Twenty two RNA therapies reached the medical market by Q1 2023. Targeted intracellular delivery remains the key requirement. For refinements of nanocarriers we focus on a bioinspired, sequence-defined process including (i) artificial amino acids (ii) precise assembly into xenopep [....] » Read More
Nanomaterials have been widely tested in vitro and in small-order animal studies for decades. Results have shown greater tissue growth, decreased bacteria growth, and inhibited inflammation. However, few studies exist examining human tissue response to nanomaterials. This present [....] » Read More
The necessity of new systems for drug delivery in children is due to the difficulty of the correct dose administration when the drug carrier is not easy to administrate. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in th [....] » Read More
Novel Quantitative Structure-Activity Relationship (QSAR) models of compounds’ placenta (PL) permeability expressed as their: i) log FM (fetus-to-mother blood concentration) values; ii) Clearance Index (CI); iii) binary PL1/0 (crossing/non-crossing; Yes/No) score were gener [....] » Read More
It is known that several microRNAs (miRNAs) have an important regulatory role during the different stages of atheroma plaque formation. In preclinical studies, the regulation of its expression has been shown beneficial outputs in the treatment of atherosclerosis. Thus, the therap [....] » Read More
Diabetes mellitus represents a large-scale health concern and has become a distressing hazard in the modern epoch of compromised lifestyles. So, there is an imperative need for screening and developing new pharmacologically active compounds that can meet still existing insufficie [....] » Read More
Tetracyclines (TC) are a class of broad-spectrum antibiotics widely employed to treat various human and animal bacterial infections. Due to their incomplete adsorption and partial metabolization by humans and animals, more than 70% of the TC used for pharmacological treatment are [....] » Read More
The text reviews a health issue through its epidemiological scope; Points out: chemical structure, synthesis, and mechanisms of action; It discusses its potency and speed of action, forms of administration and interaction with other drugs; Instructs on medical use; It recommend [....] » Read More
Background: Cancer is a major cause of morbidity and mortality worldwide. Small heterocyclic molecules are promising anti-cancer molecules. Imidazoquinoxaline derivatives induce apoptosis in colon cancer cell line HCT-116 and Breast cancer cell line MDA-MB-231. Aim: Investigat [....] » Read More
Chemotherapy has remained the mainstay for the treatment of multiple types of cancers. In particular, topical use of chemotherapy has been used for skin cancers. Though effective, topical chemotherapy has been limited due to adverse effects such as local and even systemic toxicit [....] » Read More
Cytokine storm has recently been recognized as the key pathology responsible for the severe symptoms of Covid-19 and other viruses and non-viral agents. The underlying biochemical cause of cytokine storms is excessive oxidative stress. Cytokine storm and its associated oxidative [....] » Read More
Peptide-based therapeutics, in the current biopharmaceutical market, are majorly available as parenteral formulations. Inherent physicochemical properties of peptides including hydrophilicity, bulky size, enzymatic degradation, and stress-induced denaturation make their delivery [....] » Read More
Based on the current and future market trends, liposome-based drug delivery systems is expected to have a phenomenal market size of 10 billion US dollars by the year 2035. The market potential has culminated in the synthesis and characterization of several liposomal product [....] » Read More
Background: Coronaviruses are a family of viruses that can cause illnesses such as the common cold, Fever, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Cancer, Asthma etc.Respiratory infection (RTI) is a viral spreading disease and it transmi [....] » Read More
While AI technologies are rapidly developing in medicine, their implementation in daily care is not yet a reality and we should not be overwhelmed by the challenges we face, but instead use resources to develop AI concepts in pharmacogenomic therapies, to make them safer and more [....] » Read More
Cancer remains a global public health concern due to its morbidity and mortality, and anticancer agents are crucial for the control and eradication of cancers. According to the International Agency for Research on Cancer. Although cancer chemotherapy has progressed in major strid [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Pharmaceutical waste constitutes a significant environmental challenge, with millions of dollars worth of unused medications being discarded annually. The mismanagement of pharmaceutical waste not only poses a critical ecological problem but also imposes a substantial global econ [....] » Read More
Hepatitis B, a viral infection that can cause both acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma, is a major global health issue. Hepatocellular carcinoma is one of the most common types of cancer, accounting for roughly 90% of all primary liver tumours. &nb [....] » Read More
Background: Accumulated evidence has emerged on the role of stem cells in key cellular functions such as their implication in host immune response and tissue regeneration. Currently, Mesenchymal Stromal Cells (MSCs), which are multipotent stem cells, have been used in a grea [....] » Read More
Title : New approach to hyponatremia yields high prevalence and identification of natriuretic protein that causes renal salt wasting (RSW) and new syndrome of RSW in alzheimer’s disease
John K Maesaka, NYU Long Island School of Medicine, United States
The approach to hyponatremia is in a state of flux, especially in differentiating the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from cerebral-renal salt wasting (RSW) because of diametrically opposite therapeutic goals of water-restricting in SIADH and a [....] » Read More
Title : Synergism in the permeability of the blood Brain barrier between heavy metals and electromagnetic fields
Bartolome Ribas Ozonas, Royal National Academy of Pharmacy, Spain
The blood-brain barrier protects the brain from certain ions, molecules and medicaments from their action and toxicity like the clouds in the earth's biosphere and its climate. Our thoughts induce neuron stimulation through synaptic activity, chemical reactions, electron move [....] » Read More
Title : Manufacturing outlook on cell and Gene and aseptic processing according the EU GMP Annex 1
Richard Denk, SKAN AG, Switzerland
The new EU GMP Annex 1 for sterile Manufacturing was published in August 2022. The industry does now have one year's time for implementation. Exception loading and unloading for the Lyophilization which provides an implementation time of two years. What does this mean for ste [....] » Read More
Title : Multi-detection of pharmaceutical contamination in environment
Andreia Freitas, INIAV and REQUIMTE, Portugal
The constant release of veterinary and human pharmaceutical drugs as active compounds or metabolites to the environment can result in the presence of undesirable contaminants in the ecosystems. Such anthropogenic contaminants can be discharged into the environment through wastewa [....] » Read More
Title : The role of non-antibiotic drugs on the development of antibiotic resistance
Mujde Eryilmaz, Ankara University, Turkey
Antibiotics are essential and versatile drugs due to the necessity of their use in cases such as surgical procedures, organ transplantations, and the treatment of cancer patients. However, due to the increasing rates of antibiotic resistance in recent years, there has been a fail [....] » Read More
Title : Digital health: Education in clinical pharmacy and implementation in practice
Aysu selcuk, Ankara University, Turkey
The outbreak of coronavirus disease 2019 increased the use of technology, especially in the healthcare sector, which experienced enormous pressures to provide for patients’ health needs. Due to the outbreak measures such as physical distancing or self-isolation, many patien [....] » Read More
Title : Novel glutatione based formulations for targeting the NLRP3 inflammasome in the treatment of cardiovascular diseases
Wayne Kaesemeyer, Augusta Hypertension PC, United States
This presentation will focus on the NLRP3 inflammasome and its involvement in the pathogenesis of cardiovascular diseases, the causes of its activation, and approaches to targeting these causes based on an extrapolation of the mechanism for preventing nitroglycerin tolerance usin [....] » Read More
Title : Pharmacovigilance – Important, current trends, challenges and opportunities
Gurpreet Singh, Freyr Lifesciences Limited, United Kingdom
Pharmacovigilance is the Detection, Assessment, Understanding and Prevention of Adverse Events associates with Drugs. Over the last 2 decades there has been an increased focus on Pharmacovigilance in order to ensure Patient Safety. The Health Authority requirements for a Marketin [....] » Read More
Title : Maternal, fetal and neonatal outcomes for women exposure during pregnancy to COVID-19 vaccines
Liberata Sportiello, University of Campania “L. Vanvitelli”, Italy
Although the European Medicines Agency (EMA) encourages coronavirus disease 2019 (COVID-19) vaccination in pregnant women, the scientific evidence supporting the use of COVID-19 vaccines during pregnancy is still limited. Thus, we investigated adverse events following immunizatio [....] » Read More
Title : Synergy of antioxidant and drug delivery abilities of glycyrrhizin
Nikolay E. Polyakov, Voevodsky Institute of Chemical Kinetics and Combustion, Russian Federation
Electron transfer plays a critical role in the generation of reactive oxygen species (ROS) in living systems. Molecular oxygen acts as a terminal electron acceptor in the respiratory chains of aerobic organisms, as well as in some photoinduced processes with subsequent formation [....] » Read More
Title : Intellection of molecular drug delivery models - An ayurvedic perspective
Ashtavaidyan Dr. E.T. Krishnan Mooss, Vaidyaratnam Group, India
Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several drugs have been developed and practiced from Ayurveda since ancient times to modern practice as ‘tradition to trend’. Charaka Samhita, Sushruta Samhita (~400 BC–200 [....] » Read More
Title : Biotechnological exploration of phyto-drugs against MDR bacteria targeting DNA topoisomerase I and RNA polymerase
Asit Kumar Chakraborty, Vidyasagar University, India
Alpha and Delta coronaviruses spread worldwide claiming >634000 lives and secondary multidrug-resistant infections were found a risk factor specifically in ICU patients containing carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecium and Kl [....] » Read More
Title : Chemo-enzymatic approach to synthesis of modified nucleosides
Rajesh Kumar, B.R.A. Bihar University, India
Over two decades, a large number of nucleosides have been synthesized, which demonstrated potent antiviral and antitumor activities and have become cornerstones of treatment for patients with cancer or viral infections. Oligonucleotide-based antisense strategies represent a uniqu [....] » Read More
Title : Investigating the effect of liposomal membrane rigidity on the permeability of doxorubicin
Eman Ramadan Abbase, Helwan University, Egypt
The permeability of the liposomal membrane is an important factor in determining whether drugs encapsulated inside liposomes are released. Many studies revealed the role of thermotropic phase, saturation degree and acyl chain length for the permeability of the liposomal membrane. [....] » Read More
Title : Design, synthesis of some novel chromen derivatives and evaluation of their effectiveness as the inhibitors of SARS-CoV-2 virus 3CL protease enzyme
Kalirajan Rajagopal, JSS college of pharmacy, India
Since 2020, COVID?19 has created a major threat to the human population across the globe. There are many mutations in SARS CoV-2 like Alpha, Beta, Delta and Omicron, etc. A newly emerged SARS-CoV-2 variant B.1.1.529 has worried health policymakers worldwide due to the presence of [....] » Read More
Title : Emerging formulation and delivery applications of Vitamin E TPGS
Andreas M Papas, College of Medicine, East Tennessee State University and Antares Health Products, Inc., United States
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glyco [....] » Read More
Title : Further studies on a new family of Antibiotics produced by Cryptic biosynthesis in Extremophilic Fungi
Andrea Stierle, University of Montana, United States
According to the CDC, at least two million people are infected with antibiotic-resistant bacteria every year, and over 35,000 die annually as a direct result of these infections. The Infectious Disease Society of America published a policy report that outlined the consequences of [....] » Read More
Title : The role of plants in modern drug discovery and screening
Ali Yetgin, Institute of Nature and Applied Sciences, Department of Biotechnology, Adana, Turkey, Turkey
Plants have played a pivotal role in the realm of contemporary drug discovery and screening, serving as a vast source of diverse and bioactive compounds. The present study thoroughly examines the multifarious contributions of plants to the progression of pharmaceutical research a [....] » Read More
Title : Prescription of potentially inappropriate medicines and comparison with lists of essential medicines for treatment of chronic disorders in older patients
Juan Gu, Affiliated Hospital of Zunyi Medical University, China
Short Description of what will be discussed during the presentation (about 250 - 500 words)My presentation will be divided into three parts. Firstly, I aim to introduce the background of potentially inappropriate medicines and highlight the pertinent problem that requires resolut [....] » Read More
Title : Preparation of uniform hyaluronic acid nanoparticles for biomedical applications
Nikola Matejkova, University of Pardubice, Czech Republic
Hyaluronic acid (HA) is a naturally occurring long linear polysaccharide known for its biocompatibility, biodegradability, and non-immunogenicity. Nanoparticles from hyaluronic acid have great potential as drug delivery carriers of chemotherapeutics and other biomolecules. The ro [....] » Read More
Title : HDAC inhibitors with non-hydroxamate warhead
Franz Josef Meyer Almes, University of Applied Sciences, Germany
Compounds with a thiazolidinedione (TZD) functionality, so called glitazones, are known as PPAR?-activators and anti-diabetic drugs. The mode of action of these glitazones has extensively be investigated and is known in great structural details. PPAR? is a prominent target with [....] » Read More
Title : The new benzamide derivatives as potential dementia drugs - synthesis, biological activity and molecular docking study
Danuta Drozdowska, Medical University of Bialystok, Poland
Designing, synthesize and developing of novel bioactive molecules is the crucial role of medicinal chemistry. The concept of drug design and development, called multi-target directed ligand (MTDL), multiple ligand strategy (MLS) or designed multiple ligands (DMLs), is an innovati [....] » Read More