Multiple sclerosis (MS) is an inflammatory demyelinating disorder, affecting the central nervous system with both immune and neurodegenerative components as the underlying causes. The aim of the study was to investigate the effects of IM253 (A herbal mixture of Rosa canina (Rosaceae), Urtica dioica (Urticaceae), and Tanacetum vulgare (Asteraceae) comprising selenium) treatment on inflammation and antioxidant capacity in the cerebral corpus callosum of C57BL/6 mice. During the course of the study, clinical evaluation was performed and eventually histological and molecular analysis on brain samples was carried out. Gene expression analyses demonstrated a significant reduction in the expression of pro-inflammatory cytokine coding genes as well as a significant increase in the expression of anti-inflammatories and anti-oxidant enzyme coding genes following treatment with IM253. Histological studies also showed that treatment with IM253 can reduce demyelination and inflammation. Overall, our results suggest that IM253 could ameliorate the severity of EAE, probably because of its anti-inflammatory and anti-oxidant properties, supporting the preclinical effects of IM253 as a potential therapeutic intervention.
Dr. Emran Esmaeilzadeh studied Medical genetics at the University of Social Welfare and Rehabilitation Science, Iran and graduated with a Ph.D. in 2019. He then joined the research group of Prof. Hamid Reza Khorram Khorshid at the fetal health Research Center, Hope Generation Foundation, Iran as an Associate Professor. Esmaeilzadeh has published more than 20 research articles in peer-reviewed journals and 4 books.