The full PDDS 2024 scientific program across 3 days — keynotes, oral presentations, and posters. Talks are ordered by program prominence within each day.
Day 1
- Oral · In-Person
Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up via biodesign, bio- and chemical engineering, translational applications, and upgraded business modeling to secure the human healthcare and biosafety
Sergey Suchkov · N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, InMedStar and Biona, Russian Federation
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular…
- Oral · In-Person
Pharmacokinetic properties of TNX-102 SL, a sublingual formulation of cyclobenzaprine hydrochloride
Bruce Daugherty · Tonix Pharmaceuticals, United States
TNX-102 SL is a sublingual formulation for cyclobenzaprine (CBP) hydrochloride (HCl) designed for bedtime dosing that is being developed for fibromyalgia (FM) via improvement in sleep quality. TNX-102 SL is a eutectic…
- Oral · In-Person
Mannitol as eutectic forming agent for improved sublingual delivery of Cyclobenzaprine HCl
Marino Nebuloni · University of Insubria, Italy
In solid drug product formulation, the knowledge of possible interactions between the drug substance and the excipients is a crucial point for the prediction of chemical and physical stability. Often, an excipient(s)…
- Oral
Clinical decision making in advanced and metastatic breast cancer cases between PARP inhibitors and CDK4/6 inhibitors
Priya Hays · Hays Documentation Specialists, LLC, United States
Background: PARP inhibitors and CDK 4/6 inhibitors have been studied extensively as model targeted agents for advanced and metastatic breast cancer with hormone receptor positive/HER2 negative molecular subtype, the…
- Oral
Gastrointestinal performance simulation system for the analysis of eltrombopag formulations
Stella Kafkala · Genepharm Pharmaceutical Company, Greece
Eltrombopag olamine is the active substance of the innovator product Revolade, which is indicated for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and acquired severe aplastic anemia…
- Oral
Microemulsion based in situ gel of Erythromycin for Ocular Ailments
Dasharath Muljibhai Patel · Gujarat Technological University, India
Background: Conventional preparation of erythromycin ointment is available in the market as an ocular formulation. Ointment dosage form is linked to many side effects, including transient blurred vision, irritation and…
- Oral
Preparation and characterization of inhaled luteolin nano-liposomes for the potential management of pulmonary arterial hypertension
Fatma Haddad · University of Bradford, United Kingdom
Luteolin is a natural flavonoid abundant in several fruits, vegetables, and medicinal herbs. Although luteolin has numerous pharmacological activities, its low water solubility and bioavailability restrict its…
- Oral
Supercritical microfluidic system for production of nanoparticles and liposomes for pharmaceutical formulation
Yusuke Shimoyama · Tokyo Institute of Technology, Japan
Pharmaceutical formulation techniques have been developed as achieving controlled-release system and high bioavailability of active pharmaceutical ingredients (APIs). Formation of the pharmaceutical suspension with…
- Oral
The promise of nanotechnology in personalized & precision medicine: Drug discovery & development being partnered with nanotechnologies via the revolution at the nanoscale
Sergey Suchkov · N D Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, InMedStar and Biona, Russian Federation
A new systems approach to subclinical, predictive and/or diseased states and wellness resulted in a new Hi Tech trend in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, despite…
- Oral
Development and evaluation of prolonged-release dutasteride transdermal delivery system
Shereen M Assaf · Jordan University of Science and Technology, Jordan
Benign prostatic hyperplasia (BPH), an enlargement of the prostate affecting older men, leads to urinary complications. Oral administration of Dutasteride (DTS) is a common treatment, but it poses challenges for the…
- Oral
Potential bruton tyrosine kinase (BTK) inhibitors determined by virtual screening, molecular docking, and molecular dynamics simulation studies
Alper Onder · Canakkale Onsekiz Mart University, Turkey
Bruton tyrosine kinase (BTK) is a downstream mediator of the B cell receptor (BCR) signalling pathway and affects B cell proliferation and differentiation. Evidence showing BTK expression in the majority of…
- Oral
In silico, synthesis, and in vitro studies of novel FOXM1 Inhibitors for targeted triple negative breast cancer therapy
Ferah Comert Onder · Canakkale Onsekiz Mart University, Turkey
Triple-negative breast cancer (TNBC) is subtype of breast cancer is known for aggressive, leading to early relapses, metastasis and poor clinical prognosis. Significant heterogeneity and drug resistant phenotype and…
- Oral
Design and assessment of transdermal delivery system containing Levodopa-Loaded Nanoparticles
Shereen M Assaf · Jordan University of Science and Technology, Jordan
Levodopa, an essential precursor of dopamine, was widely used to address motor disorders in the early stages of Parkinson's disease. However, its effectiveness was hindered by a short plasma half-life, enzymatic…
Day 2
- Keynote · Virtual
The importance of invitro discriminatory tests in the development of a sublingual dosage form of TNX102 SL(Cyclobenzaprine HCl) tablets
Siobhan Fogarty · Tonix Pharma Limited, Ireland
The formulation of cyclobenzaprine HCl contained in TNX-102 SL has been designed specifically for sublingual administration. Earlier clinical studies indicated that the addition of a basifying agent was necessary for…
- Keynote · Virtual
Pharmaceutical continuous manufacturing: The interaction between different units and tablet properties
Riyadh Al Asady · University of Sheffield, United Kingdom
In a multi-processes pharmaceutical continuous tablet production line such as ConsiGmaTM -25, the quality of the final tablet is a function of different processes and formulation parameters of different units. The…
- Keynote · Virtual
Lipid media with supercritical CO2 for promoted formation of itraconazole cocrystals
Yuna Tatsumi · Tokyo Institute of Technology, Japan
Pharmaceutical cocrystal is one of the crystal engineering techniques to improve the solubility and bioavailability of active pharmaceutical ingredients (APIs). Cocrystal is a crystal composed of API and other molecules…
- Keynote · Virtual
Gastrointestinal performance simulation system for the analysis of eltrombopag formulations
Savvopoulos Pantelis · Genepharm Pharmaceutical Company, Greece
Eltrombopag olamine is the active substance of the innovator product Revolade, which is indicated for the treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP) and acquired severe aplastic anemia…
- Keynote · Virtual
An updated review on the central mechanism of action of paracetamol: Experimental evidence and potential clinical impact
Rassa Pegahi · UPSA, France
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic…
- Keynote · Virtual
Paeoniflorin effectively inhibit melanoma growth through induce senescence and ER stress converging on the Calpain1/ERK5/P21 axis
Shu Chun Liu · Show Chwan Memorial Hospital, Taiwan
Background: Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Paeoniflorin (PAE) is a monoterpene isolated from Traditional Chinese Medicine (TCM) Paeonia Alba, which has been…
- Keynote · Virtual
Polymeric-based formulation for intelligent drug delivery
Mutaz S Salem · Jordan University of Science and Technology, Jordan
Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site.…
- Oral · In-Person
Emerging formulation and delivery applications of vitamin E TPGS
Andreas M Papas · Antares Health Products, United States
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug…
- Oral · In-Person
Drug design for the development of long-acting injectables
Thomas Ullrich · Novartis Biomedical Research, Switzerland
Long-acting injectable (LAI) medications represent the combination of a powerful drug substance and an injectable drug formulation that guarantees that the affected tissue is consistently exposed to the active molecule…
- Oral · In-Person
Clinical pharmacology of aprocitentan (an endothelin receptor antagonist) – The most recent quality progress in treatment of resistant hypertension
Miroslav Radenkovic · University of Belgrade, Serbia
Hypertension is a common condition characterized by persistently high blood pressure (140/90 mmHg or higher). Lowering high blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes…
- Oral · In-Person
Crystallographic in pharmaceutical filed: new frontiers
Maria Cristina Gamberini · University of Modena and Reggio Emilia, Italy
Most commonly produced and marketed drugs are formulated with the pharmacologically active ingredient in solid form (crystalline or amorphous). The solid form is carefully chosen for its characteristics, to increase the…
- Oral
An updated review on the central mechanism of action of paracetamol (Acetaminophen): Experimental evidence and potential clinical impact
Rassa Pegahi · UPSA, France
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic…
- Oral
Innovations in DNA and RNA vaccine technology their impact on treatment efficacy and delivery
Fatemeh Ahmadvand · University of the Genova, Italy
Advances in genetic engineering vaccines have made DNA vaccines a highly promising option for hereditary and acquired illnesses. The main obstacle; nevertheless, is the absence of an ideal delivery system, which…
- Oral
Hybrid compounds: A useful strategy to overcome limited pharmaceutical profile
Barbara De Filippis · University of Chieti, Italy
Hybrid compounds are artificial scaffolds made of two or more pharmacophores that are jointed or overlapped in a single chemical entity. The strategy of combining two different and independently acting compounds into…
- Oral
An enteric capsule for oral drug delivery made from natural materials
Anders B Christensen · Apillet, Denmark
Apillet has developed a unique Oral drug delivery concept (APIVault) which enable targeted release in the intestine of Sensitive (bio)pharmaceuticals, Probiotics and Nutraceuticals. Such compounds are prone to…
- Oral
Development of a sensitive method for the determination of enrofloxacin in falsified veterinary products
Ibrahim A Al Othaim · Saudi Food & Drug Authority, Saudi Arabia
Background: Enrofloxacin (enro) is a broad-spectrum fluoroquinolone antibiotic active against both Gram-positive and Gram-negative bacteria. It is used extensively in both animals and humans due to its high…
Day 3
- Keynote
Why we need to advance from data focus to knowledge focus for managing healthcare transformation?
Bernd Blobel · University of Regensburg, Germany
Health and social care systems around the globe currently undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status…
- Keynote
Unveiling the binding interactions of selected antimalarial drugs with major plasma transporter
Saad Tayyab · UCSI University, Malaysia
Using a variety of spectroscopic methods and in silico analysis, the binding interactions between three antimalarial medications, mefloquine (MEF), lumefantrine (LUM), and pyrimethamine (PYR) and the primary plasma…
- Keynote
Photodegradation of two pharmaceutical namely levofloxacin and atorvastatin via Chitosan/Ag/TiO2 3D printed scaffold
Delia Teresa Sponza · Dokuz Eylul University, Turkey
Pharmaceuticals are highly persistent towards hydrolysis, adsorption, biodegradation, and abiotic degradation .As a result, such pharmaceutical compounds are not effectively removed during sewage treatment. Furthermore…
- Keynote
Liver biopsy handling of metabolic-associated fatty liver disease (MAFLD): The children's hospital of eastern ontario grossing protocol
Consolato M Sergi · University of Alberta, Canada
Introduction: Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients…
- Keynote
Perillyl alcohol (NEO100), a monoterpene with versatile applications for cancer therapy
Axel H Schonthal · University of Southern California, United States
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of…
- Keynote
Preparation and characterization of fibers crafted from PCL/PVP-ChAgG, coupled with investigating their suitability as wound dressings.
Luis Jesus Villarreal Gomez · Universidad Autónoma de Baja California, Mexico
Wound dressings play a pivotal role in wound care by cleansing, shielding, and covering wounds, thereby influencing healing duration, cost-effectiveness, and patient comfort. Electrospun fibers emerge as a promising…
- Keynote
Hydrogen sulfide and substance P: Novel mediators and therapeutic targets for acute pancreatitis
Madhav Bhatia · University of Otago, New Zealand
Acute pancreatitis is a common clinical condition, for which there is no satisfactory treatment available at this time. Excessive systemic inflammatory response syndrome (SIRS) in acute pancreatitis leads to distant…
- Keynote
Integrating QbD for the solubility amelioration of ivacaftor loaded solid lipid nanoparticles in-vitro & in-vivo
Bhupendra Gopalbhai Prajapati · Parul University, India
The present investigation is focused on the application of the Quality by Design (QbD) approach for the development and optimization of SLN formulation of Ivacaftor (IVF). IVF SLN was formulated with the help of…
- Keynote · In-Person
Structural scheme of an electro magneto elastic actuator for nanomedical research
Afonin S.M · National Research University of Electronic Technology, Russian Federation
An electro magneto elastic actuator is electro magneto mechanical device intended for actuation of mechanisms, systems based on the piezoelectric, electrostriction, piezomagnetic, magnetostriction effects, converts…
- Poster
Computational modelling for enhanced drug delivery in drug-coated balloon treatment
Elisabetta Stretti · University of Patras, Greece
Drug-coated balloon (DCB) treatment has recently emerged as an effective non-stent-based strategy for the treatment of atherosclerotic arteries in peripheral artery disease (PAD). DCBs are designed to dilate into the…
- Poster
Impact of implementation of antimicrobial stewardship (AMSP) and infection prevention and measures (IPC) on MDRO profiles in a tertiary care hospital of India
Raja Chakraverty · Indian Council of Medical Research, India
The study was conducted to gather information to assess the extent of impact of antimicrobial stewardship (AMSP) practices on antimicrobial prescribing patterns and bacterial resistance profiles among indoor patients…
- Poster
Unveiling green chemistry: Exploring sustainable practices
Pratip kashinath chaskar · D Y Patil University School of Pharmacy Navi Mumbai, India
The forthcoming presentation will delve into the fundamental tenets of Green Chemistry, highlighting key methodologies such as Phase Transfer Catalysis (PTC), Ionic Liquids (IL), Sonochemistry, and Microwave Irradiation…
- Poster
Comparison of in vitro drug dissolution profiles: Current state and examination of etravirine tablets
Ayse Nur Oktay · University of Health Sciences-Gulhane Faculty of Pharmacy, Turkey
In vitro drug dissolution is a laboratory test of drug tablets to assess product quality. The test measures drug release (i.e. drug dissolution) from tablets. There are numerous scenarios during drug development, as…
- Poster
Design and development of controlled release systems: Versatility in drug formulation
Natassa Pippa · University of Athens, Greece
Controlled-release drug delivery systems exhibit a gamut of benefits, including improved therapeutic efficacy, reduced side effects, improved patient compliance, and optimized medicine use. For this reason, there is…
- Poster
Structure elucidation of drug targets through homology modeling in the AI era
Muhammed Tilahun Muhammed · Suleyman Demirel University, Turkey
Target/Structure-based drug design needs the presence of the target structure to move forward in the drug discovery process. However, the number of macromolecule structures available in the available data banks is…
- Poster
Mesenchymal stromal cells as therapeutic tools in immune disorders: Promising evidence from in vitro results
Panagiotis Mallis · Biomedical Research Foundation Academy of Athens, Greece
Background: Mesenchymal Stromal Cells (MSCs), a multipotent stem cell population which can efficiently be obtained from different tissue sources, exert key specific regenerative and immunomodulatory properties. However…
- Poster
Novel 2, 5-disubstituted oxadiazole scaffolds act as potential antitumour and antibacterial agents
Asish Bhaumik · School of Pharmaceutical Science, India
Introdution: 1, 3, 4-oxadiazole is a five membered heterocyclic aromatic compound containing two nitrogen atom at position three and four and one oxygen atom present at position one. 1, 3, 4 oxadiazole is thermally…
- Poster
Role of natural polymers in drug delivery system
Dharmendra Kumar · Swami Vivekanand Subharti University, India
In recent years, various types of natural polymers have gained prominence in drug delivery systems due to their biocompatibility, biodegradability, and ease of modification. Recent research has further enhanced the…
- Poster
Synthetic antimicrobial peptides as potent therapeutic agents
Deepika Sharma · CGC Mohali Punjab, India
Among the fungal genera, members of the genus Candida are most common causal organisms of human infections. In recent years, increasing drug resistance in fungal pathogenic strains specifically, clinical strains require…
- Poster
UPLC method development and validation for the estimation of sulbactam and durlobactum in pharmaceutical dosage form
Rayhan Shahid Shanavas · Oakridge International School, India
Infectious diseases especially associated with multidrug resistant pathogens in critically ill patients is an area of global research and concern for healthcare professionals across both private and public sector.…
- Poster
PCSK9 roles beyond cholesterol lowering
Maria Borrell · Sant Pau Research Institute, Spain
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase…
- Poster
Human papillomavirus vaccines and impact on decreasing of infection the population
Merita Kucuku · Freelance consultant, Albania
Human Papillomavirus (HPV) vaccines are vaccines used for vaccination against human papillomavirus infection. HPV vaccines prevent infection from different types of human papillomavirus which cause risk for cervical…
- Poster
A novel method of active medication delivery via microneedles using a belousov-zhabotinsky oscillating hydrogel
Shripriya Kalbhavi · Lynbrook High School, United States
Despite the widespread use of hypodermic needles in intradermal medication delivery, they remain a source of pain and trauma in patients young and old. The research introduces a novel approach to active medication…
- Poster
Health risks associated with exposure to organic sunscreens during pregnancy
Anna W Sobanska · Medical University of Lodz, Poland
Pregnant women are exposed to a variety of environmental pollutants – pesticides, drugs, substances of abuse or cosmetic raw materials that enter the body of a mother-to-be by a variety of routes - oral (with…
- Poster
Breakthrough, fast, precise and inexpensive 3D bioprinting of organoids and blood vessels
Vyacheslav R Shulunov · Institute of Physical Materials Science of the Siberian Branch of the Russian Academy of Science, Russian Federation
The calculated specifications of Roll Porous Scaffold (RPS) are orders of magnitude superior to all currently dominant 3D bioprinters in speed, volume, and print density without the use of expensive equipment and…
- Poster
AI-guided spectroscopy and recombinant DNA technologies to discover the new lantibiotics and phytobiotics against multi-drug-resistant infections
Asit Kumar Chakraborty · Vidyasagar University, India
MDR-bacteria causes sepsis and death in patients due to their power to inactivate antibiotics like ampicillin, cefotaxime, tetracycline, streptomycin, chloramphenicol, erythromycin and ciprofloxacin. The mdr genes (amp…
- Poster
Telomere length, inflammatory markers and oxidative stress in pre-eclamptic women
Preeti Sharma · Autonomous State Government Medical College, India
Introduction: Preeclampsia(PE) is pregnancy related syndrome which is mainly by gestational hypertension with proteinuria. it affects 2 to 10 % of pregnant women. Improper maternal spiral artery remodelling leads to…
- Poster
Novel chromogenic method as a sensitive technique in estimating analytes
Khagga Bhavyasri · Osmania University, India
To develop and validate a simple and sensitive UV spectrophotometric method for Quantification of Hesperidin in bulk and Ayurveda formulation including plant extracts using chromogenic compound Gibb’s reagent (2…
- Poster
Preparation and evaluation of herbosome of herbal plant of Lawsonia inermis L. for topical application
Rudra Pratap Singh Rajput · Royal College of Pharmacy, India
Background: Lawsonia inermis L. (Lawsone) was reported to contain carbohydrates, proteins, flavonoids and phenolic compounds, alkaloids, terpenoids. The plant has also been reported to have hepatoprotective…
- Poster
Targeted downregulation of VEGF-A to inhibit angiogenesis in psoriasis using CRISPR/Cas9 complexed lipopolymeric nanoplexes
Abhay Tharmatt · BITS Pilani, India
Psoriasis, an incurable chronic inflammatory skin disease, is characterised by enhanced angiogenesis, abnormal keratinocyte differentiation, and immune cell invasion. Angiogenesis, a critical factor in endothelial cell…
- Poster
The impact of climate change on medicinal plant availability and efficacy
Ali Yetgin · Institute of Nature and Applied Sciences, Department of Biotechnology, Adana, Turkey, Turkey
Medicinal plants have been fundamental in both traditional and modern medicine, offering a wide array of bioactive compounds crucial for therapeutic purposes. The escalating impact of climate change presents notable…
- Poster
Natural plant-based extract-mediated cell death induction potential in human cancer cells -in vitro and in silico strategies for drug development
Suresh P.K · VIT University, India
Extracts from plant sources have been mined for their anti-cancer potential. The n-butanolic extract of the leaves of A.muricata exhibited a higher cytotoxic potential in MDA-MB-435s & HaCaT cells in comparison with…
- Poster
Pharmaceuticals in the Environment: Boon or Bane
Neha Agarwal · Navyug Kanya Mahavidyalaya, India
Pharmaceuticals are essential to ensure the high standards of human health and wellbeing. Extensive and uncontrolled usage under different classes such as antibiotics, analgesics, antipyretics, antidepressant…
- Poster
Global drug development - Trends, challenges and opportunities
Gurpreet Singh · IQVIA, United Kingdom
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D…
- Poster
Tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT), A versatile carrier system for targeting cell cycle checkpoint pathways with potential anticancer activities
Tarek Aboul Fadl · Assiut University, Egypt
Cancer remains a global health threat despite advances in research and technology. According to International Agency for Research on Cancer, the cancer burden will increase by about 77% by 2050, further straining health…
- Poster
Surface chemistry and particle interactions in materials and their impact on powder performance
Teresa Carvajal · Purdue University, United States
Surface and physico-chemical properties are critical in formulation and in processes involving the handling, processing, packaging, shelf-life and bioavailability of medicines. In this presentation, we will explore and…
- Poster
From medicationalization to pharmaco pollution: Raising awareness on the hidden Costs of overprescribing
Andre Luiz Pereira · Escola de Saúde Pública do Estado de Minas Gerais (ESP-MG), Brazil
The overprescription of pharmaceuticals, a phenomenon known as medicationalization, has led to unintended environmental consequences, contributing to the rising issue of pharmacopollution. This article explores the…
- Poster
Understanding ABC transporters to navigate human diseases
Ruchika Bajaj · University of California San Francisco, United States
Membrane proteins constitute 30% of the genome in organisms and are involved in numerous physiological processes. ABC transporters is a class of membrane proteins which are ubiquitously present in all organisms, bind…
Present your research at PDDS 2027
Abstract submissions for the 2027 program are open · September 13–15, 2027 · Olympia Hotel, Events & Spa, Valencia, Spain.
Join the PDDS 2027 delegation
Valencia · September 13–15, 2027 · Hybrid · in-person & virtual
Attend without presenting.