Hong-yu Li is a Professor of Medicinal Chemistry at the University of Arkansas for Medical Sciences (UAMS). He is also an Arkansas Research Alliance (ARA) Scholar, the Helen Adams & ARA endowed chair in drug discovery, and co-director for the Therapeutics Science Program, Winthrop P Rockefeller Cancer Institute. He received his Ph.D. degree from the University of Tokyo and did postdoctoral training at Columbia University and Harvard University. He previously worked at Eli Lilly and the University of Arizona where he focused on oncology drug discovery. His current research interests are in chemical biology and drug discovery, especially for oncology related targets and phenotypes. In his lab at UAMS, a robust oncology pipeline is under development exploiting single agent polypharmacology and synergistic medicinal chemistry approaches.