Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several drugs have been developed and practiced from Ayurveda since ancient times to modern practice as ‘tradition to trend’. Charaka Samhita, Sushruta Samhita (~400 BC–200 AD) and Ashtanga Hridaya of Vagbhata are the main classics, which give detailed descriptions of over 700 herbs and 6,000 formulations. Madhav Nidan (~800 AD), a diagnostic classic, provides over 5,000 signs and symptoms of different systemic errors that may lead to mis function of bio genomics in later. Life in Ayurveda is conceived as the union of the body, senses, mind, and spirit and also involves the classification of human on the basis of their phenotype expression. Personalized medicine is the most significant outcome of modern genomic science and it has to come to develop more in the coming years. But philanthropists of Ayurveda had explained the importance of human phenotype expression (Prakriti) in maintaining health and managing the disease in a personalized manner for long years back. One of the important benefits of personalized medicine is avoiding “one size fits all” to reduce side effects differentiated with different persons. Classifying humans based on phenotype still remains a challenge to biomedical science. A number of research groups are now investigating the correlation between Ayurvedic phenotypes and individual human genotypes. A pioneering study showed significant correlation between HLA alleles and Ayurvedic phenotype (Prakriti) type (1). The biological and ethnopharmacological importance of Ayurvedic drugs are being studied with immense interest about the different chemical compounds with different types of biomechanics in the human bio environment. (2) The system of traditional Indian medicine has the wisdom of different medicinal plants to extract its biologically active phytochemicals and formulate in various dosage forms. (3) . The intellect of permutation and combination of molecules from differential herbs to nanoparticles, (Sookshma churna) liposome, (Ghee/oil based medicaments) nanoemulsion, (Avartana) ethosome,(snana churna) microsphere,(Prasa) phytosomes,(milk based kashaya) solid lipid nanoparticles (Ghrita) have contributed significantly to the enhancement of therapeutic potential and still in practise.(4) . The permutation and combination (heterogeneous phase) of extracts in the formulations have demonstrated remarkable improvement in the stability, sustained release, improved therapeutic efficacy, reduced toxicity and side effects.Thus, all the above delivery system theories are related with current scientific knowledge referring to hemodynamics, mode of nourishment, Electrolyte homeostasis, cell integrity balance, cross membrane transport, Targeted mode of activities, nutrient supply and replenishment of tissues at different levels of metabolism needs global attention for potential research for the wellness of world mankind. It was written in 950 BC by Indian philanthropist pointing ‘Loka samastha sukino Bhavanthu’ means the concept of wellness of globe which is very remarkable in the present era.