Apoptosis in colon cancer cell line through down-regulation of AKT pathway

Title : Apoptosis in colon cancer cell line through down-regulation of AKT pathway

Abstract:

Background: Cancer is a major cause of morbidity and mortality worldwide. Small heterocyclic molecules are promising anti-cancer molecules. Imidazoquinoxaline derivatives induce apoptosis in colon cancer cell line HCT-116 and Breast cancer cell line MDA-MB-231.

Aim: Investigation of Anticancer Mechanism of Imidazoquinoxaline Derivatives in Breast cancer cell and colon cancer.

Result: In MDA MB-231 breast cancer cell and HCT-116 Colon cancer cell, Imidazoquinoxaline derivatives (RA 22) down-regulate the signaling pathway such as AKT, ERK and STAT 3 & increase the cleavage of PARP, Caspase-3 and Caspase-9.

Conclusion(s): The present study demonstrated that Imidazoquinoxaline derivatives inhibited colon and breast cancer cell viability through activation of apoptosis and cell cycle arrest by increasing the cleavage of PARP, Caspase-3 & Caspase-9. Therefore, Imidazoquinoxaline derivatives can act as a therapeutic molecule for the treatment of colon cancer.

Audience Take Away Notes:

• Researchers working in this area will come to know of the potential of imidaxoquinoxaline derivatives as anticancerous agents, Studies can further be propagated using other cell lines to better understand its activity spectrum. The study outcome will be added as new information to the preexisting knowledge about various generations of anticancer agents.

Biography:

Motivating and talented Biochemistry Professor, driven to inspire students to pursue academic and personal excellence. Exceptional track record of research success with multiple published articles. Dr. Preeti Sharma is currently working at Autonomous State Medical College, Fatehpur, UP, India, deeply involved in teaching and research. Her area of research has been interdisciplinary including Drug Metabolism, Pharmacokinetics and Inflammatory Markers, Immunology. She has more than 140 publications with high citation and few in phase of communication. She also wrote 2 books, and guided and coguided many MD and Ph.D students. She is member of various professional bodies and has participated and presented number of papers in national and international conferences.  She is frequently invited as international speaker. She is awarded with many international and National Scientific Awards for exceptional contribution to research & teaching.