The necessity of new systems for drug delivery in children is due to the difficulty of the correct dose administration when the drug carrier is not easy to administrate. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in the oral cavity due to their capacity to release pharmaceutical drugs at a fast and sustained rate. Electrospun fibers have many characteristics that make them ideal drug carriers for local delivery. Mucoadhesives fibrous systems of poly (vinyl alcohol) (PVA) and poly (vinyl pyrrolidone) (PVP) loaded with propranolol and dexamethasone phosphate will be discussed for their potential application in the oral cavity. Physicochemical (SEM, FTIR, TGA, DSC) and biological (MTT assay) characterization will be described in order to present the morphology, chemical composition, and thermal behavior of the fibrous mats, and cytotoxicity in fibroblast will be visualized, drug delivery rate, mucoadhesive and degradation rate will be also discussed. The evaluated mucoadhesive loaded fibers presented potential characteristics to be used in the oral cavity, where successfully tridimensional fibrous scaffolds were fabricated with an average fiber diameter of about 368 ± 161 nm, thermal stability higher than 250oC, fibers were degraded completely before 15 min and high mucoadhesive and biocompatibility in fibroblast were observed. PVP loaded fibers with dexamethasone phosphate are proposed for endodontic procedures avoiding injection of the anti-inflammatory drug and PVA loaded fibers with propranolol for the treatment of hemangiomas in children.