovailability and the safety to the stomach in animal experiment will be also discussed. As drugs model are used that drugs are irritating the gastric mucosa, namely nonsteroidal antiinflamatory drugs (aspirin, indomethacin, mefenamic acid) and FeSO4 antianemic drug.  


Hakim Bangun obtained Ph.D. degree from Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan on 1990. Since 1980 he has been working as academic staf at Faculty of Pharmacy, University of Sumatera Utara. He became Professor of Pharmaceutical Technolog/Physical Pharmacy on 1999. His research interest is about the application of alginate in pharmaceutical preparation, such as enteric capsules, gastroretentive drug delivery system, drug encapsulation, gastric delivery system, sustained release, nano capsules, peridental gel etc. He also interests about the biological activities of alginate.