Title : Emerging formulation and delivery applications of Vitamin E TPGS
Abstract:
Vitamin E TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate) combines the functions of solubilizer, emulsifier, and absorption enhancer of lipophilic and poorly soluble drugs. In addition, it enhances drug bioavailability and efficacy through inhibition of the P-glycoprotein mediated drug efflux and other mechanisms which reduce first-pass metabolism and facilitate its transport, cell uptake and function. The safety and efficacy of TPGS expanded research and development in major areas. The presentation will review emerging applications of vitamin E TPGS which include:
• Multi-drug resistance and first-pass metabolism and their effect on drug efficacy, especially in cancer chemotherapy.
• Formation of prodrugs and drug conjugates and their role on drug efficacy and adverse effects.
• Synthesis of TPGS based polymers and their role in drug encapsulation, intracellular uptake, therapeutic effects, and safety.
• Excipient in nanomedicine and targeted drug delivery systems for increased therapeutic effect and reduced toxicity.
• Interactions with active pharmaceutical ingredients through antioxidant function and other mechanisms.
• Function as active pharmaceutical ingredient by selective induction of apoptosis of some cancer cells lines.
• Parenteral administration, a major component of the emerging applications of drug formulation including mRNA, peptide, and other novel drug categories.
