The full PDDS 2019 scientific program across 3 days — keynotes, oral presentations, and posters. Talks are ordered by program prominence within each day.
Day 1
- Keynote
Novel developments in lipid-based multifunctional combination nanopreparations for multidrug resistant cancer
Vladimir P. Torchilin · Northeastern University, United States
Therapy of multidrug resistant cancers could be significantly enhanced by using siRNA down-regulating the production of proteins involved in cancer cell resistance, such as Pgp or survivin. Even better response could be…
- Keynote
Taking your active from the lab to scale-up formulation development of a topical delivery systems
Robert Houlden · Formulytica Pty. Ltd, Australia
The presentation will discuss (with practical examples) the steps required to take a pharmaceutical active from the research lab to developing a topical oil-in-water vehicle or gel for drug delivery. Preformulation…
- Keynote
Government and industry response to the US opioid epidemic
Robert P. Bianchi · Prescription Drug Research Center, United States
Prescription drug abuse has been declared an epidemic in America by the Centers for Disease Control and Prevention and the president of the United States which makes up 4.6 percent of the world’s populations but…
- Keynote
The use of self-immolative polymers to control cellular delivery
Georgina Kate Such · The University of Melbourne, Australia
Nanoparticles are of interest for the delivery of therapeutics as they are capable of targeting drug release specifically to diseased cells and tissue. Self-assembled polymeric carriers have generated particular…
- Oral · In-Person
Docetaxel-liposomes prepared by the dual centrifugation method: Effect of propylene glycol and lipid charge on liposomal characteristics
Ann Mari Holsaeter · The Arctic University of Norway, Norway
Docetaxel (Doc) is a highly lipophilic anticancer drug. The current Doc treatment gives several side effects that might be prevented when Doc is incorporated in liposomes. The first aim of this study was to adapt the…
- Oral · In-Person
Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments
Jan Tavernier · Ghent University, Belgium
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on…
- Oral · In-Person
Lipid and carbohydrate based delivery vesicles for gene therapeutics: Approaching difficult diseases
Kira Astakhova · University of Southern Denmark, Denmark
RNA therapeutics is a broad group of RNA oligo- and polymers that knock down, insert or replace a disease associated RNA. RNA therapeutics act via diverse biological mechanisms including e.g. antisense oligonucleotides…
- Oral · In-Person
In vitro modeling of the blood-brain barrier to assess CNS drug delivery
Fabien Gosselet · Blood-brain barrier laboratory, Artois University, France
The blood-brain barrier (BBB) is located at the brain microvessel level and isolates the brain from the whole body, thus restricting molecule and cell exchanges between cerebral and peripheral compartments. BBB…
- Oral · In-Person
Prototyping and evaluating a novel humanoid chewing robot for drug delivery using a medicated chewing gum
Kazem Alemzadeh · University of Bristol, United Kingdom
The global pharmaceutical market in 2009 was estimated at $837 billion and the US had a largest market share worth $300 billion per annum. It is estimated that the market could be worth nearly $1.6 trillion by 2020. The…
- Oral · In-Person
Multifunctionalized and targeted biocatalytic nanoreactor for combinatory treatment of ER+ breast cancer
Rafael Vazquez-Duhalt · Universidad Nacional Autónoma de México, Mexico
Background: Tamoxifen is the standard endocrine therapy for breast cancers, which require metabolic activation by cytochrome P450 enzymes (CYP). However, the lower and variable concentrations of CYP activity at the…
- Oral · In-Person
New approach to study difference in NSAIDs enantiomer activity, including chiral inversion
Tatyana V. Leshina · Voevodsky Institute of Chemichal Kinetics and Combustion SB RAS, Russian Federation
The difference in the medical properties of the enantiomers of many chiral drugs is a well-known fact. This is a big problem, since most drugs are still used in the form of racemates. The latter is connected with the…
- Oral · In-Person
In situ delivery and production system of anti-cancer molecules with gene-engineered bifidobacterium
Shun’ichiro Taniguchi · Shinshu University School of Medicine, Japan
Regardless of recent rapid progresses in cancer therapy by molecular-targeting and regulating immune check points, the side effects of those treatments are still troublesome for the patients to be overcome. We have…
- Oral · In-Person
Influence of mucoadhesivity on the bioavailability of nanoparticulate drug delivery systems
Ylenia Zambito · University of Pisa, Italy
The oral administration route is by far the preferred one and more than 80% of drugs are taken orally. Since the gastrointestinal (GI) tract is the primary site of drug delivery, many researchers have focused their…
- Oral · In-Person
Systemic liver-targeting delivery of a novel DNA/RNA heteroduplex oligonucleotide via an enteral route
Chie Watanabe · Josai University, Japan
Since the advent of antisense technology, oligonucleotide drugs have attracted a greater deal of attention as next-generation therapeutics, which can be selectively delivered to their target tissue to obtain effective…
- Oral · In-Person
Physicochemical and biophysical study of mechanisms the drugs bioavailability enhancement with new multifunctional delivery systems
Nikolay E. Polyakov · Voevodsky Institute of Chemical Kinetics and Combustion, Russian Federation
One of the most important problems of modern pharmaceutics is the low solubility and bioavailability of drug compounds. These problems are solved by using various delivery systems that can form water-soluble…
- Oral · In-Person
Designing ADME formulations with matching exposures to amorphous solid dosage forms
Aditya Tatavart · Merck Sharp & Dohme Inc, United States
Amorphous solid dispersion (ASD) based formulations have been frequently used to improve the bioavailability of poorly soluble drugs. However, common processes to produce ASDs are not feasible for absorption…
- Oral · In-Person
Wound healing mats made of layer by layer coated nanoparticles and electrospun nanofibers
Gulcin Arslan Azizoglu · Ege University, Turkey
Introduction: A broad range of diseases could be altered using layer-by-layer (LbL) based nanoparticles which is an emerging and powerful method to develop multifunctional nanomedicines. In this study, a combined…
- Oral · In-Person
In vitro model of diclofenac sodium gel delivery through pig skin
Enkelejda Goci · Aldent University, Albania
At first sight transdermal drug delivery appears to be a simple form of treatment, but closer examination reveals that dermatological form doses represent one of the most difficult aspects of the science of…
- Oral · In-Person
Influence of formulation and freeze drying process variations on protein stability
Paritosh Pande · IMA Life North America and University of Connecticut, United States
Nearly half of the therapeutic proteins undergo freeze drying process to improve their long-term storage stability but the inability to directly control the product temperature during freeze-drying process can lead to…
- Oral · In-Person
Valproic acid encapsulated biodegradable microneedles for treatment of androgenetic alopecia
Shayan Fakhraei Lahiji · Yonsei University, Korea, Republic of
There are numerous genetic and environmental factors responsible for occurrence of male pattern hair loss known as androgenetic alopecia. Despite considerable medical advancements, the current treating agents, are…
- Oral · In-Person
Therapeutic effects of trehalose liposomes against tumors along with apoptosis
Yoko Matsumoto · Sojo University, Japan
Trehalose stabilizes membranes and proteins in cells most likely by hydrogen bonding. Trehalose liposomes (DMTre) composed of L-α-dimyristoylphosphatidylcholine (DMPC) and trehalose micelles (TreC14) have been produced…
Day 2
- Keynote
Nanoparticle delivery of natural products for the treatment of lung cancer
Gillian Hutcheon · Liverpool John Moores University, United Kingdom
Cancer is the leading cause of death worldwide, accounting for 8.8 million deaths, with lung cancer attributing to 1.69million of these deaths in 2015. The application of natural products to treat various diseases, such…
- Keynote
Synthesis and physicochemical analysis of multi-component phases in drug development
Mino R. Caira · University of Cape Town, South Africa
Supramolecular modification of active pharmaceutical ingredients (APIs) and new chemical entities (NCEs) to enhance their physicochemical properties and improve their delivery can be achieved via crystal engineering…
- Keynote
Preclinical validation of a cell penetrating and interfering peptide
Angelita Rebollo · CIMI Paris, France
The interaction between intracellular caspase 9 and serine/threonine phosphatase PP2A proteins is critical to apoptosis. We have designed a Cell Penetrating and Interfering Peptide (CP and IP), Mut3DPT-C9, which…
- Keynote
Facile preparation and characterization of robust metal-free nitroxide-based magnetic mixed micelles as MRI-visible drug delivery carrier
Rui Tamura · Kyoto University, Japan
We reported that chiral all-organic rod-like liquid crystalline (LC) compounds with a five-membered cyclic nitroxide unit in the central core position exhibited the spin glass-like inhomogeneous ferromagnetic…
- Oral · In-Person
Nano- versus micro-particles for S-nitrosoglutathione formulation
Marianne Parent · Université de Lorraine, France
S -nitrosoglutathione (GSNO) is a physiological nitric oxide donor and a promising drug for several acute or chronic diseases (e.g. stroke, atherosclerosis, …). However, this nitrosated tripeptide is highly hydrophilic…
- Oral · In-Person
Pseudomonas aeruginosa type 3 secretion system mediated antigen delivery for cancer immunotherapy
Toussaint Bertrand · University Grenoble Alpes, France
Live-attenuated bacterial vectors for antigens delivery have aroused growing interest in the field of cancer immunotherapy. Their potency to stimulate innate immunity and to promote intracellular antigen delivery into…
- Oral · In-Person
Engineering novel selectivity into metalloantibodies germline-encoded precursor to the murine anti-S1P metalloantibody in E.coli and baculovirus-insect cell system
Elinaz Farokhi · San Diego State University, United States
The scientific aspect of this research focuses upon the use of metals by antibodies in the mammalian adaptive immune system. It is estimated that one third of all proteins are metalloproteins. However, the use of metals…
- Oral · In-Person
Discovery of novel bacterial genes encoding the enzymes acting on modified uracil/uridine derivatives and their use for gene therapy in cancer treatment
Jaunius Urbonavičius · Vilnius Gediminas Technical University, Lithuania
Modified nucleotides are present in several RNA species in all Domains of Life. While the biosynthetic pathways of these nucleotides were well studied in recent years, much less attention was drawn to the degradation of…
- Oral · In-Person
Drug delivery to the skin: Nanostructures for the treatment of precancerous actinic keratosis
Silvia Tampucci · University of Pisa, Italy
Actinic keratosis (AK) is a common skin disease characterized by cutaneous lesions in the sun-exposed areas of the skin; it is often asymptomatic, but if left untreated it may be the precursor of squamous cell carcinoma…
- Oral · In-Person
Liposomes as valuable drug delivery systems for siRNA and Hsp90 inhibitors to target triple negative breast tumors
Juliette Vergnaud-Gauduchon · Université Paris-Sud, France
Triple Negative Breast Cancers (TNBC) are not efficiently treated by specific targeted therapy. New strategies must be envisaged and nanocarriers appear as good candidates to overcome low efficacy of drugs or resistance…
- Oral · In-Person
A RNA producing DNA hydrogel as a platform for a high performance RNA interference system
Nokyoung Park · Myongji University, Korea, Republic of
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This…
- Oral · In-Person
Metal-organic framework nanoparticles preparation of sildenafil: A new window in the treatment of pulmonary arterial hypertension
Haissam Abou Saleh · Qatar University, Qatar
Background: Nanomedicine is an attractive and promising field that uses nanoparticles to serve as drug carriers. This field can improve the treatment of the complications of cardiovascular diseases including pulmonary…
- Oral · In-Person
Release and activity of the broad spectrum antibiotic Rifampicin from biodegradable polymer PLGA
Justine Fraser · The University of Strathclyde, United Kingdom
Medical device infection is one of the most problematic issues associated with implanted medical devices. More than 60% of nosocomial infections are related to a medical device, with treatment being particularly…
- Oral · In-Person
Role of the optimal dynamic state and stabilized catalytic complex for rational design of pharmaceutical enzymes: Engineering of streptokinase with enhanced, fibrin-dependent activity
Farzin Roohvand · Pasteur Institute of Iran, Iran (Islamic Republic of)
Plasminogen activators (PAs), compounds that convert the blood plasminogen (Pg: inactive proenzyme) to plasmin (Pm: active enzyme) are used in the treatment of thrombotic disorders like myocardial infarction.…
- Oral · In-Person
Pharmacovigilance: Aims, challenges and perspectives
Razan Ghattas Mhanna · Lebanese International University, Lebanon
Drug safety and pharmacovigilance remains a dynamic clinical and scientific discipline. Pharmacovigilance is defined by the World Health Organization (WHO) as ’the science and activities relating to the detection…
- Oral · In-Person
Original Synthesis of natural acetogenins, fattyacids and lembehynes as a potential drugs for treatment of cancer and neurodegenerative diseases
Vladimir A. D’yakonov · Institute of Petrochemistry and Catalysis of RAS, Russian Federation
The report discusses the latest achievements of the authors in developing original methods for stereoselective synthesis of natural acetogenins, higher bis-methylene-separated(interrupted) di- and trienoic acids…
- Oral · In-Person
The nuclear membrane as a barrier to the action of anthracycline chemotherapeutics
Gulnihal Ozcan · Koc University Research Center for Translational Medicine, Turkey
Anthracyclines are one of the most commonly used and most effective chemotherapeutic agents in a wide variety of cancers. Their primary mechanism of action is through binding to DNA, which leads to inhibition of DNA…
- Oral · In-Person
Global legal tools for pharmacovigilance and risk control
Eliana Silva De Moraes · Partner at Silva de Moraes Associes, France
For those who works in the pharmaceutical sector knows that doing business globally is a challenge. The regulatory affairs profdessional needs to have a broadly view of the current trends such as risk management…
- Oral · In-Person
Self-propelled objects with high autonomy for transportation
Satoshi Nakata · Hiroshima University, Japan
Self-propelled objects have been studied as potential carriers to transport materials or themselves to a target location in a confined space, mimicking the behaviours of bacteria. Most self-propelled objects exhibit…
- Poster · In-Person
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Mamuka Kvaratskhelia · University of Colorado School of Medicine, United States
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based…
- Poster · In-Person
Study of the capability of Chitosan-Glutathione nanoparticles to modulate redox state in human Chondrocytes
Roberto Diaz-Torres · National University of Mexico, Mexico
The use of nanometric systems as disposal of biologically active substances is a successful tool in different areas of knowledge. In this research we studied nanometric systems with antioxidant capacity to modulate…
- Poster · In-Person
The biomedical application of biogenic silver nanoparticles produced from Cotyledon orbiculata
Samantha Meyer · Cape Peninsula University of Technology, South Africa
The biogenic synthesis of nanomaterials is considered an eco-friendly approach to nanomaterial synthesis that produces nanomaterials that is more biocompatible and therefore more suitable for biomedical applications.…
- Poster · In-Person
Nano-amorphous abiraterone acetate formulation with improved bioavailability and eliminated food effect
Tamás Jordán · NanGenex Inc, Hungary
Abiraterone acetate (AA) is a poorly water-soluble drug molecule indicated for patients with metastatic castration resistant prostate cancer. It is a prodrug, which is converted to abiraterone in vivo. The oral dose is…
- Poster · In-Person
Dissolution study of drug release from biopolymer matrix tablets
Kevin Matzick · University of Pardubice, Czech Republic
Aim of the work is to compare chosen biopolymers and critically evaluate their ability to provide of model drugs with different solubility. Chitosan and Alginate-natrium are natural derivates of cellulose that are…
- Poster · In-Person
TAA-induced liver damage in KLF10 knockout mice
Azra Memon · Inha University, Korea, Republic of
The liver plays an important role in regulating physiological functions such as detoxification of harmful substances. Liver injuries and diseases cause necrosis and apoptosis mainly due to an imbalance in cell…
- Poster · In-Person
Neuropeptide Y-based recombinant peptides improve bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization
Hee Kyung Jin · Kyungpook National University, Korea, Republic of
Hematopoietic stem/progenitor cell (HSPC) mobilization is an essential homeostatic process regulated by the interaction of cellular and molecular components in bone marrow niches. It has been shown by others that…
- Poster · In-Person
Antitumor effects of retargeted AAV2 virus on ovarian cancer in vivo
Hyung Jun Ahn · Korea Institute of Sceince and Technology, Korea, Republic of
Adeno-associated virus (AAV) is a promising vector for systemic delivery of siRNA due to its long-term expression ability without immunogenicity and pathogenicity. However, its broad host tropism and lack of tissue…
- Poster · In-Person
Niosomal encapsulation of Curcumin: Characterization and its potential as a therapeutic intervention in asthma
Dinesh Kumar Chellappan · International Medical University, Malaysia
Asthma is a disease which occurs due to chronic inflammation in the airways. The most prominent clinical features of asthma are constriction and obstruction of the airway, which renders breathing difficult and…
- Poster · In-Person
Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells
Jiyon Lee · Konkuk University, Korea, Republic of
Background: Calotropis gigantea (CG), a tall and waxy flower that has been used in treating fever, indigestion, rheumatism, leprosy and leukoderma as traditional remedies. However, it has not yet been examined about the…
- Poster · In-Person
Kinetics of pentoxifylline release from hydrophilic, lipophilic and dual matrix tablets
Barbora Slezáková · University of Pardubice, Czech Republic
The aim of this study was to evaluate the possibilities of using matrix tablets and dual matrix tablets containing hydrophilic and/or lipophilic retardant for extended release of pentoxifylline. Polyvinyl alcohol…
- Poster · In-Person
Development of rotigotine nanoparticles and its effect on haloperidol induced Parkinsonian symptoms in rats
Subrat Kumar Bhattamisra · International Medical University, Malaysia
Rotigotine, a non-ergot dopamine agonist (D2-D5 receptors) drug used in the treatment of idiopathic Parkinson’s disease (PD). Presently, its clinical use is very limited due to its poor oral bioavailability. Thus, this…
- Poster · In-Person
Synthesis, evaluation and computational simulation of novel coumarin derivatives as potential acetylcholinesterase inhibitors
Haeil Park · Kangwon National University, Korea, Republic of
Alzheimer’s disease (AD) is characterized by a slow but progressive deterioration in cognitive performance. The decrease of acetylcholine (ACh) due to cholinergic neuronal dysfunction in the hippocampus and cortex could…
- Poster · In-Person
Characterization and validation of tumor cell-selective penetrating peptides
Angelita Rebollo · CIMI Paris, France
The aim of our project is to develop innovative tumor-specific approaches for transport of bioactive compounds in tumor cells for targeted therapy in cancer. Tumor Penetrating Peptides (TPP) are a subclass of tumor…
- Poster · In-Person
Freshwater sapropel extract for use in medicine and pharmaceutics
Aneka Klavina · Rigas Stradiņš University, Latvia
Sapropel is organic sediment that accumulates underwater in shallow to deep marine basins, lagoons and lakes. The sapropel forms by slow decomposition process of phytoplankton, waste material from higher plants and…
- Poster · In-Person
Fabrication and characterization of transdermal patch loaded with Ascorbic acid
Ahlam Zaid Alkilani · Zarqa University, Jordan
Ascorbic acid AA (vitamin C) has been widely used in the cosmetic field as an anti-wrinkle agent due to a variety of biological, pharmaceutical and dermatological functions. The main cause of aging is a decline in…
- Poster · In-Person
Nanoemulsion–laden organogels of lidocaine as lipid–based systems for topical delivery
Rania Hamed · Al-Zaytoonah University of Jordan, Jordan
Conventional organogel and nanoemulsion–laden organogels (nanoemulsion organogels) were used to deliver the lipophilic drug, lidocaine, topically. Optimized formulations of lidocaine–loaded nanoemulsions of oil, water…
- Poster · In-Person
Anti-cancer effect of Tuberatolide B in MDA-MB-231 cells through induction of ROS and inhibition of STAT3 pathway
Areumi Park · Korea Institute of Ocean science & Technology, Korea, Republic of
Tuberatolide B (TTB, C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum . However, the anticancer effects of TTB remain unknown. In this study, we demonstrate that…
- Poster · In-Person
Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway
Soo-Jin Heo · Korea Institute of Ocean science & Technology, Korea, Republic of
Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can…
- Poster · In-Person
Saringosterol acetate suppressed hepatocelluar carcinoma growth and metastasis in a zebrafish xenograft model
Eun-A Kim · Korea Institute of Ocean science & Technology, Korea, Republic of
Saringosterol acetate (SSA) can be isolated from an edible brown alga, Hizikia fusiforme . In this study, we developed an adult zebrafish human hepatocellular carcinoma (HCC) xenograft model to confirm our previous…
- Poster · In-Person
Molecular weight characterization of sodium carboxymethyl cellulose by advance polymer chromatography
Ekaterina Sobich · AbbVie Deutschland GmbH & Co. KG R&D, Germany
Advanced polymer chromatography (APC) is a size exclusion chromatography (SEC) designed by Waters for fast, efficient, and robust polymer characterization. The molecular weight (Mw) separation range is from 100 Da to 2…
- Poster · In-Person
Strategies to increase the passage of large molecules through the blood brain barrier
Charlotte Lombardi · Grenoble-Alpes University, France
The diagnosis of Alzheimer's disease (AD), a neurodegenerative disease that affects cognitive functions, remains difficult and the first noticeable symptoms, as well as the detection of current biomarkers, means that…
- Poster · In-Person
Peptide functionalized nanoparticles for the selective induction of apoptosis in target cells
Mervin Meyer · University of the Western Cape, South Africa
The unique optical properties of gold nanoparticles (AuNP) can facilitate the development of ultrasensitive imaging-based therapeutic systems. Several studies have demonstrated the application of AuNPs for targeted drug…
- Poster · In-Person
Cell-free expression of a membrane antigen for vaccine uses
Geraldine Mayeux · University Grenoble Alpes, France
Pseudomonas aeruginosa is an opportunistic bacterium and is the second-leading cause of nosocomial infections and pneumonia in hospitals, which are mainly acquired in intensive care units. The pathogen is also…
- Poster · In-Person
Thermoresponsive in situ gelling systems for ophthalmic drug delivery
Concepción Renedo Laguna · University of Seville, Spain
The administration of drugs through the ocular topical route supposes a considerable reduction of its bioavailability (naso-lacrimal drainage, protection mechanisms of the eye such as blinking and loss towards systemic…
Day 3
- Keynote
Cell-penetrating peptides and delivery of oligonucleotides
Ulo Langel · Stockholm University, Sweden
PepFect delivery technology for oligonucleotide transfection by transportan based cell-penetrating peptides in vitro and in vivo is described. Recent data on mechanisms and applications of PepFect strategies are…
- Keynote
Strategies to improve drug delivery to the lungs from dry powder inhalers
El Hassane Larhrib · University of Huddersfield, United Kingdom
The respiratory route has been used to deliver drugs into the human body for centuries. However, the airways and lungs have a complex physio-anatomical architecture, thus making drug delivery to the lungs more…
- Keynote
Pharmaceutical applications of graphene-based nanomaterials in cancer theranostics
Marlene Lúcio · University of Minho, Portugal
After its astonishing and unexpected discovery in 2004, graphene, a two-dimensional nanomaterial made of single-layered carbon molecules organized in a honeycomb cross section, has been broadly investigated for an…
- Keynote
Designing extracellular vesicles for bio-camouflaged drug delivery and cell-free regenerative medicine
Amanda Silva Brun · Universite Paris Diderot, France
Extracellular vesicles (EVs) are multifaceted subcellular entities that may represent a new generation of bio-camouflaged drug/ nanoparticle delivery system and regenerative medicine effectors. In a top-down procedure…
- Oral · In-Person
Antibody-guided discovery of potent small-molecule fusion inhibitors of influenza virus
Maria van Dongen · Johnson & Johnson, Belgium
Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential new pandemics, emerging viruses, and constantly mutating circulating strains. We report here on discovery and…
- Oral · In-Person
Targeting liver function to circumvent neuronal and cardiac dysfunctions linked to hyperhomocysteinemia
Nathalie Janel · Universite Paris Diderot, France
Hyperhomocysteinemia is well recognized as an independent risk factor for cardiovascular diseases and is associated with diverse dysfunction. It’s the second most common amino acid metabolic disorder. If it is not…
- Oral · In-Person
Detection of “Hidden” drug resistance by the EZMTT assay
Benfang Helen Ruan · Zhejiang University of Technology, China
The EZMTT-based cell viability assay is a true continuous assay that may be used to generate cell growth curves easily and precisely under various conditions. Its sensitivity is 10-30 times better than that of the…
- Oral · In-Person
New indications for FDA-approved drugs: Selective inhibition of the growth of Helicobacter pylori by covalent allosteric regulation of urease
Fang Wu · Shanghai Jiao Tong University, China
To date, little attempt has been made to develop new treatments for Helicobacter pylori ( H. pylori ), although the community is aware of the shortage of treatments for H. pylori and the increase in drug resistance of…
- Oral · In-Person
Chimeric antigen receptor(CAR)-T CELL; a biodrug as cancer therapeutic agent
Preeti Sharma · Autonomous State Government Medical College, India
A class of fastest growing therapeutic agents, biodrugs are the complex molecules derived from living organism or its products, used in the prevention diagnosis and treatment of cancer or other diseases. These biodrugs…
- Oral · In-Person
Freshwater Sapropel as raw material in medicine and pharmaceutical production
Agris Auce · Rigas Stradins University, Latvia
Sapropel is natural remedy that has been applied externally via different topical applications or as a base for mud bath in skin care and health improvement procedures and can be classified as traditional remedy.…
- Oral · In-Person
P-selectin targeted nanocarriers are efficient drug delivery systems to activated endothelium
Manuela Calin · Institute of Cellular Biology and Pathology “N. Simionescu”,, Romania
Inflammation is a common process associated with numerous vascular pathologies. During the vascular inflammation process, endothelial cells (EC) express both the receptors for advanced glycation end products (RAGE) and…
- Oral · In-Person
: Development of novel leads for triple-negative breast cancer immunotherapy
Jing Yu · Shanghai Jiao Tong University, China
Breast cancer ranks first of all cancers among women in the world in incidence and mortality. It is still on the rise year by year. Triple negative breast cancer (TNBC) comprises around 15~20% of breast cancers. It is…
- Oral · In-Person
Screening of new peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1 as anti-inflammatory agents
Pasqualina Liana Scognamiglio · University of Naples “Federico II”, Italy
SOCS (Suppressor Of Cytokine Signalling) proteins are negative feedback regulators of the JAK (Janus kinase)/STAT (Signal Transducer And Activator Of Transcription) pathway. Their expression levels are low under…
- Oral · In-Person
Novel small molecules for PPARs modulation and their potential use for treatment of metabolic disorders
Antonio Laghezza · Università degli Studi di Bari “Aldo Moro”, Italy
Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated transcription factors that play a pivotal role in the regulation of glucose homeostasis and lipid metabolism and so they are considered as…
- Oral · In-Person
Caloric restriction and longevity
Bartolome Ribas Ozonas · Royal National Academy of Pharmacy, Spain
Caloric restriction (CR) in normal human bodies means to maintain a low-caloric diet, balanced in nutrients, vitamins and catalytic mineral ions (ca. 1750 Kcal/day), in order to benefit aging in good health, an active…
- Oral · In-Person
Synactix Inc and academic case studies of targeted therapy
Hong-yu Li · University of Arkansas for Medical Sciences, United States
Synactix Pharmaceuticals, Inc. is a biotechnology company established to help decrease the catastrophic burden cancer has placed on global health. Instead of looking at cancer as a whole, Synactix identifies unique…
- Oral · In-Person
Liposomal encapsulation of silver nanoparticles suppresses nanoparticle-induced ROS and inflammation, and induces caspase-dependent apoptosis
Azeez Yusuf · Technical University Dublin, Ireland
High concentrations of silver nanoparticles (AgNP) are increasingly present as active ingredient in everyday consumable products for antibacterial purposes causing increased human exposure and high risk of adverse…
- Oral · In-Person
Development of substances with biological and pharmacological activity based on structural nucleus hybrids from phytochemical compounds like secondary metabolites
José Eduardo Cuéllar · Universidad Nacional de Colombia, Colombia
The treatment of different diseases is currently associated with the pharmacokinetics of chemical substances which are supplied to certain patients where there are, for example, enzymatic inhibitions, and this is…
- Oral · In-Person
Aspects of controlled-release dosage forms in veterinary medicine with emphasis on GRDF (Gastro retentive dosage forms)
Eran Lavy · Hebrew University of Jerusalem, Israel
Early development of controlled-release drug delivery systems was aimed at serving the challenges of human medicine. Around the mid-1970s the technology of controlled-release dosage form (CRDF) was started to be applied…
- Oral · In-Person
The impact of inspiratory parameters on the performance of marketed dry powder inhalers using patients’ inhalation profiles
Mohamad Abadelah · University of Huddersfield, United Kingdom
Dry powder inhalers (DPIs) are passive devices used to administer inhaled medication for the management of asthma and chronic obstructive pulmonary disease (COPD). DPIs require patients to generate a sufficient internal…
Present your research at PDDS 2027
Abstract submissions for the 2027 program are open · September 13–15, 2027 · Olympia Hotel, Events & Spa, Valencia, Spain.
Join the PDDS 2027 delegation
Valencia · September 13–15, 2027 · Hybrid · in-person & virtual
Attend without presenting.