Speaker at Global conference on Pharmaceutics and Drug Delivery Systems 2019 - Preeti Sharma
Autonomous State Government Medical College, India
Title : Chimeric antigen receptor(CAR)-T CELL; a biodrug as cancer therapeutic agent


A class of fastest growing therapeutic agents, biodrugs are the complex molecules derived from living organism or its products, used in the prevention diagnosis and treatment of cancer or other diseases. These biodrugs include a vast variety of molecules including antibodies, cells, interleukins, vaccines and various proteins. The therapeutic molecules have revolutionized the treatment of many serious and chronic illnesses and have nudged the traditional drugs. Rheumatic arthritis, certain cancers, and diabetes are the diseases having greatest number of dedicated biologic treatment drugs.
    Crossing through threshold in clinical activity, chimeric antigen receptor modified T cells have emerged as a new effective therapeutic regimen against various types of cancer both in adults and pediatric oncology. Currently available CARs are designed in a manner so as to be capable of MHC independent antigen recognition and incorporate costimulatory signal, converting the transduced T cells with potent T cell activity. There are three generations of CAR-T cells depending upon intracellular signalling domain number. They have higher efficacy than monoclonal antibody and antibody-drug conjugate. CAR therapy maintained especial status as cancer immunotherapeutic agent, after targeting the CD19 cell surface molecules expressed in a various types of cancers and, successfully transforming in clinic practice. Standing on the pillars of genetic engineering, T cell biology, molecular biology, tumor biology, target identification, CAR-T therapy holds great promise as off the shelf cancer therapeutic agent. But several unresolved concerns are still prevailing. Various issues with regard to safety, efficacy and their preparation, quality control issues, are still stucking the way. Cytokine release syndrome, neurological toxicities are few major side effects of the therapy blocking the successful development of CAR-T cells in the clinical trials. Our presentation shall be dealing with structural aspects of CAR T cells, target and signalling, their toxicity perspectives and current status.
Audience take away:
• In the present lecture an extensive analysis of one of the most efficient anticancer biodrug, the chimeric antigen receptors and its  current status has been done. From this we can surely gain insight into the successful strategies so far available to bring this innovative biodrug in the market. 
• Well many challenges still persist for the researchers working in the area. The way is not likely to be straightforward due to on /off tumor targeting and toxicity and hostile microenvironment of the cancer cells leading to less efficacious response. Cost and complexity of these  product is another issue to be taken into consideration to further execute the studies in this direction to come up with the solution.


Motivating and talented Biochemistry Professor, driven to inspire students to pursue academic and personal excellence. Consistently strive to create a challenging and engaging learning environment in which students become lifelong learners. Exceptional track record of research success with multiple published articles. Dr. Preeti Sharma is currently working in the Department of Biochemistry, Autonomous State Government Medical College, Uttar Pradesh, India, deeply involved in teaching and research. Her area of research has been interdisciplinary including Drug Metabolism, Pharmacokinetics and Inflammatory Markers, and Immunology.  She has more than 135 publications (research and review articles) with high citations and few in the phase of communications. She also wrote 2 books on Bio-organic Chemistry and the Basics of Immunology. She is a member of various professional bodies and has participated and presented a number of papers in national and international conferences.  She is frequently invited as an international speaker and currently, she is a global cooperative research consultant. She is credited with a number of ICMR (Indian Council of Medical Research)-STS-funded projects and has guided and co-guided a number of Ph.D. and MD students in the field of Medical Biochemistry. She is awarded the International Scientist Award in 2020 and the research excellence award in 2021, the International education award in 2021 for his exceptional contribution to research & teaching respectively. During the pandemic, she has been deeply involved in covid related research. Her contributions to covid-19 research in published in various publications and recently she was awarded the Uttar Pradesh​​​​​​ Government DGME corona worrier award 2022.