Abstract:
Background: Cancer is a major cause of morbidity and mortality worldwide. Small heterocyclic molecules are promising anti-cancer molecules. Imidazoquinoxaline derivatives induce apoptosis in colon cancer cell line HCT-116 and Breast cancer cell line MDA-MB-231.
Aim: Investigation of Anticancer Mechanism of Imidazoquinoxaline Derivatives in Breast cancer cell and colon cancer.
Result: In MDA MB-231 breast cancer cell and HCT-116 Colon cancer cell, Imidazoquinoxaline derivatives (RA 22) down-regulate the signaling pathway such as AKT, ERK and STAT 3 & increase the cleavage of PARP, Caspase-3 and Caspase-9.
Conclusion(s): The present study demonstrated that Imidazoquinoxaline derivatives inhibited colon and breast cancer cell viability through activation of apoptosis and cell cycle arrest by increasing the cleavage of PARP, Caspase-3 & Caspase-9. Therefore, Imidazoquinoxaline derivatives can act as a therapeutic molecule for the treatment of colon cancer.
Audience Take Away Notes:
- Researchers working in this area will come to know of the potential of imidaxoquinoxaline derivatives as anticancerous agents, Studies can further be propagated using other cell lines to better understand its activity spectrum. The study outcome will be added as new information to the preexisting knowledge about various generations of anticancer agents.
Biography:
Motivating and talented Biochemistry Professor, driven to inspire students to pursue academic and personal excellence. Consistently strive to create a challenging and engaging learning environment in which students become lifelong learners. Exceptional track record of research success with multiple published articles. Dr. Preeti Sharma is currently working in the Department of Biochemistry, Autonomous State Government Medical College, Uttar Pradesh, India, deeply involved in teaching and research. Her area of research has been interdisciplinary including Drug Metabolism, Pharmacokinetics and Inflammatory Markers, and Immunology. She has more than 135 publications (research and review articles) with high citations and few in the phase of communications. She also wrote 2 books on Bio-organic Chemistry and the Basics of Immunology. She is a member of various professional bodies and has participated and presented a number of papers in national and international conferences. She is frequently invited as an international speaker and currently, she is a global cooperative research consultant. She is credited with a number of ICMR (Indian Council of Medical Research)-STS-funded projects and has guided and co-guided a number of Ph.D. and MD students in the field of Medical Biochemistry. She is awarded the International Scientist Award in 2020 and the research excellence award in 2021, the International education award in 2021 for his exceptional contribution to research & teaching respectively. During the pandemic, she has been deeply involved in covid related research. Her contributions to covid-19 research in published in various publications and recently she was awarded the Uttar Pradesh Government DGME corona worrier award 2022.
