Biography:
Dr. Mamuka Kvaratskhelia began his independent research career at the Ohio State University in 2003 and his research has been focused on better understanding of the structure and function of HIV-1 integrase as a therapeutic target. He has recently (2017) moved to University of Colorado Denver as a Professor of Medicine (Infectious Diseases) to further extend his studies on HIV-1 integrase. By employing innovative biochemical, biophysical, structural biology, molecular biology and virology approaches, his research team has made many important contributions to the field, which include the discovery of second, non-catalytic role of integrase in HIV-1 biology and elucidating the mode of action of allosteric HIV-1 integrase inhibitors (ALLINIs), which are currently in pre-clinical trials.
Title : HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors