Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
It is well known that chronic obstructive pulmonary disease (COPD) is a common and devastating lung disease with a high mortality. The current therapeutics for this disease are neither specific nor very effective. Moreover, the pathogenesis mechanisms for this disease remain larg [....] » Read More
Pulmonary arterial hypertension (PAH) remains a devastating disease with high morbidity and mortality. It is uncommon, progressive and life-threatening blood vessel disorder differentiated by the constriction of minor pulmonary arteries and elevated blood pressure in the pulmonar [....] » Read More
High impact of Ab-proteases is valuable to monitor both clinical and subclinical courses of chronic autoimmune inflammation to predict stepwise transformations of the course, starting from the pre-illness and to prognosticate the clinical illness finally. This information would a [....] » Read More
Hydrogen sulfide is a toxic gas, which is an environmental and industrial pollutant. In recent years, however, it has been shown that this gas is also synthesized in the body, and acts as a potent vasodilator. Substance P is an 11 amino acid neuropeptide from the tachykinin famil [....] » Read More
Photoaging is one of the most common issues in the world, affecting nearly all women. The term "photoaging" describes the early aging of skin brought on by excessive exposure to ultraviolet radiation. Our study's objective was to evaluate Allantoin proposomes' a [....] » Read More
Thin endometrium, characterized by insufficient vascularization due to reduced vascular endothelial growth factor (VEGF), is a major cause of implantation failure and infertility. Inducing angiogenesis through targeted VEGF delivery presents a promising therapeutic strategy. This [....] » Read More
Background: In this study, we analysed the data on antimicrobial resistance in the bloodstream. This study aims to evaluate the bacterial resistance in the Gaza Strip and compare with that in other countries. Methods: This study was conducted retrospectively in the Indonesian [....] » Read More
Despite a 70% decline in childhood cancer death rates between 1970 and 2020, cancer remains the leading disease-related cause of death in children. While cancer treatment modalities are well understood, chemotherapy prescribing patterns in South Africa are not standardized. This [....] » Read More
Schistosomiasis, a waterborne neglected tropical disease (NTD) prevalent in sub-Saharan Africa and South-East Asia significantly impacts socio-economic development. Praziquantel (PZQ) serves as the primary treatment, effective against all human schistosome species. However, PZQ&# [....] » Read More
Background: Paracetamol is effective and safe in mild to moderate migraine attacks and episodes of tension-type headache (TTH). Few data are available on the use of paracetamol combined with caffeine, the aim of which is to achieve a higher analgesic efficacy of paracetamol [....] » Read More
The local production of active pharmaceutical ingredients (APIs) plays a vital role in strengthening national healthcare resilience by improving access to essential medicines and reducing dependence on imports and global supply chains. While the API industry is heavily driven by [....] » Read More
In recent years, the global community has been actively seeking plant-based sources with therapeutic and nutritional potential. The fruits of Aronia melanocarpa are widely recognized and utilized for these purposes. The challenges caused by global warming and changing climatic co [....] » Read More
Polymorphism—the ability of a compound to crystallize in more than one form—critically impacts the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs). Metastable polymorphs are particularly attractive due to their improved sol [....] » Read More
Current therapeutic strategies for breast cancer often lack tumor specificity, leading to off-target effects and systemic toxicity. The Y1 receptor (NPYR1), a subtype of the Neuropeptide Y receptor family, is highly expressed in 100% of NPYR-positive breast tumors but only in 58% [....] » Read More
Introduction: Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients with advanced fibrosis and poor cardiovascular outcomes. There [....] » Read More
For realizing pervasive and ubiquitous health and social care services, health and social care system have to undergo an organizational, methodological and technological transformation towards personalized, participative, preventive, predictive precision medicine. For designing a [....] » Read More
In this keynote talk, the traditional disc diffusion-test bioassay is revisited within the perspective of using a mathematical approach grounded on the standard as well as on the modified Hill model. Importantly, the Hill model was established in 1910 to account for the binding o [....] » Read More
This research explores the creation of a novel exosome delivery platform, termed Exo-ITC, tailored for use in dermatology. Exosomes, as extracellular vesicles, are pivotal in intercellular communication and exhibit substantial therapeutic potential in regenerative medicine and de [....] » Read More
Understanding drug transport in plasma is pivotal to optimizing therapeutic outcomes, as it governs drug distribution, efficacy, and clearance. A key factor in this process is protein binding, where drugs reversibly interact with plasma proteins such as albumin and alpha-1-acid g [....] » Read More
Perillyl alcohol is a naturally occurring monoterpene related to limonene. We have synthesized a clinical-grade version, called NEO100 (NeOnc Technologies, Inc., Los Angeles, California), which has revealed a variety of highly promising characteristics that we are exploring towar [....] » Read More
Prescribed drug abuse denotes the potential misuse of pharmacological formulations. Many regulatory agencies are working to improve rules for current and future drug formulations by using some level of abuse deterrent technologies. Opioids are often and widely misused substances [....] » Read More
The entire process of developing a drug from preclinical research to marketing can take approximately 12 to 18 years and often costs well over $1 billion. Global Top Pharmaceutical Companies based on projected R&D spending in 2026 are Roche, Johnson & Johnson, Merck & [....] » Read More
The morphology of nanosystems is one of the Critical Quality Attributes (CQAs) of the nanoformulations, affecting the interactions of cellular membranes as well as the release of the encapsulated active substances. Hybrid systems are mixed systems composed of different in-nature [....] » Read More
Background: Patients undergoing tooth movement in orthodontics often utilize non-steroidal anti-inflammatory medications (NSAIDs) to alleviate inflammation and discomfort.[1-3] On the other hand, the orthodontic profession is still debating whether or not NSAIDs slow down or hind [....] » Read More
The increase in life expectancy has led to a rise in age-related disorders, including neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Oxidative stress (OS) plays a crucial role in the pr [....] » Read More
One of the primary challenges in pharmaceutical dosage form development is the poor solubility of certain drugs, particularly those classified as Biopharmaceutics Classification System (BCS) Class IV. These drugs exhibit low solubility and permeability, resulting in suboptimal ph [....] » Read More
Mineral and metallic nanomedicines are a precious resource found in the Ayurvedic medical system. Rasashastra is an Ayurvedic branch that deals with the preparation and therapeutic use of nanomedicines. A weak interdisciplinary collaboration between science and Ayurveda ultimatel [....] » Read More
Doxorubicin (DXR) is a powerful chemotherapeutic drug commonly used to treat cancers such as breast cancer, bladder cancer, Kaposi's sarcoma, and lymphoma. However, its clinical use is often limited by severe side effects, including cardiomyopathy, bone marrow suppression, an [....] » Read More
Over two decades, a large number of nucleosides have been synthesized, which demonstrated potent antiviral and antitumour activities and have become cornerstones of treatment for patients with cancer or viral infections. Oligonucleotide-based antisense strategies represent a uniq [....] » Read More
Pharmaceuticals have undoubtedly lengthened life spans, cured millions from deadly diseases, and made life comfortable and free from pain. This very success has now led to their emergence as rapidly growing environmental pollutants and contaminants. Acetaminophen (4’-hudrox [....] » Read More
Necrotizing fasciitis (NF) is a rare yet aggressive bacterial infection that rapidly destroys soft tissues, including the fascia. Clindamycin, a potent antibiotic inhibiting bacterial protein synthesis, is the primary treatment choice. However, its limited permeability and low to [....] » Read More
Therapeutic drug monitoring (TDM) is essential in preterm infants due to their unique pharmacokinetics and heightened susceptibility to drug toxicity and therapeutic inefficacy. This study proposes a structured quality assurance (QA) framework to enhance TDM practices in neonatal [....] » Read More
The Cucurbitaceae family, which comprises more than 900 species of gourds, melons, squash, and cucumbers, has long been valued for its nutritional and medicinal properties. Recent phytochemical studies suggest that it contains bioactive compounds, including alkaloids, flavonoids, [....] » Read More
Dibutyl phthalate and nonylphenol from endocring disruptors were removed photocatalycally with nanocomposites derivated from printed circuit board wastes. These wastes represent 3% of the total mass of waste electric and electronic equipment and have revealed the following compos [....] » Read More
The advantages of 3D bioprinting, tissue engineering and regenerative medicine represent a powerful potential for everyone who wants to always be healthy, young or rejuvenate. Overcome the shortage of organs for implantation and personal hormone replacement therapy for everyone w [....] » Read More
Ayurveda is science of the life. Maintenance of the health of healthy individuals and Treatment of the diseased are the main principles of Ayurveda management. Acharya Sushruta, The Father of Surgery, explained different types of surgeries and documented procedures in a sophistic [....] » Read More
In the realm of cerebrovascular incidents, the safeguarding of cerebral vasculature is recognized as a paramount goal. This talk will focus on the recent advances made in the domain of nanoparticle mediated drug delivery systems for cerebrovascular disorders. Worldwide in our eff [....] » Read More
Psychedelic drugs acting upon the serotonergic receptors are currently considered to be not only substances of abuse, but also the hope of new therapies of mental problems such as depression, PTSD and eating disorders; pain; inflammations or even asthma. The main challenge in thi [....] » Read More
Cancer remains a global health threat despite advances in research and technology. According to International Agency for Research on Cancer, the cancer burden will increase by about 77% by 2050, further straining health systems, people and communities. Although cancer chemotherap [....] » Read More
The presence of genotoxic impurities like nitrosamine in pharmaceutical products has become a pressing global safety concern due to their potential carcinogenic and mutagenic e8ects. NAs, particularly N-nitroso compounds, are classified as probable human carcinogens, raising the [....] » Read More
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. However, the drug has the unintentional side effects of erectile dysfunction and infertility. The impact on [....] » Read More
A large number of organic solvents (chloroform, hexane, methanol, dimethyl formamide, ethanol, benzene, toluene, carbon tetrachloride, methylene chloride, acetonitrile etc) are employed in various types of pharmaceutical analysis viz. HPLC, TLC, HPTLC, UV spectrophotometry, Titri [....] » Read More
This study presents a machine learning approach to classify diabetes status using the CDC BRFSS 2015 dataset, which includes over 250,000 self-reported health records across 22 variables. The goal was to develop a multi-class classification model to identify individuals as No, Ye [....] » Read More
Background: CYP2C9 is a major cytochrome P450 enzyme responsible for metabolizing approximately 15% of clinically prescribed drugs, including warfarin, losartan, and NSAIDs. Genetic variants influencing CYP2C9 expression and activity contribute to variability in drug metabol [....] » Read More
Title : Ectopically expressed olfactory receptors as an untapped family of drug targets and discovery of agonists and antagonists of OR51E1, an understudied G protein-coupled receptor
Vladlen Slepak, University of Miami Miller School of Medicine, United States
Over 30% of pharmaceuticals act on G protein-coupled receptors (GPCRs), the largest family of human genes (~800). About 50% of GPCRs (~400) are Olfactory receptors (ORs); these GPCRs were originally discovered in the nasal epithelium, where they mediate the sense of smell. [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through de-sign-inspired biotech- & biopharma-driven applications and upgraded business mar-keting to secure the human healthcare and biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
Traditionally, a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to [....] » Read More
Title : Genetic keys and nano locks: Unlocking personalized medicine
Srividya Narayanan, Northeastern University, United States
This presentation will explore the cutting-edge intersection of pharmacogenomics and nanomedicine, highlighting their combined potential to revolutionize drug delivery and personalized medicine. I will discuss how nanomedicine techniques are being leveraged to create targeted dru [....] » Read More
Title : Storage stability and solution binding affinity of an fc-fusion mimetic
Hanieh Khalili, University of East London, United Kingdom
The development of therapeutic proteins, particularly Fc-fusion proteins, has significantly advanced the treatment of many chronic diseases, including autoimmune disorders, cancers, and ocular diseases. Fc-fusion proteins combine the functional domain of a biologically active pro [....] » Read More
Title : Design and computational analysis of a peptide analogue with a WXXW motif: A membrane-active and reversible drug binding peptide to overcome cancer drug resistance
Nurul Ain binti Mohammad Hamdi, University of Manchester, United Kingdom
Membrane-active peptides are known for their ability to transport therapeutic agents across cellular membranes, thereby enhancing intracellular delivery. In this study, we designed a membrane-active peptide analogue by incorporating a drug-binding sequence. This modification aims [....] » Read More
Title : Pharmacology of chlorphenamine and pseudoephedrine use in the common cold
Rassa Pegahi, UPSA, France
The common cold is the most frequent upper respiratory viral infection. Although benign, it represents a high socioeconomic burden. Many over-the-counter drugs are available to manage the symptoms of this condition, with antihistamines and vasoconstrictors being the most widely u [....] » Read More
Title : Cholesterol lowering and regulation of inflammation by PCSK9
Maria Borrell, Sant Pau Research Institute, Spain
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Title : Formulation and characterization of buccal films based on sodium alginate and chitosan for using in parkinson's disease
Krisztian Pamlenyi, University of Szeged, Hungary
Parkinson's disease is the second most common neurodegenerative disease in the world, 16-20 thousand people suffer from this disease in Hungary and more than 10 million people worldwide. The symptoms can be various, both non-motor and motor symptoms can appear. The biggest pr [....] » Read More
Title : The promise of nanotechnology in personalized & precision medicine: Drug discovery & development being partnered with nanotechnologies via the revolution at the nanoscale
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences & InMedStar, Russian Federation
A new systems approach to subclinical, predictive and/or diseased states and wellness resulted in a new Hi Tech trend in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, despite breakthroughs in designed-driven research that have led to an in [....] » Read More
Title : Lipid nanoparticles formulations: From bench scale to industrial scale
Mohammad Obeid, RAK Medical and Health Sciences University, United Arab Emirates
Lipid nanoparticles are self-assembling vesicles obtained by hydrating a mixture of non-lipids and cholesterol and are suitable as carriers of drugs and biopharmaceuticals. It is desirable to be able to accurately control size and polydispersity of the vesicles as this can impact [....] » Read More
Title : Strategies for addressing latent HIV-1 microglial cell reservoirs in adolescents and young adults with neuro-HIV: Steps towards an HIV cure
Aarti V Belgamwar, Shri Vile Parle Kelvani Mandal’s Institute of Pharmacy, India
Although successful strides have been made in the HIV-1 response, ending AIDS threat by 2030 is a significant challenge, as HIV-1 infections among adolescents and young adult have not decreased fast enough to curb the epidemic. Globally, of the estimated 39.0 million people livin [....] » Read More
Title : Personalized medicine: Tailoring drug delivery systems for targeted therapeutic efficacy
Monica Arora, Villa College, Maldives
Personalized medicine has emerged as a transformative approach in healthcare, focusing on optimizing therapeutic outcomes by tailoring drug delivery systems to individual patient needs. Traditional drug administration methods often exhibit limitations such as systemic toxicity, p [....] » Read More
Title : Innovations in rivastigmine delivery: Nanostructured lipid carriers encapsulated in microneedles for enhanced transdermal delivery
Shereen M Assaf, Jordan University of Science and Technology, Jordan
Rivastigmine (RHT), used in the management of Alzheimer's disease, reduces acetylcholine degradation and enhances the cognitive function. Challenges in RHT delivery arise due to its limited ability to permeate the brain, short half-life, low bioavailability, and abdominal sid [....] » Read More
Title : Patient and clinician perspectives on pharmacogenetic testing for antipsychotics
Maria Richards Brown, University College London, United Kingdom
Medications are often prescribed using a trial-and-error approach, which can lead to poor treatment outcomes, non-adherence, and adverse drug reactions. To address this, there is increasing focus on personalizing medicine. For example, pharmacogenetics investigates how one’ [....] » Read More
Title : The influence of CYP450 variation and smoking on clozapine metabolism: A mixed- effects model using longitudinal patient data
Daisy Mills, University College London, United Kingdom
Clozapine is an atypical antipsychotic regarded as the gold-standard for treatment-resistant schizophrenia, yet its metabolism remains highly variable. The cytochrome P450 enzymes CYP1A2, CYP2D6, and CYP2C19 are involved in clozapine metabolism, though the clinical significance o [....] » Read More
Title : Advances in hydrophilic drug delivery: Encapsulation of biotin in alginate microparticles
Iria Naveira Souto, Reig Jofre | University of Barcelona, Spain
The encapsulation of hydrophilic drugs within microparticles has gained significant interest in drug delivery systems due to their potential to improve the stability, bioavailability, and controlled release of therapeutic agents. Biotin, a water-soluble vitamin, faces challenges [....] » Read More
Title : Astrotactin 2 as novel analgesic target candidate for cancer pain and opioid sparing: An exploratory genetic polymorphism analysis
Mizuho Sumitani, The University of Tokyo Hospital, Japan
Introduction: Cancer pain impairs not only physical functions but also social functions and roles. Neuronal protein astrotactin 2 (ASTN2) fulfills a function to regulate the release of neuronal adhesions to the glial fiber. Genetic variability in the ASTN2 gene was reportedly ass [....] » Read More
Title : Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce enos phosphorylation in vascular endothelial cells
Haitham A Saleh, Qatar University, Qatar
Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as atherosclerosis, coronary artery disease, and hypertension. [....] » Read More
Title : The future of type 2 diabetes management: From trial and error to a QbD driven approach to zein microparticle therapeutics
Puja Nayak, Guru Ghasidas Vishwavidyalaya, India
Introduction- Diabetes mellitus, a growing global health concern, necessitates innovative drug delivery strategies to overcome limitations associated with conventional therapies, such as poor bioavailability and systemic toxicity. Nanotechnology offers promising solutions, partic [....] » Read More
Title : Assessment of inulin content in Arctium Lappa l. root extract: Potential for nutritional and medicinal applications
Elena Donici, State University of Medicine and Pharmacy, Moldova, Republic of
Inulin, scientifically known as α-D-glucopyranosyl-β-D-fructofuranosyl-D-fructofuranoside, is a natural polysaccharide with diverse biological activities. It is widely used in the food and pharmaceutical industries as a soluble dietary fiber, sugar substitute, stabiliz [....] » Read More
Title : Spirulina platensis enriched with silver nanoparticles: A novel bio alternative against antibiotic resistance in Tunisian urogenital mycoplasma strains
Boutheina Ben Abdelmoumen Mardassi, Pasteur Institute of Tunis, Tunisia
The emergence of antibioresistance in bacteria has become increasingly widespread, making it one of the major health problems of the century. As with many bacteria, in mycoplasmas, particularly urogenital mycoplasmas, the emergence of resistant strains in the Tunisian population [....] » Read More
Title : Intelligent delivery of 5-fluorouracil using smart polymers
Mutaz S Salem, Jordan University of Science and Technology, Jordan
Colonic drug delivery systems have been utilized to treat a wide range of bowel illnesses, including colorectal cancer, ulcerative colitis, diverticulitis, Crohn's disease, and IBS. These systems can improve therapeutic efficacy by limiting undesired absorption in other parts [....] » Read More