Title : Aspects of controlled-release dosage forms in veterinary medicine with emphasis on GRDF (Gastro retentive dosage forms)
Early development of controlled-release drug delivery systems was aimed at serving the challenges of human medicine. Around the mid-1970s the technology of controlled-release dosage form (CRDF) was started to be applied for veterinary medicine purposes.
The development of CRDF is highly desirable, both from a convenience and a compliance perspective. One of the biggest advantages of such formulations over the conventional ones is the ability to release a drug at a pre-prescribed rate, leading to relatively constant and stable serum concentrations. Another benefit is the ability to administer medications in infrequent. The use of CRDFs reduces adverse affects and thereby assists in optimizing therapy.
During recent years our team developed and evaluated several kinds of CRDFs based on a drug delivery system producing a polymeric matrix for various indications in animals.
These include parenteral controlled release antibiotic formulation model in goats, pigs, calves, dogs, pigeons, and parrots; a topical sustained release varnish for treatment of dental disorders in dogs and kangaroos, a topical sustained release formulation for udder health in dairy cows, gastro-retentive dosage form (GRDF) in dogs, and coated catheters with a sustained release varnish for prevention of urinary tract infections in dogs. In many of these trials, we achieved the ability to provide a constant serum drug level that is higher than the MIC for several days, by using a single administration.
In conclusion, it appears to be an enormous potential for controlled release drugs for many indications in various species of animals.