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Speaker at Pharma Conferences - Eran Lavy
Hebrew University of Jerusalem, Israel
Title : Aspects of controlled-release dosage forms in veterinary medicine with emphasis on GRDF (Gastro retentive dosage forms)


Early development of controlled-release drug delivery systems was aimed at serving the challenges of human medicine. Around the mid-1970s the technology of controlled-release dosage form (CRDF) was started to be applied for veterinary medicine purposes. 
   The development of CRDF is highly desirable, both from a convenience and a compliance perspective. One of the biggest advantages of such formulations over the conventional ones is the ability to release a drug at a pre-prescribed rate, leading to relatively constant and stable serum concentrations. Another benefit is the ability to administer medications in infrequent. The use of CRDFs reduces adverse affects and thereby assists in optimizing therapy. 
During recent years our team developed and evaluated several kinds of CRDFs based on a drug delivery system producing a polymeric matrix for various indications in animals.
    These include parenteral controlled release antibiotic formulation model in goats, pigs, calves, dogs, pigeons, and parrots; a topical sustained release varnish for treatment of dental disorders in dogs and kangaroos, a topical sustained release formulation for udder health in dairy cows, gastro-retentive dosage form (GRDF) in dogs, and coated catheters with a sustained release varnish for prevention of urinary tract infections in dogs. In many of these trials, we achieved the ability to provide a constant serum drug level that is higher than the MIC for several days, by using a single administration.
   In conclusion, it appears to be an enormous potential for controlled release drugs for many indications in various species of animals.


Eran Lavy is an Associate Professor for Veterinary Medicine at the Koret School of Veterinary Medicine Robert H. Smith Faculty of Agriculture, Food and Environment of the Hebrew University of Jerusalem (HUJI). He received BSc. in agriculture (animal husbandry) HUJI at 1984, MSc. in pharmaceutical sciences HUJI at 1986 and his DVM degree HUJI at 1989. He was certified as specialist in clinical medicine of companion animals by the Israeli Veterinary Services at 1995 and as specialist in veterinary pharmacology by the Israeli Veterinary Services at 1997. He was certified as specialist Diplomate in Veterinary Pharmacology and Toxicology (Dip. ECVPT), by the European College of Veterinary Pharmacology and Toxicology at 1999. Since 1989 he is a faculty member at the HUJI and is working at the Hebrew University Teaching Hospital in the Internal Medicine Department with special interest in gastroenterology. His research interests are mainly in clinical pharmacology especially aspects related to controlled release drug delivery systems (CRDDS). Since 2011 He is Associate Professor in Veterinary Medicine. He is teaching in several Veterinary Medicine courses. Professor Lavy supervised M.Sc., Ph.D. and final DVM thesis students, published over 60 scientific papers and hold 8 patents in the field of CRDDS. He is a member of several comities at the Veterinary Medicine School as well as the Agriculture Faculty and several organizations around the world.