S-nitrosoglutathione (GSNO) is a physiological nitric oxide donor and a promising drug for several acute or chronic diseases (e.g. stroke, atherosclerosis, …). However, this nitrosated tripeptide is highly hydrophilic and easily degraded while exposed to oxygen, light, met [....] » Read More
Live-attenuated bacterial vectors for antigens delivery have aroused growing interest in the field of cancer immunotherapy. Their potency to stimulate innate immunity and to promote intracellular antigen delivery into antigen-presenting cells could be exploited to elicit a strong [....] » Read More
The scientific aspect of this research focuses upon the use of metals by antibodies in the mammalian adaptive immune system. It is estimated that one third of all proteins are metalloproteins. However, the use of metals by antibodies to recognize and bind to antigens is still som [....] » Read More
Modified nucleotides are present in several RNA species in all Domains of Life. While the biosynthetic pathways of these nucleotides were well studied in recent years, much less attention was drawn to the degradation of different RNAs and the return of modified nucleotides or the [....] » Read More
Actinic keratosis (AK) is a common skin disease characterized by cutaneous lesions in the sun-exposed areas of the skin; it is often asymptomatic, but if left untreated it may be the precursor of squamous cell carcinoma (SCC), a non- melanoma skin cancer. The treatment of early c [....] » Read More
Triple Negative Breast Cancers (TNBC) are not efficiently treated by specific targeted therapy. New strategies must be envisaged and nanocarriers appear as good candidates to overcome low efficacy of drugs or resistance to treatment. CD44 is found overexpressed in many tumors, su [....] » Read More
RNA interference (RNAi) is a mechanism in which small interfering RNA (siRNA) silences a target gene. Herein, we describe a DNA hydrogel capable of producing siRNA and interfering with protein expression. This RNAi-exhibiting gel (termed I-gel for interfering gel) consists of a p [....] » Read More
Background: Nanomedicine is an attractive and promising field that uses nanoparticles to serve as drug carriers. This field can improve the treatment of the complications of cardiovascular diseases including pulmonary arterial hypertension (PAH). PAH is an aggressi [....] » Read More
Medical device infection is one of the most problematic issues associated with implanted medical devices. More than 60% of nosocomial infections are related to a medical device, with treatment being particularly challenging. Pathogenesis of infection frequently involves formation [....] » Read More
Plasminogen activators (PAs), compounds that convert the blood plasminogen (Pg: inactive proenzyme) to plasmin (Pm: active enzyme) are used in the treatment of thrombotic disorders like myocardial infarction. Streptokinase (SK), the first and most utilized PA, is produced by grou [....] » Read More
Drug safety and pharmacovigilance remains a dynamic clinical and scientific discipline. Pharmacovigilance is defined by the World Health Organization (WHO) as ’the science and activities relating to the detection, assessment, understanding and prevention of adverse effects [....] » Read More
The report discusses the latest achievements of the authors in developing original methods for stereoselective synthesis of natural acetogenins, higher bis-methylene-separated(interrupted) di- and trienoic acids, lembehynes that are of interest as low-toxic target antitumor drugs [....] » Read More
Anthracyclines are one of the most commonly used and most effective chemotherapeutic agents in a wide variety of cancers. Their primary mechanism of action is through binding to DNA, which leads to inhibition of DNA synthesis, DNA damage and eventually apoptosis. Since they act p [....] » Read More
For those who works in the pharmaceutical sector knows that doing business globally is a challenge. The regulatory affairs profdessional needs to have a broadly view of the current trends such as risk management, pharmacovigilance, misleading, etc. &n [....] » Read More
Self-propelled objects have been studied as potential carriers to transport materials or themselves to a target location in a confined space, mimicking the behaviours of bacteria. Most self-propelled objects exhibit monotonous or random motion, since the direction of motion is de [....] » Read More
Cancer is the leading cause of death worldwide, accounting for 8.8 million deaths, with lung cancer attributing to 1.69million of these deaths in 2015. The application of natural products to treat various diseases, such as cancer, has been an important area of research for many y [....] » Read More
Supramolecular modification of active pharmaceutical ingredients (APIs) and new chemical entities (NCEs) to enhance their physicochemical properties and improve their delivery can be achieved via crystal engineering methods, which involve the generation of alternative, [....] » Read More
The interaction between intracellular caspase 9 and serine/threonine phosphatase PP2A proteins is critical to apoptosis. We have designed a Cell Penetrating and Interfering Peptide (CP and IP), Mut3DPT-C9, which specifically disrupt the interaction caspase 9/PP2A and evaluated it [....] » Read More
We reported that chiral all-organic rod-like liquid crystalline (LC) compounds with a five-membered cyclic nitroxide unit in the central core position exhibited the spin glass-like inhomogeneous ferromagnetic interactions in the LC phases at high temperatures under low magnetic f [....] » Read More
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking selectivity for IN tetramers [....] » Read More
The use of nanometric systems as disposal of biologically active substances is a successful tool in different areas of knowledge. In this research we studied nanometric systems with antioxidant capacity to modulate events associated with the redox state in human chondrocytes. We [....] » Read More
The biogenic synthesis of nanomaterials is considered an eco-friendly approach to nanomaterial synthesis that produces nanomaterials that is more biocompatible and therefore more suitable for biomedical applications. Several studies have shown the antibacterial properties of biog [....] » Read More
Abiraterone acetate (AA) is a poorly water-soluble drug molecule indicated for patients with metastatic castration resistant prostate cancer. It is a prodrug, which is converted to abiraterone in vivo. The oral dose is high; 1,000 mg which is administered once daily as 4x250 mg Z [....] » Read More
Aim of the work is to compare chosen biopolymers and critically evaluate their ability to provide of model drugs with different solubility. Chitosan and Alginate-natrium are natural derivates of cellulose that are sparingly used in many fields of industry like [....] » Read More
The liver plays an important role in regulating physiological functions such as detoxification of harmful substances. Liver injuries and diseases cause necrosis and apoptosis mainly due to an imbalance in cell protection pathway or detoxification. Therefore, liver injuries and di [....] » Read More
Hematopoietic stem/progenitor cell (HSPC) mobilization is an essential homeostatic process regulated by the interaction of cellular and molecular components in bone marrow niches. It has been shown by others that neurotransmitters released from the sympathetic nervous system regu [....] » Read More
Adeno-associated virus (AAV) is a promising vector for systemic delivery of siRNA due to its long-term expression ability without immunogenicity and pathogenicity. However, its broad host tropism and lack of tissue specificity has limited clinical applications such as cancer ther [....] » Read More
Asthma is a disease which occurs due to chronic inflammation in the airways. The most prominent clinical features of asthma are constriction and obstruction of the airway, which renders breathing difficult and complicated. Curcumin, a highly potent therapeutic substance, is obtai [....] » Read More
Background: Calotropis gigantea (CG), a tall and waxy flower that has been used in treating fever, indigestion, rheumatism, leprosy and leukoderma as traditional remedies. However, it has not yet been examined about the precise mechanisms of its anti-cancer effects in human [....] » Read More
The aim of this study was to evaluate the possibilities of using matrix tablets and dual matrix tablets containing hydrophilic and/or lipophilic retardant for extended release of pentoxifylline. Polyvinyl alcohol (Parteck® SRP 80) and hypromellose with different viscosi [....] » Read More
Rotigotine, a non-ergot dopamine agonist (D2-D5 receptors) drug used in the treatment of idiopathic Parkinson’s disease (PD). Presently, its clinical use is very limited due to its poor oral bioavailability. Thus, this study was designed to develop chitosan nanoparticles (C [....] » Read More
Alzheimer’s disease (AD) is characterized by a slow but progressive deterioration in cognitive performance. The decrease of acetylcholine (ACh) due to cholinergic neuronal dysfunction in the hippocampus and cortex could result in AD. Current clinical therapy for AD patients [....] » Read More
The aim of our project is to develop innovative tumor-specific approaches for transport of bioactive compounds in tumor cells for targeted therapy in cancer. Tumor Penetrating Peptides (TPP) are a subclass of tumor homing peptides that penetrate extravascular tumor tissue and spe [....] » Read More
Sapropel is organic sediment that accumulates underwater in shallow to deep marine basins, lagoons and lakes. The sapropel forms by slow decomposition process of phytoplankton, waste material from higher plants and aquatic animals and fine-grained nonorganic particles in the sedi [....] » Read More
Ascorbic acid AA (vitamin C) has been widely used in the cosmetic field as an anti-wrinkle agent due to a variety of biological, pharmaceutical and dermatological functions. The main cause of aging is a decline in vitamin C content as a result of chronological aging and photoagin [....] » Read More
Conventional organogel and nanoemulsion–laden organogels (nanoemulsion organogels) were used to deliver the lipophilic drug, lidocaine, topically. Optimized formulations of lidocaine–loaded nanoemulsions of oil, water, and different ratios of surfactant to cosurfactan [....] » Read More
Tuberatolide B (TTB, C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of TTB remain unknown. In this study, we demonstrate that TTB inhibits tumor growth in breast, lung, colon, prostate, [....] » Read More
Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can develop. Therefore, effective treatment before chronic inflammation [....] » Read More
Saringosterol acetate (SSA) can be isolated from an edible brown alga, Hizikia fusiforme. In this study, we developed an adult zebrafish human hepatocellular carcinoma (HCC) xenograft model to confirm our previous finding that SSA inhibits tumor growth and metastasis. The ze [....] » Read More
Advanced polymer chromatography (APC) is a size exclusion chromatography (SEC) designed by Waters for fast, efficient, and robust polymer characterization. The molecular weight (Mw) separation range is from 100 Da to 2 000 kDa and quick switch from one solvent to another solvent [....] » Read More
The diagnosis of Alzheimer's disease (AD), a neurodegenerative disease that affects cognitive functions, remains difficult and the first noticeable symptoms, as well as the detection of current biomarkers, means that brain lesions have already occurred and often for several y [....] » Read More
The unique optical properties of gold nanoparticles (AuNP) can facilitate the development of ultrasensitive imaging-based therapeutic systems. Several studies have demonstrated the application of AuNPs for targeted drug delivery and photothermal therapy (PTT). Consequently, a num [....] » Read More
Pseudomonas aeruginosa is an opportunistic bacterium and is the second-leading cause of nosocomial infections and pneumonia in hospitals, which are mainly acquired in intensive care units. The pathogen is also responsible for the chronic colonization of the respiratory tract that [....] » Read More
The administration of drugs through the ocular topical route supposes a considerable reduction of its bioavailability (naso-lacrimal drainage, protection mechanisms of the eye such as blinking and loss towards systemic circulation), which translates into a short therapeutic effec [....] » Read More
Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential new pandemics, emerging viruses, and constantly mutating circulating strains. We report here on discovery and structural characterization of potent peptidic and non-peptidic s [....] » Read More
Hyperhomocysteinemia is well recognized as an independent risk factor for cardiovascular diseases and is associated with diverse dysfunction. It’s the second most common amino acid metabolic disorder. If it is not treated, the life expectancy of these patients is greatly re [....] » Read More
The EZMTT-based cell viability assay is a true continuous assay that may be used to generate cell growth curves easily and precisely under various conditions. Its sensitivity is 10-30 times better than that of the bacterial turbidity assay, so that minor drug resistance can [....] » Read More
To date, little attempt has been made to develop new treatments for Helicobacter pylori (H. pylori), although the community is aware of the shortage of treatments for H. pylori and the increase in drug resistance of gram-negative bacteria. Thus, there is an un [....] » Read More
A class of fastest growing therapeutic agents, biodrugs are the complex molecules derived from living organism or its products, used in the prevention diagnosis and treatment of cancer or other diseases. These biodrugs include a vast variety of molecules including antibodies, cel [....] » Read More
Sapropel is natural remedy that has been applied externally via different topical applications or as a base for mud bath in skin care and health improvement procedures and can be classified as traditional remedy. Sapropel forms over long period of time in shallow waters by slowly [....] » Read More
Inflammation is a common process associated with numerous vascular pathologies. During the vascular inflammation process, endothelial cells (EC) express both the receptors for advanced glycation end products (RAGE) and the cell adhesion molecule P-selectin that initiate and perpe [....] » Read More
Breast cancer ranks first of all cancers among women in the world in incidence and mortality. It is still on the rise year by year. Triple negative breast cancer (TNBC) comprises around 15~20% of breast cancers. It is characterized by a poor prognosis, high rates of proliferation [....] » Read More
SOCS (Suppressor Of Cytokine Signalling) proteins are negative feedback regulators of the JAK (Janus kinase)/STAT (Signal Transducer And Activator Of Transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to c [....] » Read More
Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated transcription factors that play a pivotal role in the regulation of glucose homeostasis and lipid metabolism and so they are considered as suitable targets for the treatment of metabolic disorders. These rec [....] » Read More
Caloric restriction (CR) in normal human bodies means to maintain a low-caloric diet, balanced in nutrients, vitamins and catalytic mineral ions (ca. 1750 Kcal/day), in order to benefit aging in good health, an active longevity preventing emerging diseases, and avoiding not genet [....] » Read More
Synactix Pharmaceuticals, Inc. is a biotechnology company established to help decrease the catastrophic burden cancer has placed on global health. Instead of looking at cancer as a whole, Synactix identifies unique, malignant pathways that are amenable to therapeutic interv [....] » Read More
High concentrations of silver nanoparticles (AgNP) are increasingly present as active ingredient in everyday consumable products for antibacterial purposes causing increased human exposure and high risk of adverse effect development. In this study, AgNP were encapsulated dipalmit [....] » Read More
The treatment of different diseases is currently associated with the pharmacokinetics of chemical substances which are supplied to certain patients where there are, for example, enzymatic inhibitions, and this is directly related to the molecules interactions presents in the huma [....] » Read More
Early development of controlled-release drug delivery systems was aimed at serving the challenges of human medicine. Around the mid-1970s the technology of controlled-release dosage form (CRDF) was started to be applied for veterinary medicine purposes. The de [....] » Read More
Dry powder inhalers (DPIs) are passive devices used to administer inhaled medication for the management of asthma and chronic obstructive pulmonary disease (COPD). DPIs require patients to generate a sufficient internal turbulent airflow force during each inhalation to deaggregat [....] » Read More
PepFect delivery technology for oligonucleotide transfection by transportan based cell-penetrating peptides in vitro and in vivo is described. Recent data on mechanisms and applications of PepFect strategies are summarized on the variety of different cargoes i [....] » Read More
The respiratory route has been used to deliver drugs into the human body for centuries. However, the airways and lungs have a complex physio-anatomical architecture, thus making drug delivery to the lungs more challenging and most current inhalers still suffer from poor drug deli [....] » Read More
After its astonishing and unexpected discovery in 2004, graphene, a two-dimensional nanomaterial made of single-layered carbon molecules organized in a honeycomb cross section, has been broadly investigated for an incredible number of uses including quantum material science, nano [....] » Read More
Extracellular vesicles (EVs) are multifaceted subcellular entities that may represent a new generation of bio-camouflaged drug/ nanoparticle delivery system and regenerative medicine effectors. In a top-down procedure, our group has engineered nanoparticle/drug-loaded EVs from pr [....] » Read More
Title : Docetaxel-liposomes prepared by the dual centrifugation method: Effect of propylene glycol and lipid charge on liposomal characteristics
Ann Mari Holsaeter, The Arctic University of Norway, Norway
Docetaxel (Doc) is a highly lipophilic anticancer drug. The current Doc treatment gives several side effects that might be prevented when Doc is incorporated in liposomes. The first aim of this study was to adapt the Dual Centrifugation (DC) method as a preparation technique for [....] » Read More
Title : Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments
Jan Tavernier, Ghent University, Belgium
An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as these are only available in a lim [....] » Read More
Title : Lipid and carbohydrate based delivery vesicles for gene therapeutics: Approaching difficult diseases
Kira Astakhova, University of Southern Denmark, Denmark
RNA therapeutics is a broad group of RNA oligo- and polymers that knock down, insert or replace a disease associated RNA. RNA therapeutics act via diverse biological mechanisms including e.g. antisense oligonucleotides (ASOs), RNA interference oligonucleotides, mRNAs and sgRNA/CR [....] » Read More
Title : In vitro modeling of the blood-brain barrier to assess CNS drug delivery
Fabien Gosselet, Blood-brain barrier laboratory, Artois University, France
The blood-brain barrier (BBB) is located at the brain microvessel level and isolates the brain from the whole body, thus restricting molecule and cell exchanges between cerebral and peripheral compartments. BBB physiology is altered in Alzheimer’s disease (AD) mainly charac [....] » Read More
Title : Prototyping and evaluating a novel humanoid chewing robot for drug delivery using a medicated chewing gum
Kazem Alemzadeh, University of Bristol, United Kingdom
The global pharmaceutical market in 2009 was estimated at $837 billion and the US had a largest market share worth $300 billion per annum. It is estimated that the market could be worth nearly $1.6 trillion by 2020. The global drug delivery market in 2016 was estimated to be wort [....] » Read More
Title : Multifunctionalized and targeted biocatalytic nanoreactor for combinatory treatment of ER+ breast cancer
Rafael Vazquez-Duhalt, Universidad Nacional Autónoma de México, Mexico
Background: Tamoxifen is the standard endocrine therapy for breast cancers, which require metabolic activation by cytochrome P450 enzymes (CYP). However, the lower and variable concentrations of CYP activity at the tumor remain major bottlenecks for the efficient treatment, [....] » Read More
Title : New approach to study difference in NSAIDs enantiomer activity, including chiral inversion
Tatyana V. Leshina, Voevodsky Institute of Chemichal Kinetics and Combustion SB RAS, Russian Federation
The difference in the medical properties of the enantiomers of many chiral drugs is a well-known fact. This is a big problem, since most drugs are still used in the form of racemates. The latter is connected with the difficulties of separation. One of the most prominent represent [....] » Read More
Title : In situ delivery and production system of anti-cancer molecules with gene-engineered bifidobacterium
Shun’ichiro Taniguchi, Shinshu University School of Medicine, Japan
Regardless of recent rapid progresses in cancer therapy by molecular-targeting and regulating immune check points, the side effects of those treatments are still troublesome for the patients to be overcome. We have developed an in situ Drug Delivery and Production [....] » Read More
Title : Influence of mucoadhesivity on the bioavailability of nanoparticulate drug delivery systems
Ylenia Zambito, University of Pisa, Italy
The oral administration route is by far the preferred one and more than 80% of drugs are taken orally. Since the gastrointestinal (GI) tract is the primary site of drug delivery, many researchers have focused their attention on the mucus layer that covers the GI tract. Indeed, th [....] » Read More
Title : Systemic liver-targeting delivery of a novel DNA/RNA heteroduplex oligonucleotide via an enteral route
Chie Watanabe, Josai University, Japan
Since the advent of antisense technology, oligonucleotide drugs have attracted a greater deal of attention as next-generation therapeutics, which can be selectively delivered to their target tissue to obtain effective gene silencing. The production of conventional pharmaceutical [....] » Read More
Title : Physicochemical and biophysical study of mechanisms the drugs bioavailability enhancement with new multifunctional delivery systems
Nikolay E. Polyakov, Voevodsky Institute of Chemical Kinetics and Combustion, Russian Federation
One of the most important problems of modern pharmaceutics is the low solubility and bioavailability of drug compounds. These problems are solved by using various delivery systems that can form water-soluble “guest-host” complexes with drug molecules. One of the advan [....] » Read More
Title : Designing ADME formulations with matching exposures to amorphous solid dosage forms
Aditya Tatavart, Merck Sharp & Dohme Inc, United States
Amorphous solid dispersion (ASD) based formulations have been frequently used to improve the bioavailability of poorly soluble drugs. However, common processes to produce ASDs are not feasible for absorption, distribution, metabolism and excretion (ADME) studies with radio-labele [....] » Read More
Title : Wound healing mats made of layer by layer coated nanoparticles and electrospun nanofibers
Gulcin Arslan Azizoglu, Ege University, Turkey
Introduction: A broad range of diseases could be altered using layer-by-layer (LbL) based nanoparticles which is an emerging and powerful method to develop multifunctional nanomedicines. In this study, a combined formulation was achieved with LbL coating of silver nanosphere [....] » Read More
Title : In vitro model of diclofenac sodium gel delivery through pig skin
Enkelejda Goci, Aldent University, Albania
At first sight transdermal drug delivery appears to be a simple form of treatment, but closer examination reveals that dermatological form doses represent one of the most difficult aspects of the science of pharmaceutical formulation. Modern formulation methods nowadays, however, [....] » Read More
Title : Influence of formulation and freeze drying process variations on protein stability
Paritosh Pande, IMA Life North America and University of Connecticut, United States
Nearly half of the therapeutic proteins undergo freeze drying process to improve their long-term storage stability but the inability to directly control the product temperature during freeze-drying process can lead to non-uniform distribution of critical quality attributes (CQAs) [....] » Read More
Title : Valproic acid encapsulated biodegradable microneedles for treatment of androgenetic alopecia
Shayan Fakhraei Lahiji, Yonsei University, Korea, Republic of
There are numerous genetic and environmental factors responsible for occurrence of male pattern hair loss known as androgenetic alopecia. Despite considerable medical advancements, the current treating agents, are limited by unsatisfactory cure rate and potential side effects. Va [....] » Read More
Title : Therapeutic effects of trehalose liposomes against tumors along with apoptosis
Yoko Matsumoto, Sojo University, Japan
Trehalose stabilizes membranes and proteins in cells most likely by hydrogen bonding. Trehalose liposomes (DMTre) composed of L-α-dimyristoylphosphatidylcholine (DMPC) and trehalose micelles (TreC14) have been produced by sonication of a mixture of DMPC and TreC14 in [....] » Read More
Title : Novel developments in lipid-based multifunctional combination nanopreparations for multidrug resistant cancer
Vladimir P. Torchilin, Northeastern University, United States
Therapy of multidrug resistant cancers could be significantly enhanced by using siRNA down-regulating the production of proteins involved in cancer cell resistance, such as Pgp or survivin. Even better response could be achieved is such siRNA could be delivered to tumors together [....] » Read More
Title : Taking your active from the lab to scale-up formulation development of a topical delivery systems
Robert Houlden, Formulytica Pty. Ltd, Australia
The presentation will discuss (with practical examples) the steps required to take a pharmaceutical active from the research lab to developing a topical oil-in-water vehicle or gel for drug delivery. Preformulation steps such as methods to increase solubility and skin penetration [....] » Read More
Title : Government and industry response to the US opioid epidemic
Robert P. Bianchi, Prescription Drug Research Center, United States
Prescription drug abuse has been declared an epidemic in America by the Centers for Disease Control and Prevention and the president of the United States which makes up 4.6 percent of the world’s populations but consumes 81 percent of the world supply of oxycodone. The FDA [....] » Read More
Title : The use of self-immolative polymers to control cellular delivery
Georgina Kate Such, The University of Melbourne, Australia
Nanoparticles are of interest for the delivery of therapeutics as they are capable of targeting drug release specifically to diseased cells and tissue. Self-assembled polymeric carriers have generated particular attention for drug delivery applications due to their simple and ver [....] » Read More