The necessity of new systems for drug delivery in children is due to the difficulty of the correct dose administration when the drug carrier is not easy to administrate. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in th [....] » Read More
Novel Quantitative Structure-Activity Relationship (QSAR) models of compounds’ placenta (PL) permeability expressed as their: i) log FM (fetus-to-mother blood concentration) values; ii) Clearance Index (CI); iii) binary PL1/0 (crossing/non-crossing; Yes/No) score were gener [....] » Read More
The constant release of veterinary and human pharmaceutical drugs as active compounds or metabolites to the environment can result in the presence of undesirable contaminants in the ecosystems. Such anthropogenic contaminants can be discharged into the environment through wastewa [....] » Read More
Antibiotics are essential and versatile drugs due to the necessity of their use in cases such as surgical procedures, organ transplantations, and the treatment of cancer patients. However, due to the increasing rates of antibiotic resistance in recent years, there has been a fail [....] » Read More
The outbreak of coronavirus disease 2019 increased the use of technology, especially in the healthcare sector, which experienced enormous pressures to provide for patients’ health needs. Due to the outbreak measures such as physical distancing or self-isolation, many patien [....] » Read More
Alpha and Delta coronaviruses spread worldwide claiming >634000 lives and secondary multidrug-resistant infections were found a risk factor specifically in ICU patients containing carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecium and Kl [....] » Read More
Diabetes mellitus represents a large-scale health concern and has become a distressing hazard in the modern epoch of compromised lifestyles. So, there is an imperative need for screening and developing new pharmacologically active compounds that can meet still existing insufficie [....] » Read More
Cytokine storm has recently been recognized as the key pathology responsible for the severe symptoms of Covid-19 and other viruses and non-viral agents. The underlying biochemical cause of cytokine storms is excessive oxidative stress. Cytokine storm and its associated oxidative [....] » Read More
Exosomes are a heterogeneous group of nano-sized natural membrane vesicles released from various cells and exist in body fluids. Exosomes act as carriers with many kinds of bioactive molecules (e.g., proteins, lipids, and nucleic acids) to play an important role in cell-cell comm [....] » Read More
Objective: The fragility index is the minimum number of participants in a trial whose status has to be changed from an ‘event’ to a ‘non-event’ for a dichotomous primary outcome to turn the P-value (calculated by Fischer’s exact test) statistica [....] » Read More
Cancer remains a global public health concern due to its morbidity and mortality, and anticancer agents are crucial for the control and eradication of cancers. According to the International Agency for Research on Cancer. Although cancer chemotherapy has progressed in major strid [....] » Read More
The permeability of the liposomal membrane is an important factor in determining whether drugs encapsulated inside liposomes are released. Many studies revealed the role of thermotropic phase, saturation degree and acyl chain length for the permeability of the liposomal membrane. [....] » Read More
Wounds remain a huge public health issue, at least in terms of morbidity and long-term disability, throughout the world, especially in developing countries. Plant-derived natural products are significant as sources of medicinal agents and models for the design of new remedies. Th [....] » Read More
While AI technologies are rapidly developing in medicine, their implementation in daily care is not yet a reality and we should not be overwhelmed by the challenges we face, but instead use resources to develop AI concepts in pharmacogenomic therapies, to make them safer and more [....] » Read More
Introduction: In Present study investigated the efficacy and safety of Vildagliptin-Metformin treatment & compared to Glimepiride-Metformin treatment for type 2 diabetic patients. an essential role in glycemic control. Material & Methods: This is a prospective study of [....] » Read More
Pain is a global problem and as life expectancy increases, a greater percentage of the society suffer from muscular and joint pains. Arthralgia is regarded generally as muscular pain without inflammation. It is endemic in the society and sufferers continue to imbibe pain relievin [....] » Read More
This presentation will focus on the NLRP3 inflammasome and its involvement in the pathogenesis of cardiovascular diseases, the causes of its activation, and approaches to targeting these causes based on an extrapolation of the mechanism for preventing nitroglycerin tolerance usin [....] » Read More
Asava and Arista, two important Ayurvedic formulations, are used since more than 3000 years for the treatment of various diseases. Due to accelerated commercialization, the assurances on safety and efficacy of Ayurvedic products have become an important issue. Determination of qu [....] » Read More
Tetracyclines (TC) are a class of broad-spectrum antibiotics widely employed to treat various human and animal bacterial infections. Due to their incomplete adsorption and partial metabolization by humans and animals, more than 70% of the TC used for pharmacological treatment are [....] » Read More
Chemotherapy has remained the mainstay for the treatment of multiple types of cancers. In particular, topical use of chemotherapy has been used for skin cancers. Though effective, topical chemotherapy has been limited due to adverse effects such as local and even systemic toxicit [....] » Read More
Although the European Medicines Agency (EMA) encourages coronavirus disease 2019 (COVID-19) vaccination in pregnant women, the scientific evidence supporting the use of COVID-19 vaccines during pregnancy is still limited. Thus, we investigated adverse events following immunizatio [....] » Read More
The indigenous system of medicine in India namely Ayurveda practices Liposomal Delivery mode in Medicine. The system prepares medicated oils, Ghee preparations, and Milk for Liposomal delivery. Not only use for Liposomal delivery but also extracts fat soluble in gradients for the [....] » Read More
A headspace gas chromatography method was developed for the determination of 1-chlorobutane impurity in Prazosin Hydrochloride drug substance. Chromatographic separation of 1-chlorobutane impurity was achieved on DB-624 column (60m × 0.32 mm, 1.8 μm), consisting of 6% cy [....] » Read More
The most common disease of the entire group of myelin diseases is multiple sclerosis (MS). Experimental autoimmune encephalomyelitis (EAE) in rats is an experimental model of human multiple sclerosis. Usually the disease begins at a young age and almost inevitably leads to disabi [....] » Read More
Statement of the Problem: The risk for drug-drug interactions and related adverse side effects increases with the number of simultaneously administered drugs. Drug interactions potentiate or oppose the therapeutic of one co-administered drug. Objective: The aim of this stud [....] » Read More
Title : Nanomaterial-mediated systemically-administered m-rna-based Gene therapy directed exclusively to cancer, resulting in eradication of implanted orthotopic tumors with no side effects
A C Matin, Stanford University, United States
Chemotherapy with no or minimal side effects is an urgent need. One means of attaining it is through gene-delivered prodrug therapies (GDEPTs). Prodrugs are harmless until activated by a bacterial or viral gene product; they can kill tumors without side effects if the [....] » Read More
Title : The signification of the blood-brain barrier to the transfer of essential and toxic mineral elements
Bartolome Ribas Ozonas, Royal National Academy of Pharmacy, Spain
The blood-brain barrier protects the brain from certain ions, molecules and medicaments from their action and toxicity like the clouds in the earth's biosphere and its climate. Our thoughts induce neuron stimulation through synaptic activity, chemical reactions, electron move [....] » Read More
Title : Human nanomedicine: Emphasizing results of nanomaterials in humans
Thomas J. Webster, Hebei University of Technology, China
Nanomaterials have been widely tested in vitro and in small-order animal studies for decades. Results have shown greater tissue growth, decreased bacteria growth, and inhibited inflammation. However, few studies exist examining human tissue response to nanomaterials. This present [....] » Read More
Title : Manufacturing outlook on cell and Gene and aseptic processing according the EU GMP Annex 1
Richard Denk, SKAN AG, Switzerland
The new EU GMP Annex 1 for sterile Manufacturing was published in August 2022. The industry does now have one year's time for implementation. Exception loading and unloading for the Lyophilization which provides an implementation time of two years. What does this mean for ste [....] » Read More
Title : New excipient to formulate poorly soluble APIs
Rajendran Arunagiri, Eastman, United States
One of the toughest challenges facing the drug development today is poor solubility of the API. It is estimated that 70%+ of the APIs in drug development pipeline are poorly soluble in water. There are several approaches to this problem with many requiring processes such as spray [....] » Read More
Title : HDAC inhibitors with non-hydroxamate warhead
Franz Josef Meyer Almes, University of Applied Sciences, Germany
Compounds with a thiazolidinedione (TZD) functionality, so called glitazones, are known as PPARg-activators and anti-diabetic drugs. The mode of action of these glitazones has extensively be investigated and is known in great structural details. PPARg is a prominent target with a [....] » Read More
Title : Pharmacovigilance – Important, current trends, challenges and opportunities
Gurpreet Singh, Freyr Lifesciences Limited, United Kingdom
Pharmacovigilance is the Detection, Assessment, Understanding and Prevention of Adverse Events associates with Drugs. Over the last 2 decades there has been an increased focus on Pharmacovigilance in order to ensure Patient Safety. The Health Authority requirements for a Marketin [....] » Read More
Title : Limiting factors in implementing pharmacovigilance principles in the elderly
Hana Hassan, University of Bristol, United Kingdom
The overarching aim of pharmacovigilance is to ensure the safe and effective usage of medication across the population and optimise medicines through holistic considerations. However, within the heterogeneous elderly population, a number of unique factors are at play, limiting th [....] » Read More
Title : Intellection of molecular drug delivery models -an ayurvedic perspective
Ashtavaidyan Dr. E.T. Krishnan Mooss, Vaidyaratnam Group , India
Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several drugs have been developed and practiced from Ayurveda since ancient times to modern practice as ‘tradition to trend’. Charaka Samhita, Sushruta Samhita (~400 BC–200 [....] » Read More
Title : Factors affecting attitude of community pharmacists Towards locally manufactured pharmaceutical products in Addis ababa: A cross-sectional study
Gelila Tamyalew Eshete, Addis Ababa University, Ethiopia
Community Pharmacists (CPs) have a significant part in consumer choice in the rational use of LMPPs. The opinion of pharmacists regarding branded and generic medications can offer a perception of the potential obstacles that might have to be overcome to advance generic medicine u [....] » Read More
Title : Ciprofloxacin drug solubility in supercritical carbon dioxide and thermodynamics modelling
Gholamhossein Sodeifian, University of Kashan, Iran (Islamic Republic of)
Background: Ciprofloxacin belongs to a class of antibiotics called fluoroquinolones and is capable of acting against different types of bacterial infections pertaining to the skin, bone, and respiratory tract and those caused by typhoid [1]. Despite its potential activity against [....] » Read More
Title : Comparison of dexmedetomidine and propofol with ketofol in sedation of candidates for cataract surgery
Alireza Kamali, Arak University of Medical Sciences, Iran (Islamic Republic of)
Introduction: Cataract is the most common cause of vision loss in the world and about 30 to 40 million people in the world are scientifically blind, about 45% of which is cataract. A cataract is one of the most common surgeries performed in the elderly. The purpose of prescribing [....] » Read More
Title : Pharmacovigilance and drug safety
Aisha Rabbani , Pakistan medical and dental council, Pakistan
Pharmacovigilance is the practice of monitoring, evaluating, and preventing adverse effects or any other drug-related problems associated with the use of pharmaceutical products. Its primary goal is to promote patient safety and public health by identifying and minimizing the ris [....] » Read More
Title : N-acetyltransferase 2 genotypes are associated with type ii diabetes mallitue and triglyceride levels among a sample of jordanian patients
Yazun Bashir Jarrar, Al-Balqa Applied University, Jordan
Background: N-acetyltansferase 2 (NAT2) enzyme is a phase II drug-metabolizing enzyme that metabolizes different xenobiotic and endogenous compounds. Genetic variants in NAT2 gene affect the enzyme’s activity and hence induce certain diseases. There are controversial result [....] » Read More
Title : A QSAR survey on tyrosine kinase inhibitors
Atefeh Hajiagha Bozorgi, Alborz University of Medical Sciences, Iran (Islamic Republic of)
The epidermal growth factor receptor (EGFR) is an essential receptor tyrosine kinase (RTK) that regulates cell proliferation and differentiation and its abnormal activation contributes to a variety of human cancers. The EGFR and EGF-like peptides are often over-expressed in human [....] » Read More
Title : Fentanyl, mental health and society
Mario souza y machorro, International College of Superior Education, Mexico
The text reviews a health issue through its epidemiological scope; Points out: chemical structure, synthesis, and mechanisms of action; It discusses its potency and speed of action, forms of administration and interaction with other drugs; Instructs on medical use; It recommend [....] » Read More
Title : Genesis and functions of (PEG)-BHD1028 – A potent agonist to adiponectin receptors, AdipoR1 and AdipoR2
Brian Kim, EncuraGen, Inc., Korea, Republic of
Adiponectin, an adipokine predominantly produced by white adipocytes, has been known to play various critical roles and offer physio-regulatory benefits, including improvement in insulin sensitivity, enhancement of energy metabolism, and anti-inflammation. It has also been known [....] » Read More
Title : The new benzamide derivatives as potential dementia drugs - synthesis, biological activity and molecular docking study
Danuta Drozdowska, Medical University of Bialystok, Poland
Designing, synthesize and developing of novel bioactive molecules is the crucial role of medicinal chemistry. The concept of drug design and development, called multi-target directed ligand (MTDL), multiple ligand strategy (MLS) or designed multiple ligands (DMLs), is an innovati [....] » Read More