Speaker at Pharmaceutics and Drug Delivery Systems 2022 - Seyed Mohammad Mousavi
Tehran University of Medical Sciences, Tehran, Iran., Iran (Islamic Republic of)
Title : The effects of Anethum graveolens (dill) supplementation on lipid profile and glycemic control: A systematic review and meta-analysis of randomized controlled trials


There is an increased interest in the potential health benefits of nutraceutical therapies, such as Anethum graveolens (dill). Therefore, this systematic review and meta-analysis aimed to evaluate the effects of Anethum graveolens supplementation on lipid profiles and glycemic indices in adults. A systematic search was performed on literature published through November 2020 via PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar to find randomized controlled trials (RCTs) evaluating the effects of oral supplementation with A. graveolens on lipid profile and measures of glycemic control in adults. The random-effects model was applied to establish the weighted mean difference (WMD) and associated 95% confidence intervals (CI). Seven RCTs with a total number of 330 subjects were included in the final analysis. Pooled results indicated that A. graveolens supplementation significantly decreased low-density lipoprotein cholesterol (LDL) concentration (WMD: -15.64 mg/dL; 95% CI: -24.55 to -6.73; P=0.001), serum insulin (WMD: -2.28 μU/ml; 95% CI: -3.62 to -0.93; P=0.001), and HOMA-IR (WMD: -1.06; 95% CI: -1.91 to -0.20; P=0.01. However, there was no significant effect on serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), and fasting blood glucose (FBS). Subgroup analysis suggested that using A. graveolens in higher doses and long-term duration had beneficial effects on lipid profiles. Dose-response analysis also showed a significant reduction in FBS at doses of 1500 mg/d. The present meta-analysis indicated that Anethum graveolens could exert favorable effects on insulin resistance and serum LDL. Further research is necessary to confirm our findings.


Dr. Seyed Mohammad Mousavi earned his BSc and MSc in Nutritional Sciences from Tehran University of Medical Sciences. He is currently a Ph.D. candidate at Tehran University of Medical Sciences' Department of Community Nutrition (TUMS). Nutritional epidemiology and evidence-based nutrition are her primary research and teaching interests. Dr. Mousavi has received several awards and honors, such as being a top researcher of the Ibn Sina International Festival in Iran and ranking second in the Ph.D. entrance exam of Nutrition 2019. He has published more than 70 papers in peer-reviewed journals and has three books (650+ citations, h-index (Scopus=15, google scholar=17). He has focused on the relationship between gut microbiota and non-communicable diseases such as obesity, metabolic syndrome, type 2 diabetes, and others in recent years