Miroslav Radenkovic, University of Belgrade, Serbia
Pulmonary arterial hypertension (PAH) remains a devastating disease with high morbidity and mortality. It is uncommon, progressive and life-threatening blood vessel disorder differentiated by the constriction of minor pulmonary arteries and elevated blood pressure in the pulmonar [....] » Read More
Title : Ectopically expressed olfactory receptors as an untapped family of drug targets and discovery of agonists and antagonists of OR51E1, an understudied G protein-coupled receptor
Vladlen Slepak, University of Miami Miller School of Medicine, United States
Over 30% of pharmaceuticals act on G protein-coupled receptors (GPCRs), the largest family of human genes (~800). About 50% of GPCRs (~400) are Olfactory receptors (ORs); these GPCRs were originally discovered in the nasal epithelium, where they mediate the sense of smell. [....] » Read More
Title : Emerging formulation and delivery applications of Vitamin E TPGS
Andreas M Papas, Antares Health Products, United States
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through design-inspired biotech- & biopharma-driven applications and upgraded business marketing to secure the human healthcare and biosafety
Sergey Suchkov, The Russian University of Medicine and Russian Academy of Natural Science-Moscow, Russian Federation
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Genetic keys and nano locks: Unlocking personalized medicine
Srividya Narayanan, Northeastern University, United States
This presentation will explore the cutting-edge intersection of pharmacogenomics and nanomedicine, highlighting their combined potential to revolutionize drug delivery and personalized medicine. I will discuss how nanomedicine techniques are being leveraged to create targeted dru [....] » Read More
Title : Storage stability and solution binding affinity of an fc-fusion mimetic
Hanieh Khalili, University of East London, United Kingdom
The development of therapeutic proteins, particularly Fc-fusion proteins, has significantly advanced the treatment of many chronic diseases, including autoimmune disorders, cancers, and ocular diseases. Fc-fusion proteins combine the functional domain of a biologically active pro [....] » Read More
Title : Cholesterol lowering and regulation of inflammation by PCSK9
Maria Borrell, Sant Pau Research Institute, Spain
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Title : Strategies for addressing latent HIV-1 microglial cell reservoirs in adolescents and young adults with Neuro-HIV: Steps towards an HIV cure
Aarti V Belgamwar, Shri Vile Parle Kelvani Mandal’s Institute of Pharmacy, India
Although successful strides have been made in the HIV-1 response, ending AIDS threat by 2030 is a significant challenge, as HIV-1 infections among adolescents and young adult have not decreased fast enough to curb the epidemic. Globally, of the estimated 39.0 million people livin [....] » Read More
Title : Formulation and characterization of buccal films based on Sodium Alginate and Chitosan for using in Parkinson's disease
Krisztian Pamlenyi, University of Szeged, Hungary, Hungary
Parkinson's disease is the second most common neurodegenerative disease in the world, 16-20 thousand people suffer from this disease in Hungary and more than 10 million people worldwide. The symptoms can be various, both non-motor and motor symptoms can appear. The biggest pr [....] » Read More
Title : Pharmacology of chlorphenamine and Pseudoephedrine use in the common cold
Rassa Pegahi, UPSA, France
The common cold is the most frequent upper respiratory viral infection. Although benign, it represents a high socioeconomic burden. Many over-the-counter drugs are available to manage the symptoms of this condition, with antihistamines and vasoconstrictors being the most widely u [....] » Read More
Title : Assessment of inulin content in Arctium Lappa l. root extract: Potential for nutritional and medicinal applications
Elena Donici, State University of Medicine and Pharmacy, Republic of Moldova, Moldova, Republic of
Inulin, scientifically known as α-D-glucopyranosyl-β-D-fructofuranosyl-D-fructofuranoside, is a natural polysaccharide with diverse biological activities. It is widely used in the food and pharmaceutical industries as a soluble dietary fiber, sugar substitute, stabiliz [....] » Read More
Title : Evaluating Aronia Melanocarpa varieties for Pharmaceutical applications based on Polyphenolic content and Antioxidant activity
Iulia Bozbei, State University of Medicine and Pharmacy, Republic of Moldova, Moldova, Republic of
In recent years, the global community has been actively seeking plant-based sources with therapeutic and nutritional potential. The fruits of Aronia melanocarpa are widely recognized and utilized for these purposes. The challenges caused by global warming and changing climatic co [....] » Read More
Title : Spirulina platensis enriched with Silver Nanoparticles: A Novel Bioalternative against Antibiotic Resistance in Tunisian Urogenital Mycoplasma Strains
Boutheina Ben Abdelmoumen Mardassi, Pasteur Institute of Tunis, Tunisia, Tunisia
The emergence of antibioresistance in bacteria has become increasingly widespread, making it one of the major health problems of the century. As with many bacteria, in mycoplasmas, particularly urogenital mycoplasmas, the emergence of resistant strains in the Tunisian population [....] » Read More
Title : What Caffein brings to Paracetamol (Acetaminophen) in pain Management
Rassa Pegahi, UPSA, France
Background: Paracetamol is effective and safe in mild to moderate migraine attacks and episodes of tension-type headache (TTH). Few data are available on the use of paracetamol combined with caffeine, the aim of which is to achieve a higher analgesic efficacy of paracetamol [....] » Read More